Catalog |
name |
Description |
price |
R-M2-9593 |
DBCO-NOTA |
DBCO-NOTA,Dibenzocyclooctyne-NOTA can be used to label biological targeting molecules with radiometals (e.g., gallium-68) for PET imaging.The DBCO-NOTA conjugate allows for the selective labeling of biomolecules without interfering with their biological functions. |
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R-M-7081 |
DBCO-C6-NH2 |
DBCO-C6-NH2 is an analog of DBCO-NH2 with an extended 6-carbon atom spacer arm. The extended 6-carbon atom spacer arm improves its derivatization efficiency and the stability of the yielded conjugates. This spacer arm also improves solubility in organic solvents such as dichloromethane, chloroform, THF, and ethyl acetate. DBCO is commonly used for copper-free Click Chemistry reactions. |
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R-M-7082 |
DBCO-SS-NHS |
Dibenzocyclooctyne (dbco) was used in the azido alkyne cycloaddition (spaac) reaction without copper ion catalysis. The kinetic constant of the second order reaction was 1.Dbco series products include dbco acid,dbco amine,dbco peg NHS,dbco peg amine, as well as dbco labeled biotin,fluorescent dyes and biochemical small molecules. |
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R-M2-9621 |
DOX-TCO |
DOX-TCO,Doxorubicin-TCO can design drug delivery systems that enable the drug to be selectively activated or released at tumor sites. This helps reduce systemic toxicity and improve therapeutic efficacy.
The TCO moiety allows for bioorthogonal reactions, where the doxorubicin can be selectively released or activated in the presence of specific partners (like tetrazines) within biological systems. This enables very precise timing and location of drug action.
Doxorubicin-TCO conjugates are part of ongoing research aimed at improving the delivery methods of chemotherapeutic agents. |
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R-M2-9622 |
CPT-TCO |
CPT-TCO,Camptothecin-TCO can be designed for various tumor types by incorporating specific ligands on the drug delivery vehicle that are recognized by receptors overexpressed in particular tumors. This increases the localization of the drug to cancer cells while sparing normal tissues.
The conjugation of camptothecin with TCO allows for the selective targeting of cancer cells. The camptothecin-TCO can remain inactive until it is brought to the site of the tumor and is reacted with a tetrazine (or another Diels-Alder partner), leading to the release of the active drug form. This reduces systemic toxicity and enhances treatment specificity.Utilizing bioorthogonal reactions not only allows for drug delivery but also enables the potential for tracking the distribution and accumulation of the drug within the body using imaging techniques. This dual function can greatly enhance therapeutic efficacy and patient monitoring during cancer treatment. |
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R-M2-9623 |
PTX-TCO |
The incorporation of TCO into the paclitaxel molecule provides a way to direct the delivery of the drug to tumor sites. When the TCO is reacted with a Diels-Alder partner, such as a tetrazine, at the site of a tumor, paclitaxel can be released in a controlled manner. This targeting helps to minimize the exposure of non-cancerous tissues to the drug, reducing side effects.
The bioorthogonal nature of the TCO moiety allows for the possibility of using imaging agents in conjunction with paclitaxel-TCO conjugates. This dual functionality can enable real-time tracking of drug distribution and bioavailability within the body, helping clinicians monitor the efficacy of chemotherapy treatments. |
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R-M1-8001 |
DBCO-PEG350-FA |
Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.
DBCO-PEG-FA can go Click Chemistry reaction without a needof any catalysts. |
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R-M1-8003 |
Dibenzocycolctyne-PEG750-Folic Acid |
DBCO-PEG-FA can go Click Chemistry reaction without a needof any catalysts.Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
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R-M1-8015 |
TCO-sialic acid |
TCO-sialic acid,trans-cyclooctene -sialic acid a bifunctional chelator. |
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R-M1-8084 |
DBCO-mannose |
DBCO-mannose,Dibenzoazacyclooctyne-mannose is a click chemical compound. |
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