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Catalog	name	Description	price
R-R-3195	Ecopipam hydrochloride CAS No.190133-94-9	Ecopipam (SCH 39166) hydrochloride/CAS No.190133-94-9 is a potent, selective and orally active antagonist of dopamine D1/D5 receptor, with Kis of 1.2 nM and 2.0 nM, respectively. Ecopipam hydrochloride shows more than 40-flod selectivity over D2, D4, 5-HT, and α2a receptor (Ki=0.98, 5.52, 0.08, and 0.73 μM, respectively). Ecopipam hydrochloride can be used for the research of schizophrenia and obesity.	price>
R-C-1496	BI-78D3 CAS:883065-90-5	BI-78D3(JNK Inhibitor X),is a potent JNK inhibitor.BI-78D3 dose-dependently inhibits the phosphorylation of JNK substrates both in vitro and in cell.BI-78D3 not only blocks JNK dependent Con A-induced liver damage but also restores insulin sensitivity in mouse models of type 2 diabetes.	price>
R-R-3196	A-582941 dihydrochloride CAS No.848591-90-2	A-582941 dihydrochloride/CAS No.848591-90-2 is a potent, selective and brain-penetrant partial agonist of α7 nAChR, with Kis of 10.8 and 16.7 nM in rat brain membranes and human frontal cortex, respectively. A-582941 dihydrochloride also binds to human 5-HT3 receptor with a Ki of 150 nM. A-582941 has the potential for cognitive deficits associated with various neurodegenerative and psychiatric disorders research.	price>
R-C-1497	SKF96365 CAS:130495-35-1	SKF96365,originally identified as a blocker of receptor-mediated calcium entry, is widely used diagnostically,as a blocker of transient receptor potential canonical type(TRPC)channels.	price>
R-R-3197	LP44 hydrochloride CAS No.824958-12-5	LP44 (hydrochloride)/CAS No.824958-12-5 is a selective 5-HT7 agonist with Ki of 0.22 nM. LP44 (hydrochloride) induces hypothermic effect in a dose-dependent manner by intracerebroventricular injection. LP44 (hydrochloride) not causes considerable hypothermic response by intraperitoneal administration.	price>
R-C-1498	AG-120(Ivosidenib) CAS:1448347-49-6	AG-120 is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1),with potential antineoplastic activity.	price>
R-R-3198	Brilaroxazine CAS No.1239729-06-6	Brilaroxazine (RP5603)/CAS No.1239729-06-6 is a potent and orally active multimodal dopamine (DA)/serotonin (5-HT) modulator. Brilaroxazine is a partial agonist of dopamine (DA) D2, D3, and D4 receptors, 5-HT1A (Ki=1.5 nM) and 5-HT2A (Ki=2.5 nM), and has antagonist activity at 5-HT2B (Ki=0.19 nM), and 5-HT7 (Ki=2.7 nM) receptors. Brilaroxazine is an atypical antipsychotic agent, and has the potential to improve cognitive impairments in neuropsychiatric and neurological diseases in vivo.	price>
R-C-1499	Nemiralisib (GSK2269557) CAS:1254036-71-9	Nemiralisib(GSK2269557 free base)is a potent and highl selective PI3Kδ inhibitor with a pKi of 9.9.	price>
R-R-3199	SB 271046 Hydrochloride CAS No.209481-24-3	SB 271046 Hydrochloride (SB 271046A)/CAS No.209481-24-3 is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 9.02, 8.55, and 8.81 for rat, pig and human, respectively. SB 271046 Hydrochloride is over 200 fold selective for the 5-HT6 receptor vs 55 other receptors, binding sites and ion channels. Anticonvulsant activity (EC50=0.16 μM).	price>
R-C-1500	gsk2292767 CAS:1254036-66-2	GSK2292767 is a potent and selective inhibitor of phosphatidylinositol 3-kinase δ(PI3Kδ;Ki=79pM).GSK2292767 is>100-fold selective for PI3Kδ over a panel of 250 kinases.	price>
R-R-3200	Talipexole dihydrochloride CAS No.36085-73-1	Talipexole dihydrochloride (B-HT 920 dihydrochloride)/CAS No.36085-73-1 is a dopamine D2 receptor agonist, α2-adrenoceptor agonist and 5-HT3 receptor antagonist, which displays antiParkinsonian activity.	price>
R-C-1501	nsc12 CAS:102586-30-1	NSC-12(NSC 172285)is an extracellular FGF trap with significant implications in cancer therapy.NSC12 inhibited the proliferation of different FGF-dependent tumour cell lines,but had no inhibitory effect on FGF-independent tumour cells expressing a constitutively active FGFR1.NSC12 was shown to inhibit FGFR phosphorylation,angiogenesis and primary and metastatic tumour growth of FGF-dependent human and mouse cancer cells.Importantly,there was no systemic toxic effect.	price>
R-R-3201	LY334370 CAS No.182563-08-2	LY334370/CAS No.182563-08-2 is a selective 5-HT1F receptor agonist with a Ki of 1.6 nM.	price>
R-C-1502	ML281 CAS:1404437-62-2	ML-281 is a potent ans selective STK33 inhibitor(IC50=14 nM).ML281 showed low nanomolar inhibition of purified recombinant STK33 and a distinct selectivity profile as compared to other STK33 inhibitors.ML281 is a valuable addition to small-molecule probes of STK33.v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog(KRAS)is the most mutated oncogene, and KRAS mutations have been found in up to 20% of all human tumors.STK33 was selectively toxic to KRAS-dependent cancer cell lines,suggesting that small-molecule inhibitors of STK33 might selectively target KRAS-dependent cancers.	price>
R-R-3202	DSP-1053 CAS No.1176326-76-3	DSP-1053/CAS No.1176326-76-3, a benzylpiperidine derivative, is a potent Serotonin Transporter (SERT) inhibitor with a Ki of 1.02 nM. DSP-1053 shows partial 5-HT1A receptor agonistic activity with a Ki of 5.05 nM. DSP-1053 has antidepressant activity.	price>
R-C-1503	CH5132799 (PA-799) CAS:1007207-67-1	CH5132799(PA-799)is a novel class I PI3K inhibitor,which exhibited a strong inhibitory activity especially against PI3Kα(IC(50)=0.014μM).In human tumor cell lines with PI3K pathway activation,CH5132799 showed potent antiproliferative activity.CH5132799 is orally available and showed significant antitumor activity in PI3K pathway-activated human cancer xenograft models in mice.CH5132799 selectively inhibited class I PI3Ks and PI3Kα mutants in in vitro kinase assays.Tumors harboring PIK3CA mutations were significantly sensitive to CH5132799 in vitro and were remarkably regressed by CH5132799 in in vivo mouse xenograft models.	price>
R-R-3203	5-HT2B antagonist-1 CAS No.393129-91-4	5-HT2B antagonist-1/CAS No.393129-91-4 is an orally active 5-HT2B receptor antagonist with an IC50 value of 33.4 nM. 5-HT2B antagonist-1 can be used in studies of diseases characterized by 5-HT2B receptor signaling, such as hepatocellular carcinoma, cardiovascular disease or gastrointestinal disease.	price>
R-C-1504	azd2932 CAS:883986-34-3	AZD-2932 is a high affinity inhibitor of VEFGR-2 and PDGFR.AZD-2932 has a balanced ~1:1 ratio of activity vs both VEGFR-2 and PDGFRβ and shows IC50 values of 8 and 4 nM against the two enzymes,respectively.It is also active on c-Kit and FLT3 with good selectivity on a panel of kinases.	price>
R-R-3204	3-Hydroxy agomelatine CAS No.166526-99-4	3-Hydroxy agomelatine/CAS No.166526-99-4 is a metabolite of Agomelatine. 3-Hydroxy agomelatine is a 5-HT2C receptor antagonist with an IC50 of 3.2 μM and a Ki of 1.8 μM.	price>
R-C-1505	xmd8-92 CAS:1234480-50-2	XMD8-92 is a potent ERK5(BMK1)/BRD4 inhibitor with Kds of 80 and 190 nM, respectively.XMD8-92 inhibits DCAMKL2,PLK4 and TNK1 with Kds of 190,600 and 890 nM,respectively.Anti-cancer activity.	price>

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