XPA Peptide

Xeroderma pigmentosum group A-complementing protein (XPA) is involved in DNA excision repair by binding to damaged sites with various affinities depending on photoadduct and transcriptional state. Defects in XPA are a cause of xeroderma pigmentosum complementation group A characterized by solar sensitivity and skin cancer predisposition.XPA is a zinc finger protein, which plays a central role in nucleotide excision repair (NER). XPA interacts with DNA and several NER proteins, acting as a scaffold to assemble the NER incision complex at sites of DNA damage. Mutations in XPA cause Xeroderma pigmentosum complementation group A (XP-A), an autosomal recessive skin disorder featuring hypersensitivity to sunlight and increased risk for skin cancer.

MSDS of XPA Peptide