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Catalog	name	Description	price
R-R-4287	MPTP hydrochloride CAS No.23007-85-4	MPTP hydrochloride/CAS No.23007-85-4 is a brain-penetrating dopamine neurotoxin, inducing Parkinson disease. MPTP hydrochloride, precursor of MPP+, induces apoptosis.	price>
R-R-4288	Oxidopamine hydrochloride CAS No.28094-15-7	Oxidopamine (6-OHDA) hydrochloride/CAS No.28094-15-7 is an antagonist of the neurotransmitter dopamine. Oxidopamine hydrochloride is a widely used neurotoxin and selectively destroys dopaminergic neurons. Oxidopamine hydrochloride promotes COX-2 activation, leading to PGE2 synthesis and pro-inflammatory cytokine IL-1β secretion.	price>
R-C-2589	Piperlongumine CAS:20069-09-4	Piperlongumine is a alkaloid,possesses ant-inflammatory,antibacterial, antiangiogenic,antioxidant,antitumor,and antidiabetic activities.Piperlongumine induces ROS,and induces apoptosis in cancer cell lines.Piperlongumine shows anti-cardiac fibrosis activity,suppresses myofibroblast transformation via suppression of the ERK1/2 signaling pathway.	price>
R-R-4289	SKF 81297 CAS No.71636-61-8	SKF 81297/CAS No.71636-61-8 is a potent and selective dopamine D1 receptor agonist.	price>
R-C-2590	mricasan (IDN-6556) CAS:254750-02-2	Emricasan(PF 03491390,IDN-6556)is an orally active and irreversible pan-caspase inhibitor.Emricasan inhibits Zika virus(ZIKV)-induced increases in caspase-3 activity and protected human cortical neural progenitors.	price>
R-R-4290	Fallypride CAS No.166173-78-0	Fallypride/CAS No.166173-78-0 is a potent antagonist of dopamine D2/D3 receptor. Fallypride, in the form of fallypride (18F), can be used as a positron emission tomography (PET) radiotracer.	price>
R-C-2591	GRI 977143 CAS:325850-81-5	GRI977143 is a selective lysophosphatidic acid 2(LPA2)receptor non-lipid agonist (EC50=3.3μM).GRI977143 does not activate other LPA GPCRs at concentrations up to 10μM.	price>
R-R-4291	Octoclothepin maleate salt CAS No.4789-68-8	Octoclothepin maleate salt/CAS No.4789-68-8, an orally active neuroleptic agent, is a dual SR-2A and D2DR inhibitor. Octoclothepin maleate salt reveals an intensive central depressant action in a series of observational and instrumental procedures in rodents.	price>
R-C-2592	AZ 10417808 CAS:331645-84-2	AZ 10417808 is a selective caspase-3 inhibitor with IC50 value of 14.9uM.AZ 10417808(AQZ-1)is a potent small molecule nonpeptidic inhibitor of caspase-3, which block cellular and biochemical features of apoptosis.	price>
R-R-4292	Clozapine N-oxide dihydrochloride CAS No.2250025-93-3	Clozapine N-oxide dihydrochloride/CAS No.2250025-93-3 is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide dihydrochloride activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide dihydrochloride can cross the blood-brain barrier. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist.	price>
R-C-2593	Muristerone A CAS:38778-30-2	Muristerone A is a phytoecdysteroid analog of ecdysone which induces genes in mammalian cells and causes apoptosis in cells transfected with wild-type Bax.	price>
R-R-4293	SKF 38393 hydrochloride CAS No.62717-42-4	SKF 38393 hydrochloride/CAS No.62717-42-4 is a selective agonist of the dopamine D1 receptor (D1DR) with an IC50 of 110 nM.	price>
R-C-2594	SJ 172550 CAS:431979-47-4	SJ 172550 is the first MDMX inhibitor with EC50 of 0.84uM;binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified.	price>
R-R-4294	Cabergoline CAS No.81409-90-7	Cabergoline/CAS No.81409-90-7 is an ergot derived-dopamine D2-like receptor agonist that has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respectively).	price>
R-C-2595	Betulinic acid CAS:472-15-1	Betulinic acid is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba,the common white birch)with antiinflammatory,anti-HIV and antineoplastic activities.Betulinic acid induces apoptosis through induction of changes in mitochondrial membrane potential, production of reactive oxygen species,and opening of mitochondrial permeability transition pores,resulting in the release of mitochondrial apogenic factors, activation of caspases,and DNA fragmentation.	price>
R-R-4295	Fluphenazine dihydrochloride CAS No.146-56-5	Fluphenazine dihydrochloride/CAS No.146-56-5 is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine dihydrochloride blocks neuronal voltage-gated sodium channels. Fluphenazine dihydrochloride acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine dihydrochloride can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine dihydrochloride can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2.	price>
R-C-2596	Plumbagin CAS:481-42-5	Plumbagin,exhibits cytotoxicity in rodent models of carcinogenesis and carcinoma;has antifungal,antiviral,and antibacterial action.	price>
R-R-4296	ONC206 CAS No.1638178-87-6	ONC206/CAS No.1638178-87-6 is an analogue of TRAIL inducer ONC201. ONC206 is a selective antagonist of the D2-like dopamine receptors (DRD2/3/4) at nanomolar concentrations. ONC206 has broad-spectrum anti-tumor activity.	price>
R-C-2597	HLI 373 CAS:502137-98-6	HLI 373 is an inhibitor of Hdm2 ubiquitin ligase(E3)which blocks Hdm2-mediated ubiquitylation,proteasomal degradation of p53 and activates p53-dependent transcription.	price>
R-R-4297	Sulpiride CAS No.15676-16-1	Sulpiride/CAS No.15676-16-1 is an orally active dopamine D2/D3 receptor antagonist. Sulpiride is an atypical antipsychotic agent of the benzamide family. Sulpiride can be used in research into anxiety, depression and breast cancer.	price>

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