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MMRi62 CAS No.352693-80-2

Catalog #	Pkg Size	Price(USD)	Quantity	Buy this product
R-R-2122	25mg	280.00	- +	+ Add to cart
R-R-2122	50mg	460.00	- +	+ Add to cart

Product description

MMRi62/CAS No.352693-80-2, a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53). MMRi62 shows a P53-independent pro-apoptotic activity against pancreatic ductal adenocarcinoma (PDAC) cells and induce autophagy. MMRi62 inducesferroptosis, resulting in a increase of reactive oxygen and lysosomal degradation of ferritin heavy chain (FTH1). MMRi62 also leads to proteasomal degradation of mutant p53, also inhibits orthotopic xenograft PDAC mouse model in vivo with high frequency mutation characteristics of KRAS and TP53.12.

Appearance	N/A
Molecular Weight	396.27
Purity	>90%
CAS	352693-80-2
Formula	C21H15Cl2N3O
Storage	-20℃, protected from light and moisture
Transportation	4-25℃ temperature for up to 2 weeks
Stability	1 year

Document

msds of MMRi62 CAS No.352693-80-2