(S,R,S)-AHPC-Me hydrochloride
(S,R,S)-AHPC-Me hydrochloride
Product description
(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me hydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM.
| Appearance | N/A |
|---|---|
| Molecular Weight | 481.05 |
| Purity | >90% |
| CAS | 1948273-03-7 |
| Formula | C23H33ClN4O3S |
| Storage | -20℃, protected from light and moisture |
| Transportation | 4-25℃ temperature for up to 2 weeks |
| Stability | 1 year |
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