JNK Inhibitor IX CAS：312917-14-9

JNK Inhibitor IX is a thienylnaphthamide compound that is a selective and potent inhibitor of the ATP binding site of JNK2 and JNK3.JNK1,p38α and other kinases are effected slightly or not at all when JNK2 and JNK3 are inhibited by the JNK inhibitor IX.In comparison to SP600125(sc-200635),the inhibitor of JNK,JNK inhibitor IX is more selective between JNK1 and JNK3.The JNK pathway plays important roles in various cellular processes and is activated when cells are exposed to proinflammatory cytokines, environmental stress and different anticancer drugs.Research shows that JNK1,JNK2,and JNK3 are associated in P-glycoprotein-mediated multidrug resistance of hepatocellular carcinoma cells.

msds---JNK Inhibitor IX