Product synthetic-chemistry-protac-linker

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Catalog	name	Description	price
R-C-937	Methyltetrazine-OH	(6-Methyl-1,2,4,5-tetrazin-3-yl)phenol is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.	price>
R-M-2063	APN-C3-PEG4-azide,Cas:2183440-32-4	APN-C3-PEG4-azide is a heterobifunctional linker containing an APN moiety with exquisite chemoselectivity for cysteine and an azide group. The superior stability of APN-cysteine conjugates in aqueous media, human plasma, and living cells makes this new thiol-click reaction a promising methodology for applications in bioconjugation.	price>
R-M-2064	APN-C3-PEG5-acid	A new class of thiol-specific conjugation reagents consisting of a thiol-reactive 3-arylpropiolonitrile (APN) group, with good stability in aqueous media. The APN group allows the targeted coupling of thiols in biomolecules, and results in stable thioether linkages without the risk of subsequent side reactions that can occur with maleimides.	price>
R-M-2065	APN-amine,Cas:1539292-61-9	APN-NH2 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.	price>
R-M-2066	APN-NH-Boc,Cas:1539292-60-8	APN-NH-Boc is a heterobifunctional linker containing an APN moiety with exquisite chemoselectivity for cysteine and Boc group. The superior stability of APN-cysteine conjugates in aqueous media, human plasma, and living cells makes this new thiol-click reaction a promising methodology for applications in bioconjugation.	price>
R-M-2070	Boc-Val-Cit,Cas:870487-08-4	Boc-Val-Cit is a cleavable ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. Boc group can be removed under acidic condition.	price>
R-M-2071	Boc-Val-Cit-PAB,Cas:870487-09-5	Boc-Val-Cit-PAB is a cleavable ADC linker. The Val-Cit peptide will specifically be cleaved by Cathepsin B. Boc group can be removed under acidic condition.	price>
R-M-2073	Diketone-PEG11-Diketone,Cas:2353409-87-5	Diketone-PEG11-Diketone is a linker for bio-conjugation that contains two terminal diketone groups linked through a linear PEG chain.	price>
R-M-2074	Diketone-PEG4-PFP ester,Cas:2353409-84-2	Diketone-PEG4-PFP ester is a PEG linker containing a diketone group and a PFP ester group, an activated ester that reacts with primary amines to form amide bonds. PFP ester has been found to be more stable than other amine reactive groups because it is less likely to undergo hydrolysis. The hydrophilic PEG spacer increases solubility in aqueous media.	price>
R-M-2075	Fmoc-Val-Cit-PAB-OH,Cas:159858-22-7	Fmoc-Val-Cit-PAB-OH is a cleavable ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. Fmoc can be deprotected under basic condition.	price>

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