Lacidipine CAS:103890-78-4

Lacidipine is a dihydropyridine L-type calcium channel blocker.It induces relaxation of isolated rat aorta and inhibits calcium-induced contraction of rabbit ear artery.It also induces relaxation of calcium-induced contractions in isolated rat colon and bladder and guinea pig trachea. Lacidipine induces negative inotropy in isolated guinea pig ventricular strips.It reduces mean blood pressure in spontaneously hypertensive rats and in renal hypertensive dogs with a transient increase in heart rate.Lacidipine inhibits copper-induced oxidation of isolated human LDL when used at concentrations of 1 and 5µM.It reduces the extension of aortic atheromatous lesions and decreases renal injury in ApoE-/-mice in a model of Western diet-induced atherosclerosis.

msds---Lacidipine