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Catalog	name	Description	price
R-R-4465	AKI603 CAS No.1432515-73-5	AKI603/CAS No.1432515-73-5 is an inhibitor of Aurora kinase A (AurA), with an IC50 of 12.3 nM. AKI603 is developed to overcome resistance mediated by BCR-ABL-T315I mutation. AKI603 exhibits strong anti-proliferative activity in leukemic cells.	price>
R-R-4466	Tinengotinib CAS No.2230490-29-4	Tinengotinib/CAS No.2230490-29-4 is the modulator of one or more protein kinases such as Aurora kinase and VEGFR kinase. Tinengotinib has the potential for the research of these kinase abnormalities diseases mediated, especially cancer-related diseases (extracted from patent WO2018108079A1).	price>
R-C-2767	YM 511 CAS:148869-05-0	Orally active,potent aromatase(CYP19)inhibitor(IC50 values are 0.4 and 0.12nM at rat ovary and human placenta cells respectively)that only weakly inhibits the synthesis of other steroid hormones.Reduces plasma estrogen levels into ranges induced by ovariectomy and inhibits testosterone-induced breast cancer cell growth in vitro(IC50=0.13nM).	price>
R-R-4467	Aurora kinase inhibitor-8 CAS No.2133001-88-2	Aurora kinase inhibitor-8/CAS No.2133001-88-2 is a highly selective inhibitor of the Aurora kinases.	price>
R-C-2768	PDN01791 CAS:149301-79-1	PDN01791（Arachidonyl Trifluoromethyl Ketone）is an analog of arachidonic acid in which the carboxyl group is replaced by a trifluoromethyl ketone group.It inhibits the activity of the 85 kDa cPLA2 and the 80 kDa macrophage iPLA2 without altering the activity of the 14 kDa sPLA2s.	price>
R-R-4468	TC-A 2317 hydrochloride CAS No.1245907-03-2	TC-A 2317 hydrochloride/CAS No.1245907-03-2 is an orally active Aurora A kinase inhibitor (Ki=1.2 nM). TC-A 2317 hydrochloride exhibits excellent selectivity to Aurora B kinase (Ki=101 nM) and other 60 kinases, good cell permeability and good PK profile. Antitumor activity.	price>
R-C-2769	MOG (35-55) CAS:149635-73-4	Myelin oligodendrocyte glycoprotein(MOG)35-55 is a minor component of CNS myelin.Produces a relapsing-remitting neurological disease with extensive plaque-like demyelination,common to the manifestations of multiple sclerosis.Induces strong T and B cell responses and is highly encephalitogenic.	price>
R-R-4469	Aurora Kinases-IN-3 CAS No.2840558-83-8	Aurora Kinases-IN-3 (Compound 15a)/CAS No.2840558-83-8 is an orally active AURKB inhibitor that elicits an AURKB-suppressive activity by disrupting the mitotic localization of AURKB, rather than inhibiting its phosphorylation of H3 at Ser10.	price>
R-C-2770	JJKK 048 CAS:1515855-97-6	JJKK 048 is an ultrapotent and highly selective inhibitor of Monoacylglycerol lipase(MAGL).	price>
R-R-4470	SCH-1473759 CAS No.1094069-99-4	SCH-1473759/CAS No.1094069-99-4 is an aurora inhibitor with IC50s of 4 and 13 nM for aurora A and B, respectively.	price>
R-C-2771	Cilomilast CAS:153259-65-5	Cilomilast(SB-207499)is a potent,selective and orally active inhibitor of Phosphodiesterase 4(PDE4),with IC50s of ~100 and 120nM for LPDE4 and HPDE4,respectively.Cilomilast shows selectivity for PDE4 over PDE1,PDE2,PDE3 and PDE5(IC50=74,65,>100,and 83µM,respectively).	price>
R-R-4471	AAPK-25 CAS No.2247919-28-2	AAPK-25/CAS No.2247919-28-2 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in a prometaphase, reflecting by the biomarker histone H3Ser10 phosphorylation and followed by a surge in apoptosis. AAPK-25 targets Aurora-A, -B, and -C with Kd values ranging from 23-289 nM, as well as PLK-1, -2, and -3 with Kd values ranging from 55-456 nM.	price>
R-C-2772	DMP 777 CAS:157341-41-8	DMP-777(L 694458)is a potent and orally active Leukocyte elastase(HLE)inhibitor.Oral dosing with DMP 777 caused a rapid increase in serum gastrin levels and severe hypochlorhydria.DMP 777 inhibited aminopyrine accumulation into rabbit parietal cells stimulated with either histamine or forskolin.	price>
R-R-4472	SJ3149 CAS No.3026986-17-1	SJ3149/CAS No.3026986-17-1 is a selective and potent degrader of CK1α protein in vitro and in vivo. SJ3149 has antitumor activity.	price>
R-C-2773	A-867744 CAS:1000279-69-5	A-867744 is a highly potent and selective type II positive allosteric modulator(PAM)of the alpha7 nicotinic acetylcholine receptors(nAChR)with an EC50 of 1.0μM.	price>
R-R-4473	DEG-77 CAS No.3032265-06-5	DEG-77/CAS No.3032265-06-5, a PROTAC based IKZF2 and CK1α degrader, possesses suitable pharmacokinetic properties, solubility, and selectivity for in vivo studies (t1/2=8h).	price>
R-C-2774	Desloratadine CAS:100643-71-8	Desloratadine(Sch34117)is the orally active major metabolite of the nonsedating H1-antihistamine Loratadine.Desloratadine is a selective H1-receptor antagonist that has anti-allergic and anti-inflammatory activities.	price>
R-R-4474	TMX-4116 CAS No.2766385-56-0	TMX-4116/CAS No.2766385-56-0 is a casein kinase 1α (CK1α) degrader. TMX-4116 shows the degradation preference for CK1α with DC50s less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4116 can be used for the research of multiple myeloma.	price>
R-C-2775	Rotundine CAS:483-14-7	Rotundine(L-tetrahydropalmatine,L-THP)is a selective dopamine D1 receptor antagonist with IC50 of 166nM.	price>
R-R-4475	Silmitasertib sodium salt CAS No.1309357-15-0	Silmitasertib sodium salt/CAS No.1309357-15-0 is an orally bioavailable, highly selective and potent CK2 inhibitor, with IC50 values of 1 nM against CK2α and CK2α.	price>

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