R-C-5575 |
DOPA-PEG-Angiope |
1,2-Dioleoyl-sn-glycero-3-PA is a phospholipid containing the long-chain (18:1) fatty acid oleic acid inserted at the sn-1 and sn-2 positions. It has been used in the generation of micelles, liposomes, and other artificial membranes.Angiopep-2 was originally identified through phage display, a technique used to identify peptides with specific binding properties. It has been found to bind to the low-density lipoprotein receptor-related protein-1 (LRP-1), which is expressed on the luminal side of brain capillary endothelial cells. By binding to LRP-1, Angiopep-2 can undergo receptor-mediated transcytosis, a process that allows it to cross the BBB. |
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