FG4592 CAS No. 808118-40-3

The hypoxia-inducible factor(HIF)pathway alters gene expression in response to low oxygen tension.Under normoxic conditions,HIF-specific prolyl hydroxylases (HIF-PHs)initiate the degradation of oxygen-sensitive HIF isoforms.As 2-oxoglutarate(2-OG)is a required co-factor for HIF-PH activity,analogs of 2-OG may inhibit HIF-PH and prevent HIF turnover.1 FG-4592 is an analog of 2-OG that has been developed as an inhibitor of HIF-PHs.While little has been published regarding the actions of this compound,similar HIF-PH inhibitors suppress HIF degradation and in this way induce erythropoietin expression,promoting erythropoiesis or preventing anemia in vivo.

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