Product peptide-fluorescent-peptide

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Catalog	name	Description	price
R-M-1183	6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) trifluoroacetate salt,CAS:1927927-42-1	This ShK analog containing a fluorescein-6-carboxyl group attached through an {2-[2-aminoethoxy]ethoxy}acetic acid (AEEAc) linker to the ƒ-amino group of Arg¹, selectively blocked the voltage gated T-lymphocyte K⁺ Kv1.3 channels implicated in the pathogenesis of experimental autoimmune encephalomyelitis. 6-FAM-AEEAc-Stichodactyla helianthus neurotoxin (ShK) may therefore be a useful tool to detect the presence of T-lymphocytes with high expression of Kv1.3 channels in normal and diseased tissues.	price>
R-M-1261	Z-Leu-Arg-Gly-Gly-AMC acetate salt,CAS:167698-68-2	Z-LRGG-AMC is a fluorogenic substrate for isopeptidase T (IPaseT) and other ubiquitin C-terminal hydrolases (UCHs) based on the C-termini of ubiquitin with a kcat/Km value of 18 M⁻¹s⁻¹. Together with our product I-1690 it forms the basis of continuous assays for precise mechanistic studies or microtiter plate assays for high-throughput inhibitor screening. LRGG is the preferred substrate sequence of the human deSUMOylating enzymes SENP6 and 7.	price>
R-M-1521	(N-Cbz-Nle-KRR)2-[Rh110]	Fluorogenic peptide substrate for flavivirus non-structural 3 (NS3) and non-structural 2B/3 (NS2B/3); This peptide therefore allows for the quantification of NS3/ NS2B/3 serine protease activity.Rhodamine 110 is a widely used red fluorescent probe.	price>
R-M-1522	(PFR)2-[Rh110]	Soybean trypsin inhibitor inhibits trypsin, factor Xa, plasmin, and plasma kallikrein activity in serum-free cell culture media. It does not inhibit metallo-, cysteine, aspartic proteases, or tissue kallikrein (serine proteases).Kallikreins (KLKs) are a large family of secreted serine proteases with either trypsin-like or chymotrypsin-like specificity which carry out many biological functions. The KLK proteases are involved in pathways that regulate skin desquamation, tooth enamel formation, kidney function, seminal liquefaction, synaptic neural plasticity, and brain function. Disruptions in the function of KLK activity has been linked to several pathologies, including respiratory diseases, neurodegeneration, anxiety, schizophrenia, skin-barrier dysfunction, pathological inflammation, and cancer.	price>
R-M-1526	(RFR)4XB	Cell penetrating peptide with a repeating motif of cationic-nonpolar-cationic (C-N-C) residues, such repeating motifs are important features of membrane-penetrating peptides. This peptide is able to enhance the efficacy and uptake of peptide phosphorodiamidate morpholino oligomers (PPMOs) into bacterial cells. PPMOs are synthetic DNA mimics that bind cRNA and inhibit bacterial gene expression, however these antisense oligomers need help crossing the outer membrane of Gram-negative bacteria due to their molecular weight and polar characteristics. Cell penetrating peptide such as this, when attached to antisense oligomers can improve their entry into Gram-negative bacteria and increased their potency by orders of magnitude.	price>
R-M-1527	(Tos-GFHR)2-[Rh110]	Candidate peptide substrate for kallikrein-related peptidase 5 (KLK5). In its intact state this peptide is not fluorescent, however when this substrate peptide is cleaved, Rhodamine 110 is released and thus fluorescence can then be detected.Contains rhodamine 110 group, a widely used red fluorescent tag. The terminal carboxylic acids in this peptide have been activated by the addition of the p-tosyl moiety, allowing for easy addition of functional groups or further peptide residues.	price>
R-M-1528	Ac-PAL-AMC,CAS : 1431362-79-6	This fluorogenic peptide substrate can be used to monitor 20S Immunoproteasome activity. The peptide is hydrolyzed by the Immunoproteasome ß1i/LMP2 subunit, but not effectively cleaved by constitutive 20S Proteasomes.	price>
R-M-1529	ACE2 α1 Helix Sequence IEEQAKTFLDKFNHEAEDLFYQS	ACE2 peptidase domain (PD) α1 helix is important for binding SARS-CoV-2-RBD of the Spike (S) protein. The 23 residues selected from the ACE2 α1 helix sequence (IEEQAKTFLDKFNHEAEDLFYQS) specifically recognizes the SARS-CoV-2-RBD with sub-nanomolar binding. Binding by this peptide to the SARS-CoV-2-RBD may block the entry of the virus into the host cell.	price>
R-M-1589	BIM (FITC)	This Bim apoptotic peptide belongs to the Bcl-2 protein family.	price>
R-M-3013	(Z-Asp-Glu-Val-Asp)2-Rhodamine 110,Cas:223538-61-2	(Z-Asp-Glu-Val-Asp)2-Rhodamine 110 is a sensitive fluorogenic substrate for the determination of caspase-3 activity.	price>

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