Polyamindoamine G5-polyethylene glycol-Vancomycin

Polyamide amine dendrimer(PAMAM)is a kind of highly branched and symmetrical nano scale polymer compound.The cavity inside the molecule can be used to encapsulate drug molecules,and the terminal group can be modified to connect ligands,antibodies and other bioactive substances.The high density positive charge of the molecule can compress DNA.The molecular weight of 2K and 5K MPEG SC was used to bind G5 PAMAM was modified with two kinds of amino groups.The number of PEG with low degree of substitution was 13,and that with high degree of substitution was 51,which was 10% and 40% of the amino groups on the surface of g5pamam,respectively.Vancomycin(Van)is a kind of glycopeptide antibiotics. Its binding ability with target bacteria is equal to that of antigen antibody. It has the advantages of good stability,easy preparation and preservation.

msds---Polyamindoamine G5-polyethylene glycol-Vancomycin