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Catalog	name	Description	price
R-R-4432	(S)-Ceralasertib CAS No.1352226-87-9	(S)-Ceralasertib ((S)-AZD6738)/CAS No.1352226-87-9 is extracted from patent WO2011154737A1, Compound II, exhibits an IC50 of 2.578 nM. (S)-Ceralasertib is a potent and selective sulfoximine morpholinopyrimidine ATR inhibitor with excellent preclinical physicochemical and pharmacokinetic (PK) characteristics. (S)-Ceralasertib is developed improving aqueous solubility and eliminates CYP3A4 time-dependent inhibition.	price>
R-C-2733	MPPC	Pharmaceutical excipients,synthetic phospholipids(1-myristoyl-2-palmitoyl-sn-glycoro-3-phosphotidylcholine)were customized and synthesized in Ruixi BiotechCo.,Ltd.	price>
R-R-4433	AZ32 CAS No.2288709-96-4	AZ32/CAS No.2288709-96-4 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.	price>
R-C-2734	A939572 CAS：1032229-33-6	A939572 is a potent,and orally bioavailable stearoyl-CoA desaturase1(SCD1)inhibitor with IC50 values of <4nM and 37nM for mSCD1 and hSCD1,respectively.	price>
R-R-4434	NU6027 CAS No.220036-08-8	NU6027/CAS No.220036-08-8 is a potent and ATP-competitive inhibitor of both CDK1 and CDK2, with Kis of 2.5 µM and 1.3 µM, respectively. NU6027 is also a potent inhibitor of ATR and enhances hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner.	price>
R-C-2735	Telotristat CAS：1033805-28-5	Telotristat(LP-778902)is the acid form of Telotristat ethyl,and the active metabolite of LX1606(Telotristat etiprate),which is an orally bioavailable, small-molecule,tryptophan hydroxylase(TPH)inhibitor and serotonin synthesis inhibitor with potential antiserotonergic activity.	price>
R-R-4435	Elimusertib-d3	Elimusertib-d3 (BAY 1895344-d3) is the deuterium labeled Elimusertib (BAY 1895344). Elimusertib is a potent, orally active and selective ATR inhibitor and has anti-tumor activity.	price>
R-C-2736	Dafadine-A CAS:1065506-69-5	Dafadine-A,an analog of dafadine, is a novel inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans; also inhibits the mammalian ortholog of DAF-9(CYP27A1).	price>
R-R-4436	KU 59403 CAS No.845932-30-1	KU 59403/CAS No.845932-30-1 is a potent ATM inhibitor, with IC50 values of 3 nM, 9.1 μM and 10 μM for ATM, DNA-PK and PI3K, respectively.	price>
R-C-2737	Indoximod (NLG-8189) CAS:110117-83-4	Indoximod(1-Methyl-D-tryptophan;NLG-8189)is an indoleamine 2,3-dioxygenase(IDO)pathway inhibitor with a Ki of 19μM.	price>
R-R-4437	SKLB-197 CAS No.2713577-16-1	SKLB-197/CAS No.2713577-16-1 showed an IC50 value of 0.013 μM against ATR but very weak or no activity against other 402 protein kinases. It displayed potent antitumor activity against ATM-deficent tumors both in vitro and in vivo.	price>
R-C-2738	Tunicamycin CAS:11089-65-9	Tunicamycin is a mixture of homologous nucleoside antibiotic that inhibits N-linked glycosylation and blocks GlcNAc phosphotransferase(GPT).Tunicamycin causes accumulation of unfolded proteins in cell endoplasmic reticulum(ER)and induces ER stress,and causes blocking of DNA synthesis and cell cycle arrest in G1 phase.	price>
R-R-4438	ATR-IN-4 CAS No.2574545-45-0	ATR-IN-4/CAS No.2574545-45-0 is a potent ATR (Ataxia telangiectasia mutated gene Rad 3-associated kinase) inhibitor. ATR-IN-4 inhibits growth of human prostate cancer cells DU145 and human lung cancer cells NCI-H460 with IC50s of 130.9 nM and 41 .33 nM, respectively. (Patent CN112142744A, compound 13).	price>
R-C-2739	PF-04620110 CAS:1109276-89-2	PF-04620110 is a potent,selective and orally bioavailable diglyceride acyltransferase-1(DGAT-1)inhibitor with an IC50 of 19nM.	price>
R-R-4439	Tozasertib CAS No.639089-54-6	Tozasertib (VX 680; MK-0457)/CAS No.639089-54-6 is an inhibitor of Aurora A/B/C kinases with Kis of 0.6, 18, 4.6 nM, respectively.	price>
R-C-2740	VER 155008 CAS:1134156-31-2	VER-155008 is an inhibitor of Hsp70,with IC50s of 0.5μM,2.6μM,and 2.6μM for Hsp70,Hsc70 and Grp7,respectively,and with a Kd of 0.3μM for Hsp70.	price>
R-R-4440	JAB-2485 CAS No.2899209-55-1	JAB-2485/CAS No.2899209-55-1 is a potent and selective Aurora kinase A (AURKA) inhibitor, with an IC50 of 0.33 nM. JAB-2485 exhibits around 1700-fold selectivity for AURKA over AURKB. JAB-2485 induces cell cycle arrest and apoptosis. JAB-2485 can be used for the research of cancer.	price>
R-C-2741	TAK 21d CAS:1143578-94-2	TAK-21d is a potent FAAH Inhibitor.	price>
R-R-4441	Hesperadin CAS No.422513-13-1	Hesperadin/CAS No.422513-13-1 is an ATP competitive indolinone inhibitor of Aurora A and B. Hesperadin inhibits Aurora B with an IC50 of 250 nM. Hesperadin inhibits the growth of Trypanosoma brucei by blocking nuclear division and cytokinesis. Hesperadin also is a broad-spectrum influenza antiviral.	price>
R-C-2742	XL-888 CAS:1149705-71-4	XL888 is an orally bioavailable,ATP-competitive,small-molecule inhibitor of heat shock protein 90(Hsp90)with potential antineoplastic activity.	price>

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