PEG-PAE（200nm）

PAEs poly(β-amino esters) is a kind of hydrophobic polymer,which is often combined with PEG as a amphiphilic copolymer.Peg-b-pae is used to prepare pH responsive micelles.When PAE is in acidic environment,it becomes soluble by protonation of amino groups in the structure.Based on the characteristic of charge transition under acidic condition of PAE,the acidic environment of tumor is used as a signal to trigger PAE to release the encapsulated drug.The main feature of MPEG PAEs is that we can start from the synthetic monomer of PAEs and change its structure,so that the amphiphilic copolymer of MPEG PAEs can destroy its structure and release drugs at different pH values.The pH response range is 5-8,that is,the micelle of MPEG PAEs can respond to ph5-5.3,ph5-5.5,ph6.5-6.8 and weak base 5-8 response.We can also modify various active groups or target molecules,such as folic acid,at the end of PEG.

msds---PEG-PAE（200nm）