AM580 CAS:102121-60-8

AM-580 is a potent RARalpha agonist.AM580 has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells.AM580 inhibited the wnt pathway,measured by loss of nuclear beta-catenin,suggesting partial oncogene dependence of therapy.Am580 treatment increased RARbeta and lowered the level of RARgamma,an isotype whose expression we linked with tumor proliferation. 

msds---AM580