NG25 CAS:1315355-93-1

NG-25 is a type II kinase inhibitor that inhibits MAP4K2 and TAK1.It also inhibits the Src family kinases Src and LYN and Abl family kinases as well as CSK,FER,and p38.NG 25 prevents TNF-α-induced IKKα/β phosphorylation and IκB-α degradation in L929 cells.It inhibits secretion of IFN-α and IFN-β induced by CpG type B and CL097,respectively.NG 25 decreases cell viability of HCT116KRASWT,and to a greater degree of HCT116KRASG13D, colorectal cancer cells in a concentration-dependent manner.It also reduces tumor growth and increases the number of TUNEL-positive tumor cells in a CT26KRASG12D mouse orthotopic model of colorectal cancer.

msds---NG25