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Catalog	name	Description	price
R-C-1414	Pyridostain CAS:1085412-37-8	Pyridostatin(RR82)is a G-quadruplex DNA stabilizing agent(Kd=490 nM). Pyridostatin promotes growth arrest in human cancer cells by inducing replication-and transcription-dependent DNA damage.Pyridostatin targets the proto-oncogene Src.Pyridostatin reduced SRC protein levels and SRC-dependent cellular motility in human breast cancer cells.	price>
R-R-3114	Ketanserin tartrate CAS No.83846-83-7	Ketanserin (R41468) tartrate/CAS No.83846-83-7 is a selective 5-HT2 receptor antagonist. Ketanserin tartrate also blocks hERG current (IhERG) in a concentration-dependent manner (IC50=0.11 μM).	price>
R-C-1415	KPT330 CAS:1393477-72-9	KPT-330 inhibitor of CRM1(XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia.	price>
R-R-3115	Pimavanserin hemitartrate CAS No.706782-28-7	Pimavanserin (ACP-103) hemitartrate/CAS No.706782-28-7 is a potent 5-HT 2A receptor inverse agonist with pIC50 and pKi of 8.73 and 9.3, respectively.	price>
R-C-1416	Verdinexor (KPT-335) CAS: 1392136-43-4	Verdinexor（KPT-335)is an orally bioavailable Selective Inhibitor of Nuclear Export(SINE).KPT-335 inhibited proliferation,blocked colony formation,and induced apoptosis of treated cells at biologically relevant concentrations of drug.Additionally,KPT-335 downregulated XPO1 protein while inducing a concomitant increase in XPO1 messenger RNA.KPT-335 treatment of cell lines upregulated the expression of both protein and mRNA for the tumor suppressor proteins p53 and p21,and promoted their nuclear localization.	price>
R-R-3116	Prucalopride CAS No.179474-81-8	Prucalopride/CAS No.179474-81-8 is an orally active, selective and specific 5-HT 4 receptor agonist (high affinity), with pKis of 8.6 and 8.1 for human 5-HT4a/4b receptors, respectively. Prucalopride improves intestinal motility by promoting regeneration of the intestinal nervous system in rats. Prucalopride also shows anticancer activity by blocking of the PI3K/AKT/mTor signaling pathway. Prucalopride can be used in studies of chronic constipation, pseudo-intestinal obstruction and cancer.	price>
R-C-1417	KPT276 CAS:1421919-75-6	KPT-276 is an orally bioavailable inhibitor of Exportin 1(XPO1/CRM1)with anticancer activity.In vivo,KPT-276 increases survival and reduces spleen weight and white blood cell count in an MV4-11 acute myeloid leukemia(AML)mouse xenograft model.	price>
R-R-3117	8-OH-DPAT hydrobromide CAS No.76135-31-4	8-OH-DPAT (8-Hydroxy-DPAT) hydrobromide/CAS No.76135-31-4 is a potent and selective 5-HT1A agonist with a pIC50 of 8.19. 8-OH-DPAT hydrobromide has selectivity of almost 1000 fold for a subtype of the 5-HT1 binding site.	price>
R-C-1418	Siponimod (BAF312) CAS:1230487-00-9	BAF312(Siponimod)is a next-generation S1P receptor agonist,selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM,exhibits >1000-fold selectivity over S1P2,S1P3 and S1P4 receptors.	price>
R-R-3118	S1RA hydrochloride CAS No.1265917-14-3	S1RA (E-52862) hydrochloride/CAS No.1265917-14-3 is an orally active and selective sigma-1 receptor (σ1R) antagonist with a Ki value of 17 nM. S1RA hydrochloride shows good selectivity against σ2R (Ki >1000 nM). S1RA hydrochloride is a human 5-HT2B receptor antagonist with an IC50 value of 4.7 μM. S1RA hydrochloride inhibits neuropathic pain and activity-induced spinal sensitization.	price>
R-R-3119	Loxapine CAS No.1977-10-2	Loxapine/CAS No.1977-10-2 is an orally active dopamine inhibitor, 5-HT receptor antagonist and also a dibenzoxazepine anti-psychotic agent.	price>
R-C-1420	HM71224 CAS :1353552-97-2	Poseltinib,an orally active,selective and irreversible Bruton? is tyrosine kinase (BTK)inhibitor(IC50=1.95 nM),with 0.3, 2.3 and 2.4-fold selectivity for BTK over BMX,TEC and TXK,respectively.	price>
R-R-3120	Tandospirone CAS No.87760-53-0	Tandospirone (SM-3997)/CAS No.87760-53-0 is a potent and selective 5-HT1A receptor partial agonist, with a Ki of 27 nM. Tandospirone has anxiolytic and antidepressant activities. Tandospirone can be used for the research of the central nervous system disorders and the underlying mechanisms.	price>
R-C-1421	PIK293 CAS:900185-01-5	PIK-293,an analog of IC87114,is a PI3K inhibitor,with IC50 values of 0.24 μM,10μM,25μM and 100μM for p110δ,p110β,p110γ and p110α,respectively.	price>
R-R-3121	Cariprazine CAS No.839712-12-8	Cariprazine/RGH-188/CAS No.839712-12-8 is a novel antipsychotic agent candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki=2.6 nM).	price>
R-C-1422	Tipiracil HCL CAS:183204-72-0	Tipiralacil,also known as TPI,is a thymidine phosphorylase inhibitor(TPI).	price>
R-R-3122	Asenapine maleate CAS No.85650-56-2	Asenapine maleate/CAS No.85650-56-2 is a 5-HT (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) and D2 antagonist with Ki values of 0.03-4.0 nM, 1.3nM, respectively, and an antipsychotic.	price>
R-C-1423	Sertindole CAS:106516-24-9	Sertindole is one of the newer antipsychotic medications and a neuroleptic.Like the other atypical antipsychotics,it has activity at dopamine and serotonin receptors in the brain.It is used in the treatment of schizophrenia.	price>
R-R-3123	Cariprazine hydrochloride CAS No.1083076-69-0	Cariprazine hydrochloride/CAS No.1083076-69-0 is a novel antipsychotic agent candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki=2.6 nM).	price>
R-C-1424	Carbazeran CAS:70724-25-3	Carbazeran is an Aldehyde oxidase(AO)substrate and potent phosphodiesterase PDE-II and PDE-III inhibitor that produces concentration-dependent positive inotropic responses.Carbazeran shows chronotropic and inotropic effect in vivo (EC50=100μM,ionotropic effects,independent of adrenergic mechanisms).It potently inhibits cAMP hydrolysis.In humans,the compound is almost completely cleared via 4-hydroxylation to the phthalazinone metabolite by AO.	price>

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