Arry-520 (Filanesib) CAS:885060-09-3

Filanesib,also known as ARRY-520,is a synthetic,small molecule targeting the kinesin spindle protein(KSP)with potential antineoplastic activity.KSP inhibitor ARRY-520 specifically inhibits KSP(kinesin-5 or Eg5),resulting in activation of the spindle assembly checkpoint,induction of cell cycle arrest during the mitotic phase,and consequently cell death in tumor cells that are actively dividing.KSP is an ATP-dependent microtubule motor protein that is essential for the formation of bipolar spindles and the proper segregation of sister chromatids during mitosis.

msds---Arry-520 (Filanesib)