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Catalog	name	Description	price
R-R-4409	Cabergoline-d6 CAS No.2738376-76-4	Cabergoline-d6 is deuterium labeled Cabergoline. Cabergoline is an ergot derived-dopamine D2-like receptor agonist that has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respectively).	price>
R-C-2710	YM 750 CAS:138046-43-2	YM-750 is a potent acyl-CoA:cholesterol acyltransferase(ACAT)inhibitor(IC50=0.18 μM).ACAT catalyzes the formation of cholesteryl esters from cholesterol and long-chain fatty-acyl-coenzyme A.	price>
R-R-4410	OS-3-106 CAS No.1580000-17-4	OS-3-106/CAS No.1580000-17-4 is a potent, BBB-penetrated and selective dopamine D3 receptor (D3R) agonist. OS-3-106 binds with high affinity (Ki = 0.2 nM) at the D3R. OS-3-106 can be used for psychoactivator addiction research.	price>
R-C-2711	GSK J5 CAS:1394854-51-3	Inactive isomer of GSK J4;also cell permeable ester derivative of the inactive control,GSK J2.	price>
R-R-4411	Clomipramine-d3 hydrochloride CAS No.1398065-86-5	Clomipramine-d3 (hydrochloride)/CAS No.1398065-86-5 is a deuterium labeled Clomipramine hydrochloride. Clomipramine hydrochloride is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively.	price>
R-C-2712	WZ4002 CAS:1213269-23-8	WZ4002 is a mutant selective EGFR inhibitor with IC50s of 2,8,3 and 2nM for EGFRL858R,EGFRL858R/T790M,EGFRE746-A750 and EGFRE746-A750/T790M,respectively.	price>
R-R-4412	Fluphenazine-d8 CAS No.1323633-98-2	Fluphenazine-d8/CAS No.1323633-98-2 is the deuterium labeled Fluphenazine. Fluphenazine is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine blocks neuronal voltage-gated sodium channels. Fluphenazine acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2.	price>
R-C-2713	WZ8040 CAS:1214265-57-2	WZ8040 is an irreversible mutated EGFR T790M inhibitor and inhibits EGFR phosphorylation.WZ8040 displays 100-fold greater activity against the mutated EGFR than the normal.	price>
R-R-4413	Sonepiprazole CAS No.170858-33-0	Sonepiprazole (PNU-101387G)/CAS No.170858-33-0 is a selective D4 dopamine antagonist with Kis of 3.6, 10.1, 5147, and 7430 nM for rD4-Dopamine, hD4.2-Dopamine, rD2-Dopamine, and Histamine-H1 receptors, respectively.	price>
R-C-2714	BMS-911543 CAS:1271022-90-2	BMS-911543 is an orally available small molecule targeting a subset of Janus-associated kinase(JAK)with potential antineoplastic activity.JAK2 inhibitor BMS-911543 selectively inhibits JAK2,thereby preventing the JAK/STAT(signal transducer and activator of transcription)signaling cascade,including activation of STAT3.This may lead to an induction of tumor cell apoptosis and a decrease in cellular proliferation.	price>
R-R-4414	Haloperidol-d4-1 CAS No.136765-35-0	Haloperidol-d4-1/CAS No.136765-35-0 is deuterium labeled haloperidol, and the latter is a potent dopamine D2 receptor antagonist.	price>
R-C-2715	AZD-9291 (Osimertinib) CAS:1271022-90-2	AZD-9291 is a third-generation EGFR inhibitor,showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors.	price>
R-R-4415	Dexpramipexole-d3 dihydrochloride CAS No.1432230-09-5	Dexpramipexole-d3 (dihydrochloride)/CAS No.1432230-09-5 is the deuterium labeled Dexpramipexole. Dexpramipexole((R)-Pramipexole), also known as R-(+)-Pramipexole, is a neuroprotective agent and weak non-ergoline dopamine agonist.	price>
R-C-2716	FASN-IN-1 CAS:1808260-84-5	FASN-IN-1 is a fatty acid synthase(FASN)inhibitor extracted from patent WO2015134790A1,compound 56.	price>
R-R-4416	Molindone-d8 CAS No.1189805-13-7	Molindone-d8/CAS No.1189805-13-7 is the deuterium labeled Molindone. Molindone hydrochloride (EN-1733A) is a therapeutic antipsychotic, used in the treatment of schizophrenia, works by blocking the effects of dopamine in the brain, leading to diminished psychoses.	price>
R-C-2717	OSI-420 CAS:183320-51-6	OSI-420(Desmethyl Erlotinib,CP-473420)is an orally active EGFR tyrosin kinase inhibitor,which inhibits receptor tyrosine kinases(TKs)by inhibition of the intercellular domain .	price>
R-R-4417	Raclopride-d5 hydrochloride CAS No.1217623-85-2	Raclopride-d5 (hydrochloride)/CAS No.1217623-85-2 is the deuterium labeled Raclopride. Raclopride is a dopamine D2/D3 receptor antagonist, which binds to D2 and D3 receptors with dissociation constants (Kis) of 1.8 nM and 3.5 nM, respectively, but has a very low affinity for D1 and D4 receptors with Kis of 18000 nM and 2400 nM, respectively.	price>
R-C-2718	Butein CAS:487-52-5	Butein is a cAMP-specific PDE inhibitor with an IC50 of 10.4μM for PDE4. Butein is a specific protein tyrosine kinase inhibitor with IC50s of 16 and 65 μM for EGFR and p60c-src in HepG2 cells.Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a.Butein is a SIRT1 activator(STAC).	price>
R-R-4418	Quetiapine-d8 fumarate CAS No.1185247-12-4	Quetiapine-d8 (fumarate)/CAS No.1185247-12-4 is the deuterium labeled Quetiapine. Quetiapine is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects.	price>
R-C-2719	AEE788 (NVP-AEE788)	AEE-788 is an orally bioavailable multiple-receptor tyrosine kinase inhibitor. AEE788 inhibits phosphorylation of the tyrosine kinases of epidermal growth factor receptor(EGFR),human epidermal growth factor receptor 2(HER2),and vascular endothelial growth factor receptor 2(VEGF2),resulting in receptor inhibition, the inhibition of cellular proliferation,and induction of tumor cell and tumor-associated endothelial cell apoptosis.	price>

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