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Gliotoxin CAS No.67-99-2

Catalog #	Pkg Size	Price(USD)	Quantity	Buy this product
R-R-1236	5mg	410.00	- +	+ Add to cart
R-R-1236	10mg	680.00	- +	+ Add to cart

Product description

Gliotoxin/CAS No.67-99-2 is a secondary metabolite, the most abundant mycotoxin secreted by A. fumigatus, inhibits the phagocytosis of macrophages and the immune functions of other immune cells . Gliotoxin inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces host-cell apoptosis. Gliotoxin activates PKA and increases intracellular cAMP concentration; modulates actin cytoskeleton rearrangement to facilitate A. fumigatus internalization into lung epithelial cells. Gliotoxin is a potent NOTCH2 transactivation inhibitor, can effectively induce apoptosis of chronic lymphocytic leukemia (CLL) cells.

Appearance	N/A
Molecular Weight	326.39
Purity	>90%
CAS	67-99-2
Formula	C13H14N2O4S2
Storage	-20℃, protected from light and moisture
Transportation	4-25℃ temperature for up to 2 weeks
Stability	1 year

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