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Catalog	name	Description	price
R-R-4419	A-437203 CAS No.220519-06-2	A-437203/CAS No.220519-06-2 is a selective D3 receptor antagonist with Ki of 71, 1.6, and 6220 nM for D2, D3, and D4 receptors, respectively.	price>
R-C-2720	Niclosamide CAS:50-65-7	Inhibitor of the STAT3 signaling pathway;inhibits the activation,nuclear translocation and transactivation of STAT3.Displays selectivity for STAT3 over STAT1,STAT5,JAK1,JAK2 and Src kinases.Inhibits the transcription of STAT3 target genes and induces cell growth inhibition,apoptosis and cell cycle arrest of cancer cells with constitutively active STAT3.Also reversibly inhibits mTORC1 signaling and stimulates autophagy in vitro;displays antineoplastic effects in acute myelogenous leukemia(AML)stem cells.	price>
R-R-4420	7a,25-Dihydroxycholesterol CAS No.64907-22-8	7α, 25-dihydroxycholesterol (7α,25-OHC)/CAS No.64907-22-8 is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol is highly potent at activating EBI2 (EC50=140 pM; Kd=450 pM). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells.	price>
R-C-2721	NSC 74859 CAS:501919-59-1	S3I-201(NSC 74859)is a novel inhibitor of Stat3 that inhibits Stat3,Stat3 complex formation and Stat3-DNA binding activity in vitro(IC50=86±33µM)and Stat3-dependent transcriptional activities.	price>
R-R-4421	GSK682753A CAS No.1334294-76-6	GSK682753A/CAS No.1334294-76-6 is a selective and highly potent inverse agonist of the epstein-barr virus-induced receptor 2 (EBI2) with an IC50 of 53.6 nM.	price>
R-C-2722	CP-724714 CAS:537705-08-1	CP-724714 is a potent,selective and orally active ErbB2(HER2)tyrosine kinase inhibitor,with an IC50 of 10nM.CP-724714 displays a marked selectivity against EGFR kinase(IC50=6400nM).CP-724714 potently inhibits ErbB2 receptor autophosphorylation in intact cells.Antitumor activities.	price>
R-R-4422	ML401 CAS No.1597489-14-9	ML401/CAS No.1597489-14-9, a potent chemical probe, selectively antagonizes EBI2 (also known as GPR183) with an IC50 of 1.03 nM. ML401 displays activity in a chemotaxis assay (IC50=6.24 nM). ML401 shows good stability and no toxicity.	price>
R-C-2723	AC480 (BMS-599626) CAS:714971-09-2	BMS-599626(AC480)is a selective and orally bioavailable HER1 and HER2 inhibitor,with IC50s of 20 and 30nM,respectively.BMS-599626 displays~8-fold less potent to HER4(IC50=190nM),>100-fold to VEGFR2,c-Kit,Lck,MEK. BMS-599626 inhibits tumor cell proliferation,and has potential to increase tumor response to radiotherapy.	price>
R-R-4423	SAE-14 CAS No.1241280-25-0	SAE-14 (compound SAE-14)/CAS No.1241280-25-0 is a potent, specific GPR183 antagonist with an IC50 value of 28.5 nM, can antagonize 7α, 25-OHC–induced calcium mobilization with IC50 value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice.	price>
R-C-2724	Corylifol A CAS:775351-88-7	Corylifol A is a phenolic compounds isolated from Psoralea corylifolia;inhibits IL-6-induced STAT3 activation and phosphorylation(IC50=0.8uM).	price>
R-R-4424	GPR183 antagonist-2 CAS No.2924063-98-7	GPR183 antagonist-2 (compound 32)/CAS No.2924063-98-7 is a selective GPR183 antagonist with good water solubility and excellent pharmacokinetic properties. GPR183 antagonist-2 significantly reduces paw and joint swelling and gene expression of pro-inflammatory cytokines (MCP-1, MMPs, and VEGF) in a collagen-induced arthritis (CIA) mouse model in a dose-dependent manner. GPR183 antagonist-2 can be used in the study of autoimmune diseases.	price>
R-C-2725	BMS-690514 CAS:859853-30-8	BMS-690514 is a potent and selective inhibitor of epidermal growth factor receptor(EGFR),HER2,and HER4，as well as the VEGF receptor kinases.	price>
R-R-4425	AZD1390 CAS No.2089288-03-7	AZD1390/CAS No.2089288-03-7 is a potent, highly selective, orally bioavailable, brain-penetrant ATM inhibitor with an IC50 of 0.78 nM in cell.	price>
R-R-4426	Camonsertib CAS No.2417489-10-0	Camonsertib (RP-3500)/CAS No.2417489-10-0 is an orally active, selective ATR kinase inhibitor (ATRi) with an IC50 of 1.00 nM in biochemical assays. Camonsertib shows 30-fold selectivity for ATR over mTOR (IC50=120 nM) and >2,000-fold selectivity over ATM, DNA-PK, and PI3Kα kinases. Camonsertib has potent antitumor activity.	price>
R-C-2727	GSK 0660 CAS：1014691-61-2	GSK 0660 is a selective PPARβ antagonist(IC50 values are 0.155,>10 and≥10µM at PPARβ,PPARα and PPARγ respectively).	price>
R-R-4427	Elimusertib hydrochloride	Elimusertib (BAY 1895344) hydrochloride is a potent, orally active and selective ATR inhibitor with an IC50 of 7 nM. Elimusertib hydrochloride has anti-tumor activity. Elimusertib hydrochloride can be used for the research of solid tumors and lymphomas.	price>
R-C-2728	Zardaverine CAS：101975-10-4	Zardaverine is a newly developed dual-selective PDE3/4 inhibitor with IC50 values of 0.5 uM and 0.8uM respectively.	price>
R-R-4428	Gartisertib CAS No.1613191-99-3	Gartisertib (VX-803)/CAS No.1613191-99-3 is an ATP-competitive, orally active, and selective ATR inhibitor, with a Ki of <150 pM. Gartisertib potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (Chk1) phosphorylation with an IC50 of 8 nM. Antitumor activity.	price>
R-C-2729	PF-04457845 CAS:1020315-31-4	PF-04457845 is a highly efficacious and selective FAAH inhibitor with IC50 values is 7.2±0.63nM and 7.4±0.62nM for hFAAH and rFAAH,respectively.	price>
R-R-4429	Tuvusertib CAS No.1613200-51-3	Tuvusertib (M1774; ATR inhibitor 1)/CAS No.1613200-51-3 is a selective and orally active ATR inhibitor extracted from patent WO2015187451A1, compound I-l, with a Ki value below 1 μΜ.	price>

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