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Catalog	name	Description	price
R-C-3104	PYR-41 CAS:418805-02-4	PYR-41 is the first cell-permeable inhibitor of ubiquitin-activating enzyme E1, with no activity at E2.PYR-41 induce apoptosis.	price>
R-R-4774	Holomycin CAS No.488-04-0	Holomycin/CAS No.488-04-0 is a secondary metabolite of the dithiolopyrrolone class. Holomycin also is a broad spectrum antibiotic. Holomycin has antitumor activity and can act in vivo on RNA synthesis.	price>
R-C-3105	BAY 11-7082 (BAY 11-7821) CAS:19542-67-7	BAY 11-7082(BAY 11-7821)is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10μM in tumor cells. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 with IC50 of 0.19 μM and 0.96 μM,respectively.BAY 11-7082 induces apoptosis and S phase arrest in gastric cancer cells.	price>
R-R-4775	2-Deoxyadenosine 5-di-phos-phate disodium CAS No.72003-83-9	2-Deoxyadenosine 5-di-phos-phate disodium (dADP disodium)/CAS No.72003-83-9 is an inhibitor of bacterial poly(A) polymerase. It can be used to synthesize deoxyadenosine oligonucleotides with Escherichia coli polynucleotide phosphorylase and other enzymes.	price>
R-C-3106	TZ9 CAS:1002789-86-7	TZ9 is a novel inhibitor of Rad6 ubiquitin conjugating enzyme(E2 enzyme); inhibits MDA-MB-231 cell proliferation with IC50 of ~6 uM.	price>
R-R-4776	Capecitabine-d11 CAS No.1132662-08-8	Capecitabine-d11/CAS No.1132662-08-8 is the deuterium labeled Capecitabine. Capecitabine is an oral proagent that is converted to its active metabolite, 5-FU, by thymidine phosphorylase.	price>
R-C-3107	HLI-98C CAS:317326-90-2	HLI-98C,an analog,indeed inhibited Mdm2 E3 ligase activity.	price>
R-R-4777	N6-Methyl-dA phosphoramidite CAS No.105931-58-6	N6-Methyl-dA phosphoramidite/CAS No.105931-58-6 can be used in the synthesis of oligodeoxyribonucleotides.	price>
R-C-3108	TAME CAS:901-47-3	TAME is a small molecule anaphase-promoting complex/cyclosome(APC)inhibitor with an IC50 of 12μM.	price>
R-R-4778	Werner syndrome RecQ helicase-IN-2 CAS No.2869954-51-6	Werner syndrome RecQ helicase-IN-2 (example 57)/CAS No.2869954-51-6 is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor and can be used in cancer research.	price>
R-C-3109	SMER3 CAS:67200-34-4	SMER3 is a selective inhibitor of a yeast SCF family E3 ubiquitin ligase(SCFMet30)in vitro and in vivo. Induces the expression of MET genes;blocks cell proliferation.	price>
R-R-4779	3-Isomangostin CAS No.19275-46-8	3-Isomangostin/CAS No.19275-46-8, extracted from Garciniamangostana.L. shell, is a potent MutT homologue 1 (MTH1) inhibitor with an IC50 value of 52 nM. 3-Isomangostin would be an attractive chemical tool for the development of anticancer agents.	price>
R-R-4780	Risdiplam-d4	Risdiplam-d4 is deuterium labeled Risdiplam. Risdiplam (RG7916) is an orally administered, centrally and peripherally distributed SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels.	price>
R-C-3111	SJB3-019A CAS: 2070015-29-9	SJB3-019A,also known as SJB 019, is a USP1 inhibitor.	price>
R-R-4781	5-Iminodaunorubicin hydrochloride CAS No.67324-99-6	5-Iminodaunorubicin hydrochloride/CAS No.67324-99-6 is a quinone-modified anthracycline that retains antitumor activity. 5-Iminodaunorubicin hydrochloride produces protein-concealed DNA strand breaks in cancer cells.	price>
R-C-3112	DUBs-IN-1 CAS:924296-18-4	DUBs-IN-1 is a potent deubiquitinase enzyme inhibitor with IC50s of 18 uM/0.71 uM for USP7/USP8 respectively.	price>
R-R-4782	Saccharin 1-methylimidazole CAS No.482333-74-4	Saccharin 1-methylimidazole/CAS No.482333-74-4 is an activator for DNA/RNA Synthesis.	price>
R-C-3113	DUBs-IN-3 CAS：924296-17-3	DUBs-IN-3 is a potent deubiquitinase enzyme inhibitor with IC50s of 3.1uM for USP8;>30 fold selectivity over USP7 (IC50>100uM).	price>
R-R-4783	Cytidine-5-triphosphate-d14 disodium	Cytidine-5-triphosphate-d14 (disodium) is the deuterium labeled Cytidine-5-triphosphate. Cytidine 5-triphosphate (Cytidine triphosphate;5-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5-triphosphate from uridine 5-triphosphate (UTP). Cytidine 5-triphosphate is an essential biomolecule in the de novo pyrimidine biosynthetic pathway in T. gondii.	price>
R-C-3114	GNE-6640 CAS：2009273-67-8	GNE-6640 is a selective and non-covalent inhibitor of ubiquitin epecific peptidase 7 (USP7), with IC50 values of 0.75 μM,0.43 μM,20.3μM and 0.23μM for full length USP7, USP7 catalytic domain, full length USP43 and Ub-MDM2,respectively.	price>

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