Xi'an ruixi Biological Technology Co

Home > Keywords >

Catalog	name	Description	price
R-R-2850	Survodutide TFA	Survodutide (BI 456906) TFA is a potent, selective glucagon receptor/GLP-1 receptor (GCGR/GLP-1R) dual agonist with EC50s of 0.52 nM and 0.33 nM in CHO-K1 cells, respectively. Survodutide TFA, a 29-amino-acid peptide, is a potent acylated peptide containing a C18 fatty acid. Survodutide TFA has robust anti-obesity efficacy achieved by increasing energy expenditure and decreasing food intake.	price>
R-C-1151	Tafluprost CAS:209860-87-7	Tafluprost,also known as MK2452 and AFP-168,is a prostaglandin analogue used topically(as eye drops)to control the progression of glaucoma and in the management of ocular hypertension.It reduces intraocular pressure by increasing the outflow of aqueous fluid from the eyes.	price>
R-R-2851	Glucagon-like peptide 1 (1-37), human TFA	Glucagon-like peptide 1 (1-37), human (TFA) is a highly potent agonist of the GLP-1 receptor.	price>
R-C-1152	SNG-1153 CAS：1446712-19-1	SNG-1153 is a modulator of estrogen receptor ER-alpha36.	price>
R-R-2852	Crotedumab CAS No.1452387-69-7	Crotedumab (REGN1193)/CAS No.1452387-69-7 is a fully human IgG4 monoclonal antibody that binds and inhibits glucagon receptor (GCGR), with a KD of 0.1 nM. Crotedumab can be used for the research of diabetes.	price>
R-C-1153	SU6656 cas:330161-87-0	SU6656 is a potent and selective dual inhibitor of Src family kinases and Aurora kinase.SU6656 modulates CTGF(connective tissue growth factor)expression in an ERK-dependent manner.SU6656 induces caspase-independent cell death in FRO anaplastic thyroid carcinoma cells and therapeutic synergy in human synovial sarcoma growth,invasion and angiogenesis in vivo.	price>
R-R-2853	VU0453379 CAS No.1638646-27-1	VU0453379/CAS No.1638646-27-1 is a highly selective and central nervous system (CNS) penetrant positive allosteric modulator (PAM) of glucagon-like peptide-1R (GLP-1R) with an EC50 of 1.3 μM.	price>
R-C-1154	BS-181 CAS:1397219-81-6	BS-181 is a highly selective CDK inhibitor for CDK7 with an IC(50)of 21 nmol/L. Testing of other CDKs as well as another 69 kinases showed that BS-181 only inhibited CDK2 at concentrations lower than 1 micromol/L,with CDK2 being inhibited 35-fold less potently(IC(50) 880 nmol/L)than CDK7.In MCF-7 cells,BS-181 inhibited the phosphorylation of CDK7 substrates,promoted cell cycle arrest and apoptosis to inhibit the growth of cancer cell lines,and showed antitumor effects in vivo.	price>
R-R-2854	GLP-1R agonist 4 CAS No.2401894-26-4	GLP-1R agonist 4/CAS No.2401894-26-4 is a potent agonist of GLP-1R. Glucagon-like peptide-1 (GLP-1) is an intestinal hypoglycemic hormone secreted by L-cells in the lower gastrointestinal tract. GLP-1R agonist 4 has the potential for the research of diabetes (extracted from patent WO2019239319A1, compound 96).	price>
R-C-1155	PLX647 CAS: 873786-09-5	20pecific dual FMS and KIT kinase inhibitor,with IC50s of 28 and 16 nM, respectively.PLX647 shows selectivity for FMS and KIT over a panel of 400 kinases at a concentration of 1 μM except FLT3 and KDR(IC50s=91 and 130 nM, respectively).	price>
R-R-2855	Exendin (5-39) CAS No.196109-27-0	Exendin (5-39)/CAS No.196109-27-0 is a potent glucagon-like peptide 1 (GLP-1) receptor antagonist. Exendin (5-39) improves memory impairment in β-amyloid protein-treated rats.	price>
R-C-1156	L-701,324 CAS:142326-59-8	L-701,324 is a potent and selective NMDA/glycine receptor antagonist.L-701,324 exhibits a beneficial action in the animal model of parkinsonian rigidity.Pre-treatment with L-701,324 improves pharmacosensitivity in a mouse kindling model.	price>
R-R-2856	HAEGTFTSD CAS No.926018-45-3	HAEGTFTSD/CAS No.926018-45-3 is a 9-residue peptide of human GLP-1 peptide or GLP-1(7-36), amide (HY-P0054A). GLP-1(7-36), amide is a physiological incretin hormone that stimulates insulin secretionin a glucose-dependant manner.	price>
R-C-1157	CIQ CAS:486427-17-2	CIQ is a GluN2C/GluN2D subunit-selective NMDA receptor potentiator,which reverses MK-801-induced impairment in prepulse inhibition and working memory in Y-maze test in mice.The facilitation of GluN2C/GluN2D-containing receptors may serve as an important therapeutic strategy for treating positive and cognitive symptoms in schizophrenia.	price>
R-R-2857	HAEGTFTSDVS CAS No.864915-61-7	HAEGTFTSDVS/CAS No.864915-61-7 is the first N-terminal 1-11 residues of GLP-1 peptide.	price>
R-C-1158	Pexidartinib (PLX-3397) CAS:1029044-16-3	Pexidartinib(PLX-3397)is a potent, orally active,selective, and ATP-competitive colony stimulating factor 1 receptor(CSF1R or M-CSFR)and c-Kit inhibitor,with IC50s of 20 and 10 nM respectively.Pexidartinib(PLX-3397) exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases.Pexidartinib(PLX-3397)induces cell apoptosis and has anti-tumor activity.	price>
R-R-2858	GLP-1R agonist 3 CAS No.2428640-18-8	GLP-1R agonist 3/CAS No.2428640-18-8 is a potent agonist of GLP-1R. GLP-1R agonist 3 is a thickened imidazole derivative compound. Glucagon-like peptide-1 (GLP-1) is an intestinal hypoglycemic hormone secreted by L-cells in the lower gastrointestinal tract. GLP-1R agonist 3 has the potential for the research of diabetes (extracted from patent WO2021197464A1, compound 1).	price>
R-C-1159	omarigliptin CAS:1226781-44-7	Omarigliptin(MK-3102)is a competitive,reversible inhibitor of DPP-4(IC50=1.6 nM,Ki=0.8nM).It is highly selective over all proteases tested (IC50>67 μM), including QPP,FAP,PEP,DPP8,and DPP9 and has weak ion channel activity (IC50>30 μM at IKr,Caγ1.2,and Naγ1.5).	price>
R-R-2859	Glucagon receptor antagonists-1 CAS No.503559-84-0	Glucagon receptor antagonists-1/CAS No.503559-84-0 is a highly potent glucagon receptor antagonist.	price>
R-C-1160	Anacetrapib (MK-0859) CAS:875446-37-0	Anacetrapib,also known as MK-0859,is a CETP inhibitor being developed to treat hypercholesterolemia(elevated cholesterol levels)and prevent cardiovascular disease.	price>

498499500501502503 504505506507508