Xi'an ruixi Biological Technology Co

Home > Keywords >

Catalog	name	Description	price
R-R-4330	UCSF924 CAS No.1434515-70-4	UCSF924/CAS No.1434515-70-4 is a potent and specific dopamine D4 receptor (DRD4) partial agonist with a EC50 of 4.2 nM. UCSF924 has a high-affinity with a Ki value of 3 nM for DRD4 and shows no measurable affinity for D2, D3 or the F261V/L328F D4 mutant. UCSF924 is a 7.4-fold bias toward arrestin over Gαi/o signaling, referenced to quinpirole.	price>
R-C-2631	Sotrastaurin (AEB071) CAS:425637-18-9	Sotrastaurin(AEB071)is a potent and orally-active pan-PKC inhibitor,with Kis of 0.22 nM,0.64nM,0.95nM,1.8nM,2.1nM and 3.2nM for PKCθ,PKCβ,PKCα,PKCη,PKCδ and PKCε,respectively.	price>
R-R-4331	SKF 83959 CAS No.80751-85-5	SKF83959/CAS No.80751-85-5 is a potent and selective dopamine D1-like receptor partial agonist. SKF83959 Ki values for rat D1, D5, D2 and D3 receptors are 1.18, 7.56, 920 and 399 nM, respectively. SKF83959 is a potent allosteric modulator of sigma (σ)-1 receptor. SKF83959 belongs to benzazepine family and has improvements on cognitive dysfunction.	price>
R-C-2632	RepSox (E-616452) CAS:446859-33-2	RepSox(E-616452)is a potent and selective of the TGFβR-1/ALK5 inhibitor which inhibits ALK5 autophosphorylation with an IC50 of 4nM.	price>
R-R-4332	Roxindole hydrochloride CAS No.108050-82-4	Roxindole hydrochloride (EMD 38362)/CAS No.108050-82-4, an indot-alkyl-pipenidine, is a potent agonist at dopamine autoreceptors, with an affinity for the D2-like subtype in the low nanomolar range. Roxindole can be used for the research of positive and negative schizophrenic symptoms. Roxindole is a 5-HT1A agonist and 5-HT uptake inhibitor with high affinity for 5-HT1A (IC50=0.9 nM). Antipsychotic and antidepressant activities.	price>
R-C-2633	Epicatechin CAS:490-46-0	Epicatechin is a flavan-3-ol,a type of natural phenol and antioxidant.It is a plant secondary metabolite.The name of the catechin chemical family derives from catechu,which is the tannic juice or boiled extract of Mimosa catechu (Acacia catechu L.f).	price>
R-R-4333	3-O-Methyldopa-d3 CAS No.586954-09-8	3-O-Methyldopa-d3/CAS No.586954-09-8 is deuterium labeled 3-O-Methyldopa. 3-O-Methyldopa is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits the pharmacodynamics of l-DOPA and dopamine.	price>
R-C-2634	Dequalinium Chloride CAS:522-51-0	Dequalinium chloride is a topical bacteriostat that is available as various salts.It is used in wound dressings and mouth infections and may also have antifungal action,but may cause skin ulceration.	price>
R-R-4334	UNC9995 CAS No.1354030-52-6	UNC9995/CAS No.1354030-52-6 is a β-arrestin2-biased agonist of dopamine receptor Drd2. UNC9995 inhibits NLRP3 inflammasome activation by enhancing β-arrestin2-NLRP3 interaction, thus prevents neuronal degeneration. Futhermore, UNC9995 activates the Drd2/β-arrestin2 signaling to prevent inflammation-related genes transcription-induced by JAK/STAT3. UNC9995 improves depressive behavior in mouse model, and improves astrocytes dysfunctions.	price>
R-C-2635	Pirfenidone CAS:53179-13-8	Pirfenidone(AMR69)is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells.Pirfenidone has growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines.Pirfenidone also has anti-inflammatory activities.	price>
R-R-4335	SKF 83822 CAS No.74115-08-5	SKF 83822/CAS No.74115-08-5 is an atypical agonist of dopamine D1 receptor. SKF 83822 activates adenylyl cyclase (AC), but not phospholipase C (PLC). SKF 83822 is also proved to stimulate AC via cAMP production. SKF 83822 can be used for research of schizophrenia.	price>
R-C-2636	A 77-01 CAS:607737-87-1	A 77-01 is a potent inhibitor of transforming growth factor(TGF)-β type I receptor superfamily activin-like kinase ALK5 with an IC50 of 25nM.	price>
R-R-4336	Rimcazole dihydrochloride CAS No.75859-03-9	Rimcazole (BW 234U) dihydrochloride/CAS No.75859-03-9 is a carbazole derivative that acts in part as a sigma (σ) receptor antagonist. Rimcazole dihydrochloride also binds with moderate affinity to the dopamine transporter and inhibit dopamine uptake. Rimcazole dihydrochloride can reduce locomotor activity and sensitization. Rimcazole dihydrochloride also can be used for the research of cancer.	price>
R-C-2637	Rottlerin CAS:82-08-6	Rottlerin is an angiogenesis inhibitor and an inhibitor of protein kinase Cdelta (PKCdelta)and calmodulin kinase III.Rottlerin induces cyclooxygenase-2 upregulation through an ATF4 and reactive oxygen species-independent pathway in HEI-OC1 cells.Rottlerin exerts its anti-tumor activity through inhibition of Skp2 in breast cancer cells.	price>
R-R-4337	SKF 83959 hydrobromide CAS No.67287-95-0	SKF83959 hydrobromide/CAS No.67287-95-0 is a potent and selective dopamine D1-like receptor partial agonist. SKF83959 hydrobromide Ki values for rat D1, D5, D2 and D3 receptors are 1.18, 7.56, 920 and 399 nM, respectively. SKF83959 hydrobromide is a potent allosteric modulator of sigma (σ)-1 receptor. SKF83959 hydrobromide belongs to benzazepine family and has improvements on cognitive dysfunction.	price>
R-C-2638	Bryostatin 1 CAS:83314-01-6	Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a potent and central nervous system(CNS)-permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain of Munc13-1 and the full-length Munc13-1 protein with Kis of 8.07nM and 0.45nM,respectively.	price>
R-R-4338	PF-06256142 CAS No.1609583-14-3	PF-06256142/CAS No.1609583-14-3 is a potent, selective, CNS-penetrant and orally active agonist of the D1 receptor, with an EC50 and Ki of 33 nM and 12 nM, respectively.	price>
R-C-2639	ZIP CAS:863987-12-6	ZIP is a selective peptide inhibitor of PKMζ.ZIP injections can block the impairment in morphine conditioned place preference induced.	price>
R-R-4339	Tavapadon CAS No.1643489-24-0	Tavapadon (PF-06649751)/CAS No.1643489-24-0 is an orally active and highly selective dopamine D1/D5 receptor partial agonist.	price>
R-C-2640	PPY A CAS:875634-01-8	PPY A is a potent inhibitor of T315l mutant and wild-type Abl kinases(IC50 values are 9 and 20nM,respectively).Inhibits growth of cells transformed with either the Bcr-Abl T315l mutant or wild-type Bcr-Abl gene.	price>

631632633634635636 637638639640641