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Catalog	name	Description	price
R-C-1445	PRE-084 hydrochloride CAS:75136-54-8	AZ084 is a potent,selective,allosteric and oral active CCR8 antagonist,with a Ki of 0.9 nM.Has potential to treat asthma.	price>
R-R-3145	Alosetron Hydrochloride CAS No.122852-69-1	Alosetron Hydrochloride (GR 68755C)/CAS No.122852-69-1 is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron Hydrochloride is used for the research of irritable bowel syndrome (IBS). Alosetron blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC50 at ~55 nM. Alosetron Hydrochloride attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects.	price>
R-C-1446	GSK8573 CAS:1693766-04-9	GSK8573(compound 23)is an inactive control compound for GSK2801.GSK8573 has binding activity to BRD9 with a Kd value of 1.04 μM and is inactive against BAZ2A/B and other bromodomain familiy.	price>
R-R-3146	NAS-181 dimesylate CAS No.1217474-40-2	NAS-181 dimesylate/NAS181/CAS No.1217474-40-2 is a potent and selective antagonist of rat 5-HT1B receptor, with a Ki of 47 nM. NAS181 shows 13-fold selectivity for r5-HT1B over bovine 5-HT1B receptor (Ki=630 nM). NAS181 increases the 5-HT turnover and the synaptic concentration of 5-HT by inhibiting terminal r5-HT1B autoreceptors.	price>
R-C-1447	Torin2 CAS:1223001-51-1	Torin 2 is a potent and selective mTOR inhibitor with IC50 of 0.25 nM in p53−/−MEFs cell line;800-fold greater selectivity for mTOR than PI3K and improved pharmacokinetic properties.Inhibition of ATM/ATR/DNA-PK with EC50 of 28 nM/35 nM/118 nM,in PC3 cell lines respectively.Torin 2 decreases cell viability and induces autophagy and apoptosis.	price>
R-R-3147	Spadin TFA	Spadin TFA, a natural peptide derived from a propeptide released in blood, is a potent TREK-1 channel blocker with an IC50 value of 10 nM. Spadin TFA enhances dorsal raphe nucleus 5-HT neurotransmission in mice and induces hippocampal CREB activation and neurogenesis. Spadin TFA can be used for antidepressant research.	price>
R-C-1448	BML-210(CAY10433) CAS:537034-17-6	BML-210(CAY10433),is HDAC inhibitor.BML-210 induces growth inhibition and apoptosis and regulates HDAC and DAPC complex expression levels in cervical cancer cells.BML-210 can inhibit cell growth and induce apoptosis in cervical cancer cells,what correlates with down-regulation of HDAC class I and II and changes in the DAPC expression levels.	price>
R-R-3148	Harmine hydrochloride CAS No.343-27-1	Harmine Hydrochloride (Telepathine Hydrochloride)/CAS No.343-27-1 is a natural DYRK inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM.	price>
R-C-1449	TC-H 106 CAS:937039-45-7	TC-H 106(Pimelic Diphenylamide 106)is a slow,tight-binding inhibitor of class I histone deacetylases(HDAC)with Ki value of 148 nM,about 102 nM,14 nM for HDAC1,HDAC2,HDAC3,respectively.	price>
R-R-3149	Perospirone CAS No.150915-41-6	Perospirone (SM-9018 free base)/CAS No.150915-41-6 is an orally active antagonist of 5-HT2A receptor (Ki=0.6 nM) and dopamine D2 receptor (Ki=1.4 nM), and also a partial agonist of 5-HT1A receptor (Ki=2.9 nM). Perospirone is an atypical antipsychotic agent and has the potential for schizophrenic disease research.	price>
R-C-1450	UF 010 CAS:537672-41-6	UF-010 is a Class I HDAC inhibitor(IC50 values are 0.06,0.1,0.5 and 1.5μM for HDACs 3,2,1 and 8,respectively).UF010 inhibits cancer cell proliferation via class I HDAC inhibition.This causes global changes in protein acetylation and gene expression,resulting in activation of tumor suppressor pathways and concurrent inhibition of several oncogenic pathways.	price>
R-R-3150	AS19 CAS No.1000578-26-6	AS19/CAS No.1000578-26-6 is a potent, selective 5-HT7 receptor agonist with an IC50 value of 0.83 nM and a Ki of 0.6 nM. AS19 is selective for 5-HT7 over 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5A receptors (Kis = 89.7 nM, 490 nM, 6.6 nM and 98.5 nM, respectively). AS19 enhances memory consolidation and reverses Scopolamine- or Dizocilpine-induced amnesia.	price>
R-C-1451	KC7F2 CAS:927822-86-4	KC7F2 is an inhibitor of HIF-1αprotein translation,but not transcription,that suppresses phosphorylation of two key regulators of protein synthesis, eukaryotic translation initiation factor 4E binding protein 1(4EBP1)and p70 S6 kinase(S6K).	price>
R-R-3151	2-Methyl-5-HT CAS No.78263-90-8	2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine)/CAS No.78263-90-8 is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT is shown to display anti-depressive-like effects.	price>
R-C-1452	WDR5 0103 CAS:890190-22-4	WDR5-0103 is a small molecule that binds a peptide-binding pocket on WDR5(Kd= 450 nM),inhibiting the catalytic activity of the MLL core complex in vitro (IC50=39 µM).WD repeat domain 5(WDR5)plays an important role in various biological functions through the epigenetic regulation of gene transcription. WDR5 may have oncogenic effect and WDR5-mediated H3K4 methylation plays an important role in leukemogenesis.	price>
R-R-3152	Oxatomide CAS No.60607-34-3	Oxatomide/CAS No.60607-34-3 is a potent and orally active dual H1-histamine receptor and P2X7 receptor antagonist with antihistamine and anti-allergic activity. Oxatomide almost completely blocks the ATP-induced current in human P2X7 receptors (IC50 of 0.95 μM). Oxatomide inhibits ATP-induced Ca2+ influx with an IC50 value of 0.43 μM and also inhibits serotonin.	price>
R-C-1453	MN 64 CAS:92831-11-3	MN-64 is a potent tankyrase 1 inhibitor,with IC50s of 6 nM,72 nM,19.1μM,and 39.4μM for TNKS1,TNKS2,ARTD1 and ARTD2,respectively.	price>
R-R-3153	CP94253 hydrochloride CAS No.845861-39-4	CP94253 hydrochloride/CAS No.845861-39-4 is a potent and selective agonist of 5-HT1B receptor (Ki= 2 nM in a radioligand binding assay).Ki values for 5-HT1A, 5-HT1D, 5-HT1C and 5-HT2 receptors are 89, 49, 860, and 1600 nM respectively. CP94253 hydrochloride is centrally active upon systemic administration in vivo.	price>
R-C-1454	NCH 51 CAS:848354-66-5	PTACH(NCH-51)is a potent HDAC inhibitor with IC50s of 48 nM,32 nM,and 41 nM for HDAC1,HDAC4,and HDAC6,respectively.PTACH exerts potent growth inhibition against various cancer cells(EC50s of 1.1-9.1 µM) .	price>
R-R-3154	Setiptiline CAS No.57262-94-9	Setiptiline (Org-8282)/CAS No.57262-94-9 is a serotonin receptor antagonist. Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine.	price>

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