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Catalog	name	Description	price
R-R-4246	CXCR7 antagonist-1 CAS No.1613021-99-0	CXCR7 antagonist-1/CAS No.1613021-99-0 is a CXCR7 antagonist that inhibits the binding of the SDF-1 chemokine (also known as the CXCL12 chemokine) or I-TAC (also known as CXCL11) to the chemokine receptor CXCR7. CXCR7 antagonist-1 is useful in preventing tumor cell proliferation, tumor formation, inflammatory diseases, and many other diseases (extracted from patent WO2014085490A1, compound 1.128).	price>
R-C-2547	NS11394 CAS:951650-22-9	NS-11394 is a drug which acts as a subtype-selective positive allosteric modulator at GABAA receptors,with selectivity for the α3 and α5 subtypes. NS11394 has a unique subtype-selective GABA(A)receptor profile and represents an excellent pharmacological tool to further understanding on the relative contributions of GABA(A)receptor subtypes in various therapeutic areas.	price>
R-R-4247	ML 145 CAS No.1164500-72-4	ML 145/CAS No.1164500-72-4 is a selective and competitive human GPR35/CXCR8 antagonist with an IC50/EC50 of 20.1 nM. ML 145 has over 1000-fold more selective for GPR35 compared to GPR55 (IC50/EC50=21.7 μM). ML 145 has no significant activity for GPR35 at either rodent ortholog.	price>
R-C-2548	TG6-10-1 CAS:1415716-58-3	TG6-10-1 is an EP2 antagonist,shows low-nanomolar antagonist activity against only EP2,>300-fold selectivity over human EP3,EP4,and IP receptors,100-fold selectivity over EP1 receptors.	price>
R-R-4248	NBI-74330 CAS No.855527-92-3	NBI-74330/CAS No.855527-92-3 is a potent antagonist for CXCR3, and exhibits potent inhibition of (125I)CXCL10 and (125I)CXCL11 specific binding with Ki of 1.5 and 3.2 nM, respectively.	price>
R-C-2549	Elacridar HCl CAS:143851-98-3	Elacridar(GF120918A)is a P-glycoprotein(P-gp)inhibitor,and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein(Pgp)to investigate the role of transporters in the disposition of various test molecules.In vitro, GF120918A demonstrated high plasma protein binding across species,although a definitive protein binding evaluation was precluded by poor recovery, particularly in buffer and in mouse,rat,and dog plasma.GF120918A did not demonstrate potent inhibition of several human cytochrome P450 enzymes evaluated in vitro,with IC(50)values well above concentrations anticipated to be achieved in vivo.Together,these data confirm the utility of GF120918A as a tool P-glycoprotein inhibitor in preclinical species and offer additional guidance on preclinical dose regimens likely to produce P-glycoprotein-mediated effects.	price>
R-R-4249	VUF11207 fumarate CAS No.1785665-61-3	VUF11207 fumarate/CAS No.1785665-61-3 is a CXCR7 agonist that binds specifically to CXCR7. VUF11207 fumarate reduces CXCL12-mediated osteoclastogenesis and bone resorption by inhibiting ERK phosphorylation.	price>
R-C-2550	Muscimol HBr CAS:18174-72-6	Muscimol hydrobromide is a potent but toxic structural analog of g-aminobutyric acid(GABA),with a zwitterionic structure.	price>
R-R-4250	IT1t dihydrochloride CAS No.1092776-63-0	IT1t dihydrochloride/CAS No.1092776-63-0 is a potent CXCR4 antagonist; inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM.	price>
R-C-2551	Epirubicin hydrochloride CAS:56390-09-1	Epirubicin is a cell-permeable anthracycline antitumor antibiotic.It is a stereoisomer(4-epi-isomer)of doxorubicin that exhibits reduced cardiotoxicity.It is used to inhibit topoisomerase II and DNA helicase activity.	price>
R-R-4251	PS372424 hydrochloride CAS No.1596362-29-6	PS372424 hydrochloride/CAS No.1596362-29-6, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity. PS372424 hydrochloride prevents human T-cell migration in a humanized model of arthritic inflammation.	price>
R-C-2552	AZD7762 CAS:860352-01-8	AZD-7762 is a synthetic small molecule inhibitor of checkpoint kinases(Chks)with potential chemosensitizing activity.AZD7762 binds to and inhibits Chks,which may prevent cell cycle arrest and subsequent nucleotide excision repair in DNA-damaged tumor cells,resulting in tumor cell apoptosis.This agent may enhance the cytotoxicity of DNA-damaging agents.Chks are protein kinases that regulate either G1/S or G2/M transitions in the cell cycle. In the presence of DNA damage or incomplete DNA replication,Chks become activated and initiate cell cycle arrest to allow DNA repair or the completion of DNA replication.	price>
R-R-4252	Reparixin L-lysine salt CAS No.266359-93-7	Reparixin L-lysine salt/CAS No.266359-93-7 is an allosteric inhibitor of chemokine receptor 1/2 (CXCR1/2) activation.	price>
R-C-2553	RO3280 CAS:1062243-51-9	Ro3280 is a selective inhibitor of PLK1 with IC50 value of 3nM.Polo-like kinase 1 (PLK1)is an enzyme and plays an important role in regulating cell cycles as an early trigger for G2/M phase transition.	price>
R-R-4253	TC14012 CAS No.368874-34-4	TC14012/CAS No.368874-34-4, a serum-stable derivative of T140, is a selective and peptidomimetic CXCR4 antagonist with an IC50 of 19.3 nM. TC14012 is a potent CXCR7 agonist with an EC50 of 350 nM for recruiting β-arrestin 2 to CXCR7. TC14012 has anti-HIV activity and anti-cancer activity.	price>
R-C-2554	BI 2536 CAS:755038-02-9	BI-2563 is a small molecule compound with potential antineoplastic activities.BI 2536 binds to and inhibits Polo-like kinase 1(Plk1),resulting in mitotic arrest,disruption of cytokinesis,and apoptosis in susceptible tumor cell populations.Plk1,a serine/threonine-protein kinase,is a key regulator of multiple processes fundamental to mitosis and cell division.	price>
R-R-4254	Kynurenic acid-d5 CAS No.350820-13-2	Kynurenic acid-d5/CAS No.350820-13-2 is the deuterium labeled Kynurenic acid. Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8.	price>
R-C-2555	BPR1J-097 CAS:1327167-19-0	BPR1J-097 is a novel small molecule FLT-3 inhibitor with promising in vivo anti-tumour activities.BPR1J-097 inhibited FLT3/signal transducer and activator of transcription 5 phosphorylation and triggered apoptosis in FLT3-driven AML cells.BPR1J-097 also showed favourable pharmacokinetic property and pronounced dose-dependent tumour growth inhibition and regression in FLT3-driven AML murine xenograft models.	price>
R-R-4255	Kynurenic acid sodium CAS No.2439-02-3	Kynurenic acid sodium/CAS No.2439-02-3, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid sodium is also an agonist of GPR35/CXCR8.	price>
R-C-2556	Dynasore CAS:304448-55-3	Dynasore is a cell-permeable,reversible non-competitive dynamin inhibitor of GTPase activity of dynamin 1/2,with IC50 of 15μM in a cell-free assay,also inhibits the mitochondrial dynamin Drp1,with no effect against other small GTPase.Dynasore suppresses mTORC1 activity and induces autophagy.	price>

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