Xi'an ruixi Biological Technology Co

Home > Keywords >

Catalog	name	Description	price
R-C-2524	SB705498 CAS：501951-42-4	SB-705498 is a potent,selective and orally bioavailable transient receptor potential vanilloid 1(TRPV1)receptor antagonist with a pIC50 of 7.1.	price>
R-R-4224	Proglumide sodium CAS No.99247-33-3	Proglumide sodium/CAS No.99247-33-3 is a nonpeptide and orally active cholecystokinin (CCK)-A/B receptors antagonist. Proglumide sodium has ability to inhibit gastric secretion and to protect the gastroduodenal mucosa. Proglumide sodium also has antiepileptic and antioxidant activities.	price>
R-C-2525	GlyH101 CAS：328541-79-3	GlyH-101 is a CFTR inhibitor(cystic fibrosis transmembrane conductance regulator).GlyH-101 is a glycine hydrazide that has been shown to block CFTR channels.GlyH-101 blocks the open pore of cardiac CFTR channels at an electrical distance of 0.15 Â±0.03 from the external membrane surface.	price>
R-R-4225	Proglumide CAS No.6620-60-6	Proglumide/CAS No.6620-60-6 is a nonpeptide and orally active cholecystokinin (CCK)-A/B receptors antagonist. Proglumide selective blocks CCK’s effects in the central nervous system (CNS). Proglumide has ability to inhibit gastric secretion and to protect the gastroduodenal mucosa. Proglumide also has antiepileptic and antioxidant activities.	price>
R-C-2526	Ataluren (PTC124) CAS：775304-57-9	Ataluren(PTC124)selectively induces ribosomal read-through of premature but not normal termination codons,with EC50 of 0.1μM in HEK293 cells,may provide treatment for genetic disorders caused by nonsense mutations.	price>
R-R-4226	SR 146131 CAS No.221671-61-0	SR 146131/CAS No.221671-61-0 is a potent, orally available, and selective nonpeptide (cholecystokinin 1) receptor agonist.	price>
R-C-2527	Vinpocetine CAS：42971-09-5	Vinpocetine(Ethyl apovincaminate)is a derivative of the alkaloid Vincamine that blocks voltage-gated Na+ channels.The IC50 value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17μM.Vinpocetine is a phosphodiesterase(PDE)inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex(IKK).	price>
R-R-4227	A71623 CAS No.130408-77-4	A71623/CAS No.130408-77-4, a CCK-4-based peptide, is a potent and highly selective CCK-A full agonist. The IC50s for A-71623 are 3.7 nM in guinea pig pancreas (CCK-A) and 4500 nM in cerebral cortex (CCK-B) in radioligand binding assays, respectively.	price>
R-C-2528	Losartan potassium CAS：124750-99-8	Losartan potassium(DuP-753 potassium)is an angiotensin II receptor type 1 (AT1)antagonist,competing with the binding of angiotensin II to AT1 with an IC50 of 20nM.	price>
R-R-4228	Lorglumide sodium salt CAS No.1021868-76-7	Lorglumide sodium salt (CR-1409 sodium salt)/CAS No.1021868-76-7 is a potent cholecystokinin (CCK) receptor antagonist.	price>
R-C-2529	Apalutamide (ARN-509) CAS：956104-40-8	Apalutamide(ARN-509 and JNJ-56021927)is an androgen receptor antagonist with potential antineoplastic activity.ARN-509 binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus.This prevents binding to and transcription of AR-responsive genes.This ultimately inhibits the expression of genes that regulate prostate cancer cell proliferation and may lead to an inhibition of cell growth in AR-expressing tumor cells.	price>
R-R-4229	Lintitript CAS No.136381-85-6	Lintitript (SR 27897)/CAS No.136381-85-6 is a highly potent, selective, orally active, competitive and non-peptide cholecystokinin (CCK1) receptor antagonist with an EC50 of 6 nM and a Ki of 0.2 nM. Lintitript displays > 33-fold selectivity more selective for CCK1 than CCK2 receptors (EC50 value of 200 nM). Lintitript increases plasma concentration of leptin and food intake as well as plasma concentration of insulin.	price>
R-C-2530	Exemestane (FCE 24304) CAS：107868-30-4	Exemestane is a synthetic androgen analogue.Exemestane binds irreversibly to and inhibits the enzyme aromatase,thereby blocking the conversion of cholesterol to pregnenolone and the peripheral aromatization of androgenic precursors into estrogens.	price>
R-R-4230	Dexloxiglumide CAS No.119817-90-2	Dexloxiglumide/CAS No.119817-90-2 is a selective cholecystokinin type A (CCKA) receptor antagonist. Dexloxiglumide, the active enantiomer of Loxiglumide, inhibits smooth muscle cell contractions induced by cholecystokinin-octapeptide (CCK-8).	price>
R-C-2531	Fluticasone propionate CAS：80474-14-2	Fluticasone propionate,a potent topical anti-inflammatory corticosteroid,is a selective glucocorticoid receptor agonist,with an absolute affinity(KD)of 0.5 nM.Fluticasone propionate shows little or no activity at other steroid receptors.Anti-viral activity.	price>
R-R-4231	CCK-B Receptor Antagonist 2 CAS No.155412-88-7	CCK-B Receptor Antagonist 2/CAS No.155412-88-7, compound 15b, is a potent and orally active Gastrin/CCK-B antagonist with an IC50 value of 0.43 nM. CCK-B Receptor Antagonist 2 also inhibits gastrin/CCK-A activity with an IC50 of 1.82 μM.	price>
R-C-2532	APD668 CAS：832714-46-2	APD668 is a potent,selective and orally active agonist of G-protein coupled receptor GPR119,with EC50s of 2.7nM and 33nM for hGPR119 and rGPR119, respectively.APD668 shows no significant inhibition of any of the five major CYP isoforms with the exception of CYP2C9(Ki=0.1μM).APD668 can be used for the research of steatohepatitis and diabetes.	price>
R-R-4232	L-365260 hemihydrate	L-365260 hemihydrate is an orally active and selective antagonist of non-peptide gastrin and brain cholecystokinin receptor (CCK-B), with Kis of 1.9 nM and 2.0 nM, respectively. L-365260 hemihydrate interacts in a stereoselective and competitive manner with guinea pig stomach gastrin and brain CCK receptors.	price>
R-C-2533	Canagliflozin (JNJ 28431754) CAS：842133-18-0	Canagliflozin(JNJ 28431754)is a selective SGLT2 inhibitor with IC50s of 2nM, 3.7nM,and 4.4nM for mSGLT2,rSGLT2,and hSGLT2 in CHOK cells,respectively.	price>
R-R-4233	(Rac)-Sograzepide CAS No.168161-71-5	(Rac)-Sograzepide/CAS No.168161-71-5 is an antagonist of cholecystokinin B (CCK-B) receptor, and has the potential of reducing the secretion of gastric acid.	price>

621622623624625626 627628629630631