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Catalog	name	Description	price
R-C-1372	ACT-678689 CAS：1783256-96-1	ACT-678689 is a potent inhibitor of tryptophan hydroxylase 1(TPH1).	price>
R-R-3072	CCG 203769 CAS No.410074-60-1	CCG 203769/CAS No.410074-60-1 is a selective G protein signaling (RGS4) inhibitor, which blocks the RGS4-Gαo protein-protein interaction in vitro with an IC50 of 17 nM.	price>
R-C-1373	GZD824 CAS：1257628-77-5	Olverembatinib,also known as GZD824,is a novel orally bioavailable inhibitor against a broad spectrum of Bcr-Abl mutants including T315I.GZD824 tightly bound to Bcr-Abl(WT)and Bcr-Abl(T315I)with K(d)values of 0.32 and 0.71 nM, respectively,and strongly inhibited the kinase functions with nanomolar IC(50) values.GZD824 potently suppressed proliferation of Bcr-Abl-positive K562 and Ku812 human CML cells with IC(50)values of 0.2 and 0.13 nM, respectively.GZD824 also displayed good oral bioavailability (48.7%),a reasonable half-life(10.6h), and promising in vivo antitumor efficacy.It induced tumor regression in mouse xenograft tumor models driven by Bcr-Abl(WT)or the mutants and significantly improved the survival of mice bearing an allograft leukemia model with Ba/F3 cells harboring Bcr-Abl(T315I).GZD824 represents a promising lead candidate for development of Bcr-Abl inhibitors to overcome acquired imatinib resistance.(J Med Chem.2013 Feb 14;56(3):879-94).	price>
R-R-3073	CCG-63802 CAS No.620112-78-9	CCG-63802/CAS No.620112-78-9 is a selective, reversible and allosteric RGS4 inhibitor. CCG-63802 specifically binds to RGS4 and blocks the RGS4-Gαo interaction, with an IC50 value of 1.9 μM.	price>
R-C-1374	E7050 CAS：928037-13-2	Golvatinib,also known as E7050,is an orally bioavailable dual kinase inhibitor of c-Me,(hepatocyte growth factor receptor)and VEGFR-2(vascular endothelial growth factor receptor-2)tyrosine kinases with potential antineoplastic activity.c-Met/VEGFR kinase inhibitor E7050 binds to and inhibits the activities of both c-Met and VEGFR-2,which may inhibit tumor cell growth and survival of tumor cells that overexpress these receptor tyrosine kinases.c-Met and VEGFR-2 are upregulated in a variety of various tumor cell types and play important roles in tumor cell growth,migration and angiogenesis.	price>
R-R-3074	BMS-192364 CAS No.202822-21-7	BMS-192364/CAS No.202822-21-7 is targeting the Gα-RGS interaction to produce an inactive Gα-RGS complex. BMS-192364 reduces urinary bladder contraction and exert RGS-agonist properties by increasing the action of GAPs on Gq proteins. BMS-192364 inhibits calcium flux.	price>
R-C-1375	Idasanutlin (RG-7388) CAS：1229705-06-9	Idasanutlin,also known as RG7388 and RO5503781,is a highly potent and selective MDM2 antagonist with potential anticancer activity.RG7388 binds to MDM2 blocking the interaction between the MDM2 protein and the transcriptional activation domain of the tumor suppressor protein p53.By preventing the MDM2-p53 interaction,p53 is not enzymatically degraded and the transcriptional activity of p53 is restored.	price>
R-R-3075	CCG-63808 CAS No.620113-73-7	CCG-63808/CAS No.620113-73-7 is a reversible inhibitor of regulator of G-protein signaling (RGS) proteins.	price>
R-C-1376	10-deacetyl-7-xylosyl Paclitaxel CAS：90332-63-1	10-deactyl-7-xylosyl Paclitaxel is a disruptor of microtubules and derivative of paclitaxel that has been found in T.chinensis.It induces the disassembly of pig brain and Physarum microtubules in cell-free assays.10-deactyl-7-xylosyl Paclitaxel inhibits proliferation of,as well as induces cell cycle arrest at the G2/M phase and apoptosis in,PC3 prostate cancer cells.	price>
R-R-3076	GTS-21 dihydrochloride CAS No.156223-05-1	GTS-21 dihydrochloride/CAS No.156223-05-1 is a selective alpha7 nicotinic acetylcholine receptor (α7-nAChR) agonist with anti‑inflammatory and cognition‑enhancing activities. GTS-21 dihydrochloride is also a α4β2 (Ki=20 nM for humanα4β2) and 5-HT3A receptor (IC50=3.1 μM) antagonist.	price>
R-C-1377	Topotecan CAS:123948-87-8	Topotecan(SKF 104864A;NSC 609669)is a Topoisomerase I inhibitor. The IC50 values of Topotecan at 24 h are 2.73±0.25 μM of U251 cells,2.95±0.23 μM of U87 cells,5.46±0.41 μM of GSCs-U251 and 5.95±0.24 μM of GSCs-U87.	price>
R-R-3077	Olanzapine CAS No.132539-06-1	Olanzapine (LY170053)/CAS No.132539-06-1 is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptor (Ki=19 nM). Olanzapine is an atypical antipsychotic.	price>
R-C-1378	BLU-554 CAS:1707289-21-1	Fisogatinib,also known as BLU-554,is a fibroblast growth factor receptor 4 (FGFR4)inhibitor potentially for the treatment of hepatocellular carcinoma and cholangiocarcinoma.Fisogatinib demonstrates clinical benefit and tumor regression in patients with HCC with aberrant FGF19 expression.	price>
R-R-3078	S-15535 CAS No.146998-34-7	S-15535/CAS No.146998-34-7 is a highly selective 5-HT1A receptor ligand. S-15535 is an antagonist of postsynaptic 5-HT1A receptors and an agonist of presynaptic 5-HT1A receptors. S-15535 can be used in research on psychiatric disorders, such as anti-anxiety.	price>
R-C-1379	CUDC-101 CAS:1012054-59-9	CUDC-101 is a multi-targeted,small-molecule inhibitor of histone deacetylase (HDAC),epidermal growth factor receptor tyrosine kinase(EGFR/ErbB1),and human epidermal growth factor receptor 2 tyrosine kinase(HER2/neu or ErbB2)with potential antineoplastic activity.HDAC/EGFR/HER2 inhibitor CUDC-101 inhibits the activity of these three enzymes but the exact mechanism of action is presently unknown.This agent may help overcome resistance to inhibition of EGFR and Her2 through a simultaneous,synergistic inhibition of EGFR,Her2,and HDAC.	price>
R-R-3079	Clozapine CAS No.5786-21-0	Clozapine (HF 1854)/CAS No.5786-21-0 is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a Ki of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM, respectively. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM).	price>
R-C-1380	AM580 CAS:102121-60-8	AM-580 is a potent RARalpha agonist.AM580 has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells.AM580 inhibited the wnt pathway,measured by loss of nuclear beta-catenin,suggesting partial oncogene dependence of therapy.Am580 treatment increased RARbeta and lowered the level of RARgamma,an isotype whose expression we linked with tumor proliferation.	price>
R-R-3080	SB-699551 CAS No.864741-95-7	SB-699551/CAS No.864741-95-7 is a potent and selective 5-HT5A antagonist with a pKi of 8.3. SB-699551 inhibits tumorsphere formation. SB-699551 reduces phosphorylation of AKT at serine residue 473 (S473), WNK1, PRAS40. SB-699551 shows anticancer activity and has the potential for the research of breast tumor.	price>
R-C-1381	Lu AE58054 (Idalopirdine) CAS NO. 467459-31-0	Idalopirdine is a potent and selective 5-HT6 receptor antagonist for potential use in the treatment of cognitive deficits associated with Alzheimer is disease and schizophrenia.	price>
R-R-3081	Puerarin CAS No.3681-99-0	Puerarin/CAS No.3681-99-0, an isoflavone extracted from Radix puerariae, is a 5-HT2C receptor antagonist.	price>

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