AZ1495,cas:2196204-23-4

AZ1495(C21H31N5O2,385.51), a weak base, is a potent orally active interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor. AZ1495 has a favorable physicochemical and kinase selectivity for IRAK4 and IRAK1 with IC50 values of 0.005μM and 0.023 μM, respectively. AZ1495 has IRAK4 inhibition with a Kd value of 0.0007μM. AZ1495 can be used for the research of diffuse large B-cell lymphoma (DLBCL).

msds of N-(4-morpholin-4-ylcyclohexyl)-5-(oxan-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine