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Catalog	name	Description	price
R-R-2664	(S)-MCPG CAS No.150145-89-4	(S)-MCPG ((+)-MCPG)/CAS No.150145-89-4 is a potent group I/II metabotropic glutamate receptor (mGluRs) antagonist and the active isomer of (RS)-MCPG (HY-100371). (S)-MCPG can be used for the study of the function of mGluRs in spatial learning.	price>
R-C-965	Polyamindoamine G5-polyethylene glycol-Vancomycin	Polyamide amine dendrimer(PAMAM)is a kind of highly branched and symmetrical nano scale polymer compound.The cavity inside the molecule can be used to encapsulate drug molecules,and the terminal group can be modified to connect ligands,antibodies and other bioactive substances.The high density positive charge of the molecule can compress DNA.The molecular weight of 2K and 5K MPEG SC was used to bind G5 PAMAM was modified with two kinds of amino groups.The number of PEG with low degree of substitution was 13,and that with high degree of substitution was 51,which was 10% and 40% of the amino groups on the surface of g5pamam,respectively.Vancomycin(Van)is a kind of glycopeptide antibiotics. Its binding ability with target bacteria is equal to that of antigen antibody. It has the advantages of good stability,easy preparation and preservation.	price>
R-R-2665	MMPIP hydrochloride CAS No.1215566-78-1	MMPIP hydrochloride/CAS No.1215566-78-1 is an allosteric metabotropic glutamate receptor 7 (mGluR7) selective antagonist (KB values 24 -30 nM). MMPIP hydrochloride acts as a pharmacological tool for elucidating the roles of mGluR7 on central nervous system functions. MMPIP hydrochloride alleviates pain and normalizes affective and cognitive behavior in neuropathic mice.	price>
R-C-966	MS275-CY5.5	MS-275 is a histone deacetylase inhibitor that has shown potent and unique anticancer activity in preclinical models.The aims of this phase I trial were to determine the dose-limiting toxicities and maximum tolerated dose of oral MS-275 in humans administered with food on a once weekly schedule and to study the pharmacokinetics of oral MS-275.	price>
R-R-2666	Mavoglurant CAS No.543906-09-8	Mavoglurant (AFQ056)/CAS No.543906-09-8 is a potent, selective, non-competitive and orally active mGluR5 antagonist, with an IC50 of 30 nM. Mavoglurant shows a >300 fold selectivity for the mGluR5 over all targets (238) tested. Mavoglurant is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-C-967	BocNH2-TK-NH2	Palladium catalyzed Buchwald Hartwig amination with BocNH2 as amine source and palladium catalyzed Hiyama coupling reaction of 2-trimethylsilylpyridine with brominated aromatic hydrocarbons.Palladium catalyzed Buchwald Hartwig amination with bocnh2 as amine source.The effects of catalyst,ligand,base,solvent and temperature on the reaction were investigated.	price>
R-R-2667	Dipraglurant CAS No.872363-17-2	Dipraglurant (ADX48621)/CAS No.872363-17-2 is a potent, selective, orally active and brain penetrant mGluR5 negative allosteric modulator (NAM), with an IC50 of 21 nM. Dipraglurant can reduce Levodopa-induced dyskinesia (LID) in vivo. Dipraglurant is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-C-968	25 hydroxyvitamin D-nhs	25 hydroxyvitamin D(25 hydroxyvitamin d)is a kind of sterol hormone,which plays an important role in promoting the absorption of calcium in the intestine and maintaining its dynamic balance.It plays a key role in the growth and health of human bones.Vitamin D not only has skeletal effects,but also has non skeletal effects related to autoimmune diseases,diabetes,cardiovascular diseases,cell growth and differentiation.Vitamin D3 can be synthesized from skin tissue exposed to ultraviolet light.	price>
R-R-2668	L-Glutamine-15N-1 CAS No.59681-32-2	L-Glutamine-15N-1/CAS No.59681-32-2 is the 15N-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells.	price>
R-C-969	N-nervonoyl-D-erythro-sphingosylphosphorylcholine, powder	Ceramide is a family of waxy lipid molecules.Ceramide is composed of a sphingosine molecule and a fatty acid molecule.Ceramide has a high concentration in the cell membrane of eukaryotic cells,because it is the main component of phospholipid bilayer-sphingomyelin.Phosphorylcholine is an amphoteric molecule composed of a hydrophilic head and a hydrophobic tail.Also known as lecithin. Phosphatidylcholine is one of the main components of phospholipids,which is extracted from plants.	price>
R-R-2669	RO0711401 CAS No.714971-87-6	RO0711401/CAS No.714971-87-6 is a selective and orally active positive allosteric modulator of mGlu1 receptor with an EC50 of 56 nM.	price>
R-C-970	Oil soluble nano iron star (particle size below 50nm)	Nano iron is the iron formed by the superposition of iron atoms one by one according to the nanometer level(e-9m).There is no difference in physical properties,but the difference is in chemical properties.For example,ordinary iron will not easily burn,but nano iron can spontaneously ignite in the air; ordinary iron has weak corrosion resistance,while nano iron has corrosion resistance.	price>
R-R-2670	Foliglurax monohydrochloride	Foliglurax monohydrochloride (PXT002331 monohydrochloride) is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) , with an EC50 of 79 nM. Antiparkinsonian effect.	price>
R-C-971	0prozomib(ONX0912) cas:935888-69-0	Oprozomib(onx 0912;pr047)is an oral biocompatible inhibitor, which can inhibit the ct-l activity of 20S proteasome (20S proteasome)β 5/LMP7 with IC50 of 36 nm /82 nm.	price>
R-R-2671	Basimglurant CAS No.802906-73-6	Basimglurant (RG7090)/CAS No.802906-73-6 is a potent, selective and orally available mGlu5 negative allosteric modulator with a Kd of 1.1 nM. Basimglurant is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-C-972	MS-275 cas:209783-80-2	MS-275 is an inhibitor of HDAC (histone deacetylase) that preferentially inhibits HDAC1(IC50=300 nM)over HDAC3(IC50=8 μM).However,MS-275 does not inhibit HDAC8 (IC50>100μM).MS-275 induces cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1),slowing cell growth,differentiation,and tumor development in vivo.Recent studies suggest that MS-275 may be particularly useful as an antineoplastic agent when combined with other drugs,like adriamycin,inhibitors of poly(ADP-ribose)polymerase(PARP),or inhibitors of heat shock protein 90 (Hsp90).	price>
R-R-2672	MSOP CAS No.66515-29-5	MSOP/CAS No.66515-29-5 is a selective group III metabotropic glutamate receptor antagonist with apparent KD of 51 μM for the L-AP4-sensitive presynaptic mGluR.	price>
R-R-2673	MPEP CAS No.96206-92-7	MPEP/CAS No.96206-92-7 is a potent, selective, noncompetitive, orally active and systemically active mGlu5 receptor antagonist, with an IC50 of 36 nM for completely inhibiting quisqualate-stimulated phosphoinositide (PI) hydrolysis. MPEP has anxiolytic-or antidepressant-like effects. MPEP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-C-974	Obatoclax mesylate cas:803712-79-0	Obatoclax Mesylate is the mesylate salt of obatoclax,a synthetic small-molecule inhibitor of the bcl-2 family of proteins with potential pro-apoptotic and antineoplastic activities.Obatoclax binds to members of the Bcl-2 protein family,preventing the binding of these anti-apoptotic proteins to the pro-apoptotic proteins Bax and Bak and so promoting the activation of the apoptotic pathway in Bcl-2-overexpressing cells.The Bcl-2 family of proteins(bcl-2,bcl-xl, bcl-w,and Mcl-1)are overexpressed in a wide variety of cancers,including those of the lymphatic system,breast,lung,prostate,and colon.	price>
R-R-2674	VU0650786 CAS No.1809085-30-0	VU0650786/CAS No.1809085-30-0 is a potent and selective CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM), with an IC50 of 392 nM. VU0650786 has antidepressant and anxiolytic activity in rodents.	price>

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