PD173955 CAS:260415-63-2

PD-173955 is a src tyrosine kinase inhibitor.PD173955 inhibited Bcr-Abl-dependent cell growth.PD173955 has an IC(50)of 1-2 nM in kinase inhibition assays of Bcr-Abl,and in cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation.PD173955 inhibited kit ligand-dependent c-kit autophosphorylation(IC(50)=approximately 25nM)and kit ligand-dependent proliferation of M07e cells(IC(50)=40nM)but had a lesser effect on interleukin 3-dependent(IC(50)=250nM)or granulocyte macrophage colony-stimulating factor (IC(50)=1 microM)-dependent cell growth.

,msds---PD173955