BOLD-100 free base CAS No.783324-98-1

BOLD-100 (NKP-1339; IT-139) free base/CAS No.783324-98-1 is a ruthenium-based anticancer agent. BOLD-100 free base also is an inhibitor of stress-induced GRP78 upregulation, disrupting endoplasmic reticulum (ER) homeostasis and inducing ER stress and unfolded protein response (UPR). BOLD-100 free base interferes with the complex interplay between ER-stress response, lysosome dynamics, and autophagy execution.The free form of the compound is prone to instability, it is advisable to consider the stable salt form (BOLD-100) that retains the same biological activity.

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