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Catalog	name	Description	price
R-C-2730	MK-8245 CAS:1030612-90-8	MK-8245 is an liver-targeting inhibitor of stearoyl-CoA desaturase (SCD)with IC50 of 1 nM for human SCD1 and 3nM for both rat SCD1 and mouse SCD1,with anti-diabetic and anti-dyslipidemic efficacy.Phase 2.	price>
R-R-4430	Lartesertib CAS No.2495096-26-7	Lartesertib (M4076)/CAS No.2495096-26-7 is a potent inhibitor of serine/threonine protein kinase ATM (extracted from patent WO2022058351A1).	price>
R-C-2731	ABT-046 CAS:1031336-60-3	ABT-046 is a potent,selective,and orally efficacious acyl CoA:diacylglycerol acyltransferase 1(DGAT-1)inhibitor(IC50=8nM).	price>
R-R-4431	Ro 90-7501 CAS No.293762-45-5	Ro 90-7501/CAS No.293762-45-5 is an amyloid β42 (Aβ42) fibril assembly inhibitor that reduces Aβ42-induced cytotoxicity (EC50 of 2 μM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-β gene expression and antiviral response. Ro 90-7501 also inhibits protein phosphatase 5 (PP5) in a TPR-dependent manner. Ro 90-7501 has significant radiosensitizing effects on cervical cancer cells.	price>
R-C-2732	CS@Fe3O4 nanoparticles	The product is 30nm chitosan coated Fe3O4 magnetic nanoparticles with a large number of active amino groups on the surface and a saturation magnetization of 70-80.	price>
R-R-4432	(S)-Ceralasertib CAS No.1352226-87-9	(S)-Ceralasertib ((S)-AZD6738)/CAS No.1352226-87-9 is extracted from patent WO2011154737A1, Compound II, exhibits an IC50 of 2.578 nM. (S)-Ceralasertib is a potent and selective sulfoximine morpholinopyrimidine ATR inhibitor with excellent preclinical physicochemical and pharmacokinetic (PK) characteristics. (S)-Ceralasertib is developed improving aqueous solubility and eliminates CYP3A4 time-dependent inhibition.	price>
R-C-2733	MPPC	Pharmaceutical excipients,synthetic phospholipids(1-myristoyl-2-palmitoyl-sn-glycoro-3-phosphotidylcholine)were customized and synthesized in Ruixi BiotechCo.,Ltd.	price>
R-R-4433	AZ32 CAS No.2288709-96-4	AZ32/CAS No.2288709-96-4 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.	price>
R-C-2734	A939572 CAS：1032229-33-6	A939572 is a potent,and orally bioavailable stearoyl-CoA desaturase1(SCD1)inhibitor with IC50 values of <4nM and 37nM for mSCD1 and hSCD1,respectively.	price>
R-R-4434	NU6027 CAS No.220036-08-8	NU6027/CAS No.220036-08-8 is a potent and ATP-competitive inhibitor of both CDK1 and CDK2, with Kis of 2.5 µM and 1.3 µM, respectively. NU6027 is also a potent inhibitor of ATR and enhances hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner.	price>
R-C-2735	Telotristat CAS：1033805-28-5	Telotristat(LP-778902)is the acid form of Telotristat ethyl,and the active metabolite of LX1606(Telotristat etiprate),which is an orally bioavailable, small-molecule,tryptophan hydroxylase(TPH)inhibitor and serotonin synthesis inhibitor with potential antiserotonergic activity.	price>
R-R-4435	Elimusertib-d3	Elimusertib-d3 (BAY 1895344-d3) is the deuterium labeled Elimusertib (BAY 1895344). Elimusertib is a potent, orally active and selective ATR inhibitor and has anti-tumor activity.	price>
R-C-2736	Dafadine-A CAS:1065506-69-5	Dafadine-A,an analog of dafadine, is a novel inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans; also inhibits the mammalian ortholog of DAF-9(CYP27A1).	price>
R-R-4436	KU 59403 CAS No.845932-30-1	KU 59403/CAS No.845932-30-1 is a potent ATM inhibitor, with IC50 values of 3 nM, 9.1 μM and 10 μM for ATM, DNA-PK and PI3K, respectively.	price>
R-C-2737	Indoximod (NLG-8189) CAS:110117-83-4	Indoximod(1-Methyl-D-tryptophan;NLG-8189)is an indoleamine 2,3-dioxygenase(IDO)pathway inhibitor with a Ki of 19μM.	price>
R-R-4437	SKLB-197 CAS No.2713577-16-1	SKLB-197/CAS No.2713577-16-1 showed an IC50 value of 0.013 μM against ATR but very weak or no activity against other 402 protein kinases. It displayed potent antitumor activity against ATM-deficent tumors both in vitro and in vivo.	price>
R-C-2738	Tunicamycin CAS:11089-65-9	Tunicamycin is a mixture of homologous nucleoside antibiotic that inhibits N-linked glycosylation and blocks GlcNAc phosphotransferase(GPT).Tunicamycin causes accumulation of unfolded proteins in cell endoplasmic reticulum(ER)and induces ER stress,and causes blocking of DNA synthesis and cell cycle arrest in G1 phase.	price>
R-R-4438	ATR-IN-4 CAS No.2574545-45-0	ATR-IN-4/CAS No.2574545-45-0 is a potent ATR (Ataxia telangiectasia mutated gene Rad 3-associated kinase) inhibitor. ATR-IN-4 inhibits growth of human prostate cancer cells DU145 and human lung cancer cells NCI-H460 with IC50s of 130.9 nM and 41 .33 nM, respectively. (Patent CN112142744A, compound 13).	price>
R-C-2739	PF-04620110 CAS:1109276-89-2	PF-04620110 is a potent,selective and orally bioavailable diglyceride acyltransferase-1(DGAT-1)inhibitor with an IC50 of 19nM.	price>
R-R-4439	Tozasertib CAS No.639089-54-6	Tozasertib (VX 680; MK-0457)/CAS No.639089-54-6 is an inhibitor of Aurora A/B/C kinases with Kis of 0.6, 18, 4.6 nM, respectively.	price>

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