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Catalog	name	Description	price
R-C-2750	Etomoxir CAS:124083-20-1	Etomoxir((R)-(+)-Etomoxir)is an irreversible inhibitor of carnitine palmitoyltransferase 1a(CPT-1a),inhibits fatty acid oxidation(FAO)through CPT-1a and inhibits palmitate β-oxidation in human,rat and guinea pig.	price>
R-R-4450	TCS7010 CAS No.1158838-45-9	TCS7010/CAS No.1158838-45-9 is a potent and highly selective Aurora A inhibitor with with an IC50 of 3.4 nM.	price>
R-C-2751	NMS-E973 CAS:1253584-84-7	NMS-E973 is a potent and selective inhibitor of HSP90.NMS-E973 binds to the ATP binding site of Hsp90α with a DC50 of <10nM.NMS-E973 is able to cross the blood-brain barrier(BBB).Antitumor efficacy.	price>
R-R-4451	PF 477736 CAS No.952021-60-2	PF 477736 (PF 00477736)/CAS No.952021-60-2 is a potent, selective and ATP-competitive inhibitor of Chk1, with a Ki of 0.49 nM, it is also a Chk2 inhibitor, with a Ki of 47 nM. PF 477736 shows <100-fold selectivity for Chk1 over VEGFR2, Fms, Yes, Aurora-A, FGFR3, Flt3, and Ret (IC50=8 (Ki), 10, 14, 23, 23, 25, and 39 nM, respectively). PF 477736 can enhance Gemcitabine antitumor activity in vitro and in vivo.	price>
R-C-2752	Radicicol CAS:496054-87-6	Radicicol is an inhibitor of Hsp90 with an IC50 value of 1μM.Radicicol binds to the ATPase domain of Hsp90 and prevents maturation of Hsp90 clients, leading to proteasomal degradation.Radicicol is an antifungal antibiotic with antimalarial activity,impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB.	price>
R-R-4452	Ilorasertib hydrochloride CAS No.1847485-91-9	Ilorasertib (ABT-348) hydrochloride/CAS No.1847485-91-9 is a potent, orally active and ATP-competitive aurora inhibitor with IC50s of116, 5, 1 nM for aurora A, aurora B, aurora C, respectively. Ilorasertib hydrochloride also is a potent VEGF, PDGF inhibitor. Ilorasertib hydrochloride has the potential for the research of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS).	price>
R-C-2753	SR 1664 CAS:1338259-05-4	SR1664 is a PPARγ antagonist.SR1664 binds to PPARγ and potently inhibits Cdk5-mediated PPARγ phosphorylation(IC50=80nM;Ki=28.67nM).	price>
R-R-4453	SCH-1473759 hydrochloride CAS No.1094067-13-6	SCH-1473759 hydrochloride/CAS No.1094067-13-6 is an aurora inhibitor with IC50s of 4 and 13 nM for aurora A and B, respectively.	price>
R-C-2754	Tolcapone CAS:134308-13-7	Tolcapone(Ro 40-7592)is a selective,orally active and powerful mixed(peripheral and central)COMT inhibitor with an IC50 of 773 nM in the liver.Tolcapone is also a potent inhibitor of α-syn and Aβ42 oligomerization and fibrillogenesis.Tolcapone induces oxidative stress leading to apoptosis and inhibition of tumor growth in neuroblastoma.	price>
R-R-4454	CCT129202 CAS No.942947-93-5	CCT129202/CAS No.942947-93-5 is an aurora kinase inhibitor with IC50s of 42, 198, and 227 nM for aurora A, B and C, respectively.	price>
R-C-2755	Atorvastatin Calcium CAS:134523-03-8	Potent HMG-CoA reductase inhibitor(IC50=8 nM).Reduces circulating LDL-C by inhibiting cholesterol biosynthesis and inducing expression of LDL receptors. Inhibits smooth muscle cell proliferation in vitro and exhibits antinociceptive effects in the inflammatory hypernociception model.	price>
R-R-4455	Chiauranib CAS No.1256349-48-0	Chiauranib (CS2164)/CAS No.1256349-48-0 is an orally active multi-target inhibitor against tumor angiogenesis. Chiauranib potently inhibits the angiogenesis-related kinases (VEGFR1, VEGFR2, VEGFR3, PDGFRα and c-Kit), mitosis-related kinase Aurora B, and chronic inflammation-related kinase CSF-1R, with IC50 values ranging from 1-9 nM. Chiauranib has strongly anticancer effects.	price>
R-C-2756	VT-464 racemate CAS:1375603-36-3	Seviteronel racemate(VT-464 racemate)is the racemate form of Seviteronel(VT-464),which is a potent CYP17 lyase inhibitor(h-Lyase IC50=nM)inhibition.	price>
R-R-4456	TAS-119 CAS No.1453099-83-6	TAS-119/CAS No.1453099-83-6 is a potent, selective and orally active Aurora A inhibitor with an IC50 of 1.0 nM. TAS-119 shows high selectivity for Aurora A over other protein kinases, including Aurora B (IC50 of 95 nM). TAS-119 has potent antitumor activites.	price>
R-C-2757	Brinzolamide CAS:138890-62-7	Brinzolamide(AL 4862)is a potent carbonic anhydrase II inhibitor with IC50 of 3.19nM.	price>
R-R-4457	PHA-680632 CAS No.398493-79-3	PHA-680632/CAS No.398493-79-3 is an aurora kinase inhibitor with IC50s of 27, 135 and 120 nM for aurora A, B and C, respectively.	price>
R-C-2758	PF-4981517 CAS:1390637-82-7	CYP3cide(PF-4981517)is a potent,selective and time-dependent inhibitor of cytochrome P4503A4(CYP3A4).The IC50 values for Midazolam 1-hydroxylase activity are 0.03μM,17μM,and 71μM for CYP3A4,CYP3A5, and CYP3A7,respectively.CYP3cide can be used to distinguish the contributions of CYP3A4 versus CYP3A5 on drug metabolism.	price>
R-R-4458	NU6140 CAS No.444723-13-1	NU6140/CAS No.444723-13-1 is a selective CDK2-cyclin A inhibitor (IC50, 0.41 μM), exhibits 10- to 36-fold selectivity over other CDKs. NU6140 also potently inhibits Aurora A and Aurora B, with IC50s of 67 and 35 nM, respectively. Enhances the apoptotic effect, with anti-cancer activity.	price>
R-C-2759	GSK 2830371 CAS:1404456-53-6	GSK 2830371 is a WiP1 inhibitor.It inhibits cell growth and tumor growth in lymphoma and neuroblastoma models.	price>
R-R-4459	CD532 hydrochloride CAS No.2926498-81-7	CD532 hydrochloride/CAS No.2926498-81-7 is a potent Aurora A kinase inhibitor with an IC50 of 45 nM. CD532 hydrochloride has the dual effect of blocking Aurora A kinase activity and driving degradation of MYCN. CD532 hydrochloride also can directly interact with AURKA and induces a global conformational shift. CD532 hydrochloride can be used for the research of cancer.	price>

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