CP945598.HCl CAS：686347-12-6

CP 945598 hydrochloride(Otenabant HCl)is a potent and selective cannabinoid type 1 receptor antagonist that inhibits both basal and cannabinoid agonist-mediated CB(1)receptor signaling in vitro and in vivo.It displays low affinity for human CB2 receptors with Ki of 7600 nM. In vivo,CP-945598 reversed cannabinoid agonist-mediated responses,reduced food intake,and increased energy expenditure and fat oxidation in rodents.CP 945598 exhibits dose and concentration-dependent anorectic activity in two models of acute food intake in rodents,fast-induced re-feeding and spontaneous,nocturnal feeding.CP-945598 also acutely stimulates energy expenditure in rats and decreases the respiratory quotient indicating a metabolic switch to increased fat oxidation.

msds---CP945598.HCl