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Catalog	name	Description	price
R-R-3010	CID44216842 CAS No.1222513-26-9	CID44216842 (Cdc42-IN-1)/CAS No.1222513-26-9 is a potent Cdc42-selective guanine nucleotide binding lead inhibitor. The EC50s for Cdc42 WT and Cdc42Q61L mutant are 1.0 and 1.2 μM in GTP binding assay, respectively. The EC50s for Cdc42 WT and Cdc42Q61L mutant are 0.3 and 0.5 μM in GDP binding assay, respectively. Use as a molecular probe.	price>
R-R-3011	MCP110 CAS No.521310-51-0	MCP110/CAS No.521310-51-0 is an inhibitor of Ras/Raf-1 interaction. MCP110 blocks the interaction of Ras with Raf. MCP110 disrupts this interaction might can be used for the research of human tumors.	price>
R-C-1311	umi-77 CAS ：518303-20-3	UMI-77 is a selective Mcl-1 inhibitor,which shows high binding affinity to Mcl-1(IC50=0.31μM).UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM,showing selectivity over other members of anti-apoptotic Bcl-2 members.	price>
R-C-1312	SQ109 CAS：502487-67-4	SQ109 is a drug undergoing development for treatment of tuberculosis.SQ109 showed activity against both drug susceptible and Multi-drug-resistant tuberculosis bacteria,including Extensively drug-resistant tuberculosis strains. In preclinical studies SQ109 enhanced the activity of anti-tubercular drugs isoniazid and rifampin and reduced by >30% the time required to cure mice of experimental TB.SQ109 is being developed by OOO Infectex in Russia and by Sequella Inc internationally.I	price>
R-R-3012	ESI-08 CAS No.301177-43-5	ESI-08/CAS No.301177-43-5 is a potent and selective EPAC antagonist, which can completely inhibit both EPAC1 and EPAC2 (IC50 of 8.4 μM) activity. ESI-08 selectively blocks cAMP-induced EPAC activation, but does not inhibit cAMP-mediated PKA activation.	price>
R-C-1313	Ilomastat (GM6001, Galardin) CAS:142880-36-2	Ilomastat,also known as GM6001 and galardin,is a broad-spectrum matrix metalloproteinase inhibitor with potential anticancer activity.GM6001 is a member of the hydroxamic acid class of reversible metallopeptidase inhibitors. The anionic state of the hydroxamic acid group forms a bidentate complex with the active site zinc.Examples of enzymes that ilomastat inhibit include thermolysin,peptide deformylase,and anthrax lethal factor endopeptidase(LF) produced by the bacterium Bacillus anthracis.	price>
R-R-3013	ASP2453 CAS No.2241719-73-1	ASP2453/CAS No.2241719-73-1 is a potent, selective and covalent KRAS G12C inhibitor. ASP2453 inhibits the Son of Sevenless (SOS)-mediated interaction between KRAS G12C and Raf with an IC50 value of 40 nM.	price>
R-C-1314	AMG337 CAS:1173699-31-4	AMG-337 is a potent and highly selective small molecule ATP-competitive MET kinase inhibitor.AMG 337 inhibits MET kinase activity with an IC50 of<5nM in enzymatic assays.	price>
R-R-3014	Y16 CAS No.429653-73-6	Y16/CAS No.429653-73-6 is a specific inhibitor of Leukemia-associated Rho guanine nucleotide exchange factor (LARG) with a Kd value of 76 nM. Y16 is active in blocking the interaction of LARG and related G-protein-coupled Rho GEFs with RhoA. Y16 shows no detectable effect on other diffuse B-cell lymphoma (Dbl) family Rho GEFs, Rho effectors, or a RhoGAP.	price>
R-C-1315	RG2833 (RGFP109) CAS:1215493-56-3	RG2833 is a brain-penetrant HDAC inhibitor with IC50s of 60 nM and 50 nM for HDAC1 and HDAC3,respectively.The Ki values for HDAC1 and HDAC3 are 32 and 5 nM, respectively.	price>
R-R-3015	K-Ras(G12C) inhibitor 12 CAS No.1469337-95-8	K-Ras(G12C) inhibitor 12/CAS No.1469337-95-8 is a K-Ras(G12C) inhibitor, the half-maximum effective concentration (EC50) for K-Ras(G12C) inhibitor 12 in H1792 cells is 0.	price>
R-C-1316	GSK0660 CAS:1014691-61-2	GSK0660 is a potent PPARβ/δ antagonist with a pIC50 of 6.8(binding assay IC50 =155 nM;antagonist assay IC50=300nM)and is nearly inactive on PPARα and PPARγ with IC50s above approximately 10 μM.GSK0660(100nM)reduces CPT1a(a PPARβ/δ target gene)expression below the basal vehicle-treated level by approximately 50%,but shows no effect on PDK4 expression,which is also a PPARβ/δ target gene in skeletal muscle cells.GSK0660(0.5μM)reduces the levels of AMPK and eNOS phosphorylation,and BMP-2,Runx-2 mRNA expression in MC3T3-E1 cells.	price>
R-R-3016	KRas G12R inhibitor 1	KRas G12R inhibitor 1 (compound 3) is a KRas G12R selective covalent inhibitor that exploits the strong nucleophilicity of mutant cysteines and binds irreversibly in the Switch II region of K-Ras. KRas G12R inhibitor 1 can be used in cancer research.	price>
R-C-1317	APD597 (JNJ-38431055) CAS:897732-93-3	APD597 is a GPR119 agonist intended for the treatment of type 2 diabetes,with EC50 of 46 nM for hGPR119.IC50 value: 46 nM(EC50)Target:hGPR119The design and synthesis of a second generation GPR119-agonist clinical candidate for the treatment of diabetes is described.APD597 was selected for preclinical development based on a good balance between agonist potency,intrinsic activity and in particular on its good solubility and reduced drug-drug interaction potential.	price>
R-R-3017	ZT-12-037-01 CAS No.2328073-61-4	ZT-12-037-01/CAS No.2328073-61-4 is a STK19-targeted inhibitor, has a high-affinity interaction with STK19 protein and inhibits oncogenic NRAS-driven melanocyte malignant transformation. ZT-12-037-01 is an ATP-competitive inhibitor, inhibiting phosphorylation of NRAS (major isoform of Ras family) with an IC50 of 24 nM.	price>
R-C-1318	CH-223191 CAS:301326-22-7	CH223191 is a potent and specific aryl hydrocarbon receptor(AhR)antagonist. CH223191 can prevent 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor.2,3,7,8-Tetrachlorodibenzo-p-dioxin(TCDD)is a widespread environmental pollutant with many toxic effects,including endocrine disruption,reproductive dysfunction,immunotoxicity,liver damage,and cancer. CH223191 potently inhibits TCDD-induced AhR-dependent transcription.In addition,CH-223191 blocked the binding of TCDD to AhR and inhibited TCDD-mediated nuclear translocation and DNA binding of AhR.These inhibitory effects of CH-223191 prevented the expression of cytochrome P450 enzymes,target genes of the AhR.CH-223191,may be a useful agent for the study of AhR-mediated signal transduction and the prevention of TCDD-associated pathology.	price>
R-R-3018	KRAS G12D inhibitor 14 CAS No.2765254-39-3	KRAS G12D inhibitor 14/CAS No.2765254-39-3 is a potent KRAS G12D inhibitor with a KD of 33 nM for binding to KRAS G12D protein. KRAS G12D inhibitor 14 decreases the active form of KRAS G12D (KRAS G12D-GTP) but not KRAS G13D.	price>
R-C-1319	Helioxanthin 8-1 CAS: 840529-13-7	Helioxanthin 8-1 is an analogue of helioxanthin,exhibites significant in vitro anti-HBV/HCV/HSV-1/HIV activity with EC50 of >5/10/1.4/15 uM.	price>
R-R-3019	XRP44X CAS No.729605-21-4	XRP44X/CAS No.729605-21-4 inhibits Ras-induced transcription activation with the IC50 of 10 nM. XRP44X inhibits activation of the Ras-Erk-1/2 pathway by FGF-2. XRP44X is an inhibitor of Ras/Erk activation of Elk3 that also affects microtubules.	price>
R-C-1320	CB5083 CAS:1542705-92-9	CB-5083 is a novel first in class,potent orally bio-available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti-tumor activity in solid and hematological models.	price>

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