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Catalog	name	Description	price
R-C-1375	Idasanutlin (RG-7388) CAS：1229705-06-9	Idasanutlin,also known as RG7388 and RO5503781,is a highly potent and selective MDM2 antagonist with potential anticancer activity.RG7388 binds to MDM2 blocking the interaction between the MDM2 protein and the transcriptional activation domain of the tumor suppressor protein p53.By preventing the MDM2-p53 interaction,p53 is not enzymatically degraded and the transcriptional activity of p53 is restored.	price>
R-R-3075	CCG-63808 CAS No.620113-73-7	CCG-63808/CAS No.620113-73-7 is a reversible inhibitor of regulator of G-protein signaling (RGS) proteins.	price>
R-C-1376	10-deacetyl-7-xylosyl Paclitaxel CAS：90332-63-1	10-deactyl-7-xylosyl Paclitaxel is a disruptor of microtubules and derivative of paclitaxel that has been found in T.chinensis.It induces the disassembly of pig brain and Physarum microtubules in cell-free assays.10-deactyl-7-xylosyl Paclitaxel inhibits proliferation of,as well as induces cell cycle arrest at the G2/M phase and apoptosis in,PC3 prostate cancer cells.	price>
R-R-3076	GTS-21 dihydrochloride CAS No.156223-05-1	GTS-21 dihydrochloride/CAS No.156223-05-1 is a selective alpha7 nicotinic acetylcholine receptor (α7-nAChR) agonist with anti‑inflammatory and cognition‑enhancing activities. GTS-21 dihydrochloride is also a α4β2 (Ki=20 nM for humanα4β2) and 5-HT3A receptor (IC50=3.1 μM) antagonist.	price>
R-C-1377	Topotecan CAS:123948-87-8	Topotecan(SKF 104864A;NSC 609669)is a Topoisomerase I inhibitor. The IC50 values of Topotecan at 24 h are 2.73±0.25 μM of U251 cells,2.95±0.23 μM of U87 cells,5.46±0.41 μM of GSCs-U251 and 5.95±0.24 μM of GSCs-U87.	price>
R-R-3077	Olanzapine CAS No.132539-06-1	Olanzapine (LY170053)/CAS No.132539-06-1 is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptor (Ki=19 nM). Olanzapine is an atypical antipsychotic.	price>
R-C-1378	BLU-554 CAS:1707289-21-1	Fisogatinib,also known as BLU-554,is a fibroblast growth factor receptor 4 (FGFR4)inhibitor potentially for the treatment of hepatocellular carcinoma and cholangiocarcinoma.Fisogatinib demonstrates clinical benefit and tumor regression in patients with HCC with aberrant FGF19 expression.	price>
R-R-3078	S-15535 CAS No.146998-34-7	S-15535/CAS No.146998-34-7 is a highly selective 5-HT1A receptor ligand. S-15535 is an antagonist of postsynaptic 5-HT1A receptors and an agonist of presynaptic 5-HT1A receptors. S-15535 can be used in research on psychiatric disorders, such as anti-anxiety.	price>
R-C-1379	CUDC-101 CAS:1012054-59-9	CUDC-101 is a multi-targeted,small-molecule inhibitor of histone deacetylase (HDAC),epidermal growth factor receptor tyrosine kinase(EGFR/ErbB1),and human epidermal growth factor receptor 2 tyrosine kinase(HER2/neu or ErbB2)with potential antineoplastic activity.HDAC/EGFR/HER2 inhibitor CUDC-101 inhibits the activity of these three enzymes but the exact mechanism of action is presently unknown.This agent may help overcome resistance to inhibition of EGFR and Her2 through a simultaneous,synergistic inhibition of EGFR,Her2,and HDAC.	price>
R-R-3079	Clozapine CAS No.5786-21-0	Clozapine (HF 1854)/CAS No.5786-21-0 is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a Ki of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM, respectively. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM).	price>
R-C-1380	AM580 CAS:102121-60-8	AM-580 is a potent RARalpha agonist.AM580 has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells.AM580 inhibited the wnt pathway,measured by loss of nuclear beta-catenin,suggesting partial oncogene dependence of therapy.Am580 treatment increased RARbeta and lowered the level of RARgamma,an isotype whose expression we linked with tumor proliferation.	price>
R-R-3080	SB-699551 CAS No.864741-95-7	SB-699551/CAS No.864741-95-7 is a potent and selective 5-HT5A antagonist with a pKi of 8.3. SB-699551 inhibits tumorsphere formation. SB-699551 reduces phosphorylation of AKT at serine residue 473 (S473), WNK1, PRAS40. SB-699551 shows anticancer activity and has the potential for the research of breast tumor.	price>
R-C-1381	Lu AE58054 (Idalopirdine) CAS NO. 467459-31-0	Idalopirdine is a potent and selective 5-HT6 receptor antagonist for potential use in the treatment of cognitive deficits associated with Alzheimer is disease and schizophrenia.	price>
R-R-3081	Puerarin CAS No.3681-99-0	Puerarin/CAS No.3681-99-0, an isoflavone extracted from Radix puerariae, is a 5-HT2C receptor antagonist.	price>
R-C-1382	Volitinib CAS:1313725-88-0	Savolitinib,also known as Volitinib,AZD6094 or HMPL-504,is an orally bioavailable inhibitor of the c-Met receptor tyrosine kinase with potential antineoplastic activity.Volitinib selectively binds to and inhibits the activation of c-Met in an ATP-competitive manner,and disrupts c-Met signal transduction pathways.This may result in cell growth inhibition in tumors that overexpress the c-Met protein.	price>
R-R-3082	Vortioxetine CAS No.508233-74-7	Vortioxetine/CAS No.508233-74-7 is a inhibitor of 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT, with Ki values of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.	price>
R-C-1383	FMK CAS:821794-92-7	FMK is potent,highly specific and irreversible inhibitor of p90 ribosomal protein S6 kinase RSK1 and RSK2;Fmk binds in the CTKD ATP-binding site and inhibits RSK autophosphorylation at Ser386.Fmk induces significant apoptosis in human FGFR3-expressing,t(4;14)-positive multiple myeloma cells.	price>
R-R-3083	Ondansetron CAS No.99614-02-5	Ondansetron (GR 38032; SN 307)/CAS No.99614-02-5 is a highly selective 5-HT3 receptor antagonist, with IC50 value of 103 pM. Ondansetron exerts antiemetic effects by antagonizing 5-HT receptor located on local neurons in the peripheral and central nervous system. Ondansetron suppresses nausea and vomiting caused by chemotherapy and radiation therapy. Ondansetron has orally bioactivity.	price>
R-C-1384	Voreloxin CAS:175414-77-4	Voreloxin,also known as SNS-595 or Vosaroxin,is a s mall molecule and a naphthyridine analogue with antineoplastic activity.Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication. As a result,inhibition of DNA replication,RNA and protein synthesis occurs,followed by cell cycle arrest at G2 phase and induced p53-independent apoptosis.This agent shows a favorable toxicity profile in several aspects:it does not generate reactive oxygen species,as do anthracyclines,reducing the risk of cardiotoxicity.	price>
R-R-3084	Brexpiprazole CAS No.913611-97-9	Brexpiprazole (OPC-34712)/CAS No.913611-97-9, an atypical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine D2L receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM. Brexpiprazole also shows potent antagonist activity at human noradrenergic α1B (Ki=0.17 nM) and α2C receptors (Ki=0.59 nM).	price>

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