Disulfide modified paclitaxel

Disulfide bond is a chemical bond that connects the sulfhydryl groups of two different cysteine residues in different peptide chains or the same peptide chain.Disulfide bond is a relatively stable covalent bond,which plays a role in stabilizing the spatial structure of peptide chain in protein molecules. Paclitaxel can make tubulin and tubulin dimer of microtubule lose dynamic balance,induce and promote tubulin polymerization,microtubule assembly,prevent depolymerization,so as to stabilize microtubule,inhibit the mitosis of cancer cells and trigger apoptosis,and then effectively prevent the proliferation of cancer cells and play an anti-cancer role.

msds----modified paclitaxel