CH-223191 CAS:301326-22-7

CH223191 is a potent and specific aryl hydrocarbon receptor(AhR)antagonist. CH223191 can prevent 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor.2,3,7,8-Tetrachlorodibenzo-p-dioxin(TCDD)is a widespread environmental pollutant with many toxic effects,including endocrine disruption,reproductive dysfunction,immunotoxicity,liver damage,and cancer. CH223191 potently inhibits TCDD-induced AhR-dependent transcription.In addition,CH-223191 blocked the binding of TCDD to AhR and inhibited TCDD-mediated nuclear translocation and DNA binding of AhR.These inhibitory effects of CH-223191 prevented the expression of cytochrome P450 enzymes,target genes of the AhR.CH-223191,may be a useful agent for the study of AhR-mediated signal transduction and the prevention of TCDD-associated pathology.

msds---CH-223191