Xi'an ruixi Biological Technology Co

Home > Keywords >

Catalog	name	Description	price
R-C-2484	AZ-628 CAS:878739-06-1	AZ-628 is a selective,orally available Raf inhibitor with excellent pharmacokinetic properties and robust tumor growth inhibition in xenograft studies((IC50 values are 29,34 and 105 nM for c-Raf1,B-RafV600E and wild-type B-Raf,respectively).AZ-628 inhibits growth,and induces cell cycle arrest and apoptosis in colon and melanoma cell lines with the B-RafV600E mutation.	price>
R-R-4184	BMS CCR2 22 CAS No.445479-97-0	BMS CCR2 22/CAS No.445479-97-0 is a potent, specific and high affinity CC-type chemokine receptor 2 (CCR2) antagonist with excellent binding affinity (binding IC50 of 5.1 nM) and potent functional antagonism (calcium flux IC50 of 18 nM and chemotaxis IC50 of 1 nM).	price>
R-C-2485	AZD-8330 CAS:869357-68-6	AZD8330(ARRY704 and ARRY424704)is an orally active,selective MEK inhibitor with potential antineoplastic activity.MEK inhibitor AZD8330 specifically inhibits mitogen-activated protein kinase kinase 1(MEK or MAP/ERK kinase1),resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation.	price>
R-R-4185	CCR2 antagonist 1 CAS No.1683534-96-4	CCR2 antagonist 1/CAS No.1683534-96-4 is a high-affinity and long-residence-time CCR2 antagonist, with a Ki of 2.4 nM.	price>
R-C-2486	EX-527 CAS:49843-98-3	Selisistat(EX-527)is a SirT1 inhibitor for treatment of Huntington is disease. EX-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism.Ex-527 is widely used as a major inhibitor of Sirtuin enzymes,which are a family of highly conserved protein deacetylases and have been linked with caloric restriction and aging by modulating energy metabolism,genomic stability, and stress resistance.	price>
R-R-4186	SB297006 CAS No.58816-69-6	SB297006/CAS No.58816-69-6 is a CCR3 antagonist, which significantly inhibits proliferation and neurosphere formation in CCL11-treated neural progenitor cells.	price>
R-C-2487	Cobicistat (GS-9350) CAS:1004316-88-4	Cobicistat is a potent and selective inhibitor of cytochrome P450 3A(CYP3A) enzymes with IC50s of 30-285nM.Cobicistat is a pharmacokinetic enhancer which increases the overall absorption of several HIV medications.	price>
R-R-4187	GSK2239633A CAS No.1240516-71-5	GSK2239633A/CAS No.1240516-71-5 is a CC-chemokine receptor 4 (CCR4) antagonist, which inhibits the binding of [125I]-TARC to human CCR4 with a pIC50 of 7.96 ± 0.11.	price>
R-C-2488	Apremilast CAS:608141-41-9	Apremilast(CC-10004)is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase(PDE-4)with an IC50 of 74nM.Apremilast inhibits TNF-α release by lipopolysaccharide(LPS)with an IC50 of 104nM.	price>
R-R-4188	LMD-009 CAS No.950195-51-4	LMD-009/CAS No.950195-51-4 is a selective CCR8 nonpeptide agonist. LMD-009 mediates chemotaxis, inositol phosphate accumulation, and calcium release in high potencies with EC50s from 11 to 87 nM.	price>
R-C-2489	BRL 54443 CAS:57477-39-1	BRL 54443 is a potent 5-HT1E/1F receptor agonist(Ki values are 1.1nM and 0.7 nM respectively);displays>30-fold selectivity over other 5-HT and dopamine receptors.	price>
R-R-4189	RS102895 CAS No.300815-41-2	RS102895/CAS No.300815-41-2 is a potent CCR2 antagonist, with an IC50 of 360 nM, and shows no effect on CCR1.	price>
R-C-2490	GW-9508 CAS: 885101-89-3	GW9508 is a potent and selective G protein-coupled receptors FFA1 (GPR40)and GPR120 agonist with pEC50s of 7.32 and 5.46,respectively.GW9508 shows ~100-fold selectivity for GPR40 over GPR120.GW9508 is inactive against other GPCRs,kinases,proteases,integrins and PPARs.GW9508 is a glucose-sensitive insulin secretagogue and an ATP-sensitive potassium(KATP)channels opener. Anti-inflammatory and anti-atherosclerotic activities.	price>
R-R-4190	CCR2-RA-[R] CAS No.512177-83-2	CCR2-RA-[R]/CAS No.512177-83-2 is an allosteric antagonist of the C-C chemokine receptor type 2 (CCR2) with an IC50 of 103 nM.	price>
R-C-2491	Gemcitabine elaidate（ CO-101,CP-4126） CAS:210829-30-4	Gemcitabine elaidate（CO-101 and CP-4126）is a lipophilic,unsaturated fatty acid ester derivative of gemcitabine (dFdC),an antimetabolite deoxynucleoside analogue,with potential antineoplastic activity.Upon hydrolysis intracellularly by esterases,the prodrug gemcitabine is converted into the active metabolites difluorodeoxycytidine di- and tri-phosphate(dFdCDP and dFdCTP)by deoxycytidine kinase.dFdCDP inhibits ribonucleotide reductase,thereby decreasing the deoxynucleotide pool available for DNA synthesis;dFdCTP is incorporated into DNA,resulting in DNA strand termination and apoptosis.	price>
R-R-4191	TAK-220 CAS No.333994-00-6	TAK-220/CAS No.333994-00-6 is a selective and orally bioavailable CCR5 antagonist, with IC50s of 3.5 nM and 1.4 nM for inhibition on the binding of RANTES and MIP-1α to CCR5, respectively, but shows no effect on the binding to CCR1, CCR2b, CCR3, CCR4, or CCR7; TAK-220 also selectively inhibits HIV-1, with EC50s of 1.2 nM (HIV-1 KK), 0.72 nM (HIV-1 CTV), 1.7 nM (HIV-1 HKW), 1.7 nM (HIV-1 HNK), 0.93 nM (HIV-1 HTN), and 0.55 nM (HIV-1 HHA), and EC90s of 12 nM (HIV-1 KK), 5 nM (HIV-1 CTV), 12 nM (HIV-1 HKW), 28 nM (HIV-1 HNK), 15 nM (HIV-1 HTN), and 4 nM (HIV-1 HHA) in PBMCs.	price>
R-R-4192	BI 639667 CAS No.1295298-26-8	BI 639667 (compound 19n)/CAS No.1295298-26-8, a third azaindazole series compound, is a CCR1 antagonist, with an IC50 of 1.8 nM in Ca2+ flux assay.	price>
R-C-2492	Indisulam (E 7070) CAS:165668-41-7	Indisulam(E 7070)is a carbonic anhydrase inhibitor with anticancer activity. Indisulam(E 7070)is a sulfonamide agent that targets the G1 phase of the cell cycle.Indisulam(E 7070)causes a blockade in the G1/S transition through inhibition of the activation of both CDK2 and cyclin E.Indisulam(E 7070)targets splicing by inducing RBM39 degradation via recruitment to DCAF15.	price>
R-C-2493	HSP-990 CAS:934343-74-5	NVP-HSP990 is a potent and selective Hsp90 inhibitor,with IC50 values of 0.6,0.8,and 8.5nM for Hsp90α,Hsp90β,and Grp94,respectively.	price>
R-R-4193	YM022 CAS No.145084-28-2	YM022/CAS No.145084-28-2 is a highly potent, selective and orally active gastrin/cholecystokinin (CCK)-B receptor (CCK-BR) antagonist. YM022 shows the Ki values of 68 pM and 63 nM for CCK-B and CCK-A receptor, respectively. YM022 can inhibit gastrin-induced gastric acid secretion and histidine decarboxylase activation in vivo.	price>

624625626627628629 630631632633634