nsc12 CAS:102586-30-1

NSC-12(NSC 172285)is an extracellular FGF trap with significant implications in cancer therapy.NSC12 inhibited the proliferation of different FGF-dependent tumour cell lines,but had no inhibitory effect on FGF-independent tumour cells expressing a constitutively active FGFR1.NSC12 was shown to inhibit FGFR phosphorylation,angiogenesis and primary and metastatic tumour growth of FGF-dependent human and mouse cancer cells.Importantly,there was no systemic toxic effect.

msds---nsc12