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Catalog	name	Description	price
R-R-4490	CK2/ERK8-IN-1 CAS No.1085822-09-8	CK2/ERK8-IN-1/CAS No.1085822-09-8 is a dual casein kinase 2 (CK2) (Ki of 0.25 µM) and ERK8 (MAPK15, ERK7) inhibitor with IC50s of 0.50 μM. CK2/ERK8-IN-1 also binds to PIM1, HIPK2 (homeodomain-interacting protein kinase 2), and DYRK1A with Kis of 8.65 µM, 15.25 µM, and 11.9 µM, respectively. CK2/ERK8-IN-1 has pro-apoptotic efficacy.	price>
R-C-2791	Iguratimod CAS:123663-49-0	Iguratimod is an antirheumatic agent,acts as an inhibitor of COX-2,with an IC50 of 20μM(7.7μg/mL),but shows no effect on COX-1.Iguratimod also inhibits macrophage migration inhibitory factor(MIF)with an IC50 of 6.81μM.	price>
R-R-4491	Epiblastin A CAS No.16470-02-3	Epiblastin A/CAS No.16470-02-3 is an ATP competitive casein kinase 1 (CK1) inhibitor with IC50s of 8.9, 0.5, and 4.7 µM for CK1α, CK1δ, and CK1 ɛ, respectively. Epiblastin A induces reprogramming of epiblast stem cells into embryonic stem cells by inhibition of CK1.	price>
R-C-2792	TCN 238 CAS:125404-04-8	TCN238 is an orally bioavailable mGlu4 receptor positive allosteric modulator (PAM)with an EC50 of 1μM.	price>
R-C-3322	DSPE-PEG550-RGD(ARG-GLY-ASP)	Phospholipid polyethylene glycol RGD can be used for passive targeting,active targeting and drug delivery of micelles and vesicles.DSPE is a saturated 18 carbon phospholipid,which is commonly used in the synthesis of liposomes. Polyethylene glycol (PEG)-coupled DSPE is hydrophilic and can be used for drug delivery,gene transfection and biomolecular modification.PEGylation of phospholipid significantly improved the blood circulation time and stability of capsule drugs.Polyethylene glycol can enhance solubility and stability,reduce the surface nonspecific binding of charged molecules,and reduce the immunogenicity of peptides.	price>
R-R-4492	MRT00033659 CAS No.1401731-54-1	MRT00033659/CAS No.1401731-54-1 is a potent broad-spectrum kinase inhibitor of CK1 (IC50=0.9 µM for CK1δ) and CHK1 (IC50=0.23 µM). MRT00033659, a pyrazolo-pyridine analogue, induces p53 pathway activation and E2F-1 destabilisation.	price>
R-C-2793	RuBi-Nicotine CAS:1256362-30-7	Ruthenium-bisbipyridine-caged nicotine,excitable by irradiation with visible light.Undergoes rapid photolysis to release nicotine(<20 ns);exhibits a high quantum yield.Induces action potential propagation in Retzius neurons of leech ganglia with no detectable toxicity at a concentration of 1mM.	price>
R-C-3323	DSPE-PEG750-RGD(ARG-GLY-ASP)	Phospholipid polyethylene glycol RGD can be used for passive targeting,active targeting and drug delivery of micelles and vesicles.DSPE is a saturated 18 carbon phospholipid,which is commonly used in the synthesis of liposomes. Polyethylene glycol (PEG)-coupled DSPE is hydrophilic and can be used for drug delivery,gene transfection and biomolecular modification.PEGylation of phospholipid significantly improved the blood circulation time and stability of capsule drugs.Polyethylene glycol can enhance solubility and stability,reduce the surface nonspecific binding of charged molecules,and reduce the immunogenicity of peptides.	price>
R-R-4493	TMX-4113 CAS No.2766385-92-4	TMX-4113/CAS No.2766385-92-4 is a degrader of phosphodiesterase 6D (PDE6D) and casein kinase 1α (CK1α). TMX-4113 can be used for the research of cancer.	price>
R-C-2794	VU 0360223 CAS:1274859-33-4	Potent negative allosteric modulator of mGlu5(IC50=61nM).Displays no activity at mGlu1-4 and mGlu7-8.	price>
R-C-3324	DSPE-PEG350-BTC	In order to improve the accumulation of anticancer drugs in tumor and enhance the possibility of intracellular delivery,the stealth liposomes modified with arginine glycine aspartic acid (RGD) mimics were used as targeting vectors. Integrin was synthesized and covalently coupled with active polyethylene glycol phospholipid(DSPE-PEG-BTC) to form rgdm coupling compound (DSPE-PEG-RGDM).The binding of melanoma cells to dspe-peg-rgdm was studied by pH sensitive probe bcecf-am.	price>
R-R-4494	LH846 CAS No.639052-78-1	LH846/CAS No.639052-78-1 is a selective inhibitor of CKIδ, with an IC50 of 290 nM, and less potently inhibits CKIα and CKIε, with IC50s of 2.5 μM and 1.3 μM, respectively.	price>
R-C-2795	Alcaftadine (R89674) CAS:147084-10-4	Alcaftadine(R89674)is a histamine H1 receptor antagonist,which is used to prevent eye irritation brought on by allergic conjunctivitis.Alcaftadine is a broad-spectrum antihistamine displaying a high affinity for histamine H1 and H2 receptors and a lower affinity for H4 receptors.Alcaftadine also exhibits modulatory action on immune cell recruitment and mast cell stabilizing effects.	price>
R-C-3325	DSPE-PEG550-BTC	In order to improve the accumulation of anticancer drugs in tumor and enhance the possibility of intracellular delivery,the stealth liposomes modified with arginine glycine aspartic acid (RGD) mimics were used as targeting vectors. Integrin was synthesized and covalently coupled with active polyethylene glycol phospholipid(DSPE-PEG-BTC) to form rgdm coupling compound (DSPE-PEG-RGDM).The binding of melanoma cells to dspe-peg-rgdm was studied by pH sensitive probe bcecf-am.	price>
R-R-4495	Casein Kinase II Inhibitor IV CAS No.863598-09-8	Casein Kinase II Inhibitor IV/CAS No.863598-09-8 is a potent, ATP-competitive of casein kinase II inhibitor with an IC50 of 9 nM. Casein Kinase II Inhibitor IV ia also a human keratinocytes (NHEK) differentiation inducer.	price>
R-C-2796	Maropitant CAS:147116-67-4	Maropitant is a neurokinin(NK1)receptor antagonist.IC50 value:Target:NK1 receptor Maropitant is the first NK1 receptor antagonist developed to treat and prevent emesis in dogs.	price>
R-C-3326	DSPE-PEG750-BTC	In order to improve the accumulation of anticancer drugs in tumor and enhance the possibility of intracellular delivery,the stealth liposomes modified with arginine glycine aspartic acid (RGD) mimics were used as targeting vectors. Integrin was synthesized and covalently coupled with active polyethylene glycol phospholipid(DSPE-PEG-BTC) to form rgdm coupling compound (DSPE-PEG-RGDM).The binding of melanoma cells to dspe-peg-rgdm was studied by pH sensitive probe bcecf-am.	price>
R-R-4496	MU1742	MU1742 is a probe for CK1δ and CK1ε protein kinases.	price>
R-C-2797	L-732,138 CAS:148451-96-1	L-732138 is a selective,potent and competitive neurokinin-1(NK-1)receptor antagonist with an IC50 of 2.3nM.L-732138 has 200-fold more potent in cloned human NK-1 receptors than cloned rat NK-1 receptors,and has>1000-fold more potent than human NK-2 and NK-3 receptors.L-732138 can reduce hyperalgesia and has antitumor action.	price>
R-C-3327	DSPE-PEG350-psCPP	(DSPE) polyethyleneglycol is a combination of phospholipid and polyethylene glycol,which has hydrophilicity and hydrophobicity.Polyethylene glycol liposomes were used to form high-quality materials.It can be used for drug delivery,gene transfection and vaccine delivery.Pegylated phospholipids can significantly improve blood circulation time and stabilize drug encapsulation.These materials can also be used for targeted drug delivery by modifying the ligand with the target surface to add antibodies and peptides.	price>

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