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Catalog	name	Description	price
R-C-2514	Olprinone CAS:106730-54-5	Olprinone(Loprinone)is a potent phosphodiesterase(PDE)3 inhibitor,with IC50s of 150,100,0.35 and 14μM for PDE1,PDE2,PDE3 and PDE4,respectively.Olprinone is used for the research of heart failure due to its positive inotropic and vasodilative effects.Anti-inflammatory activity.	price>
R-R-4214	CCR4-351 hydrochloride CAS No.2174938-71-5	CCR4-351 hydrochloride/CAS No.2174938-71-5 is an orally active, potent and selective CCR4 antagonist. CCR4-351 hydrochloride, featuring a novel piperidinyl-azetidine motif, has IC50s of 22 nM and 50 nM in the calcium flux and CTX assay. CCR4-351 hydrochloride has antitumor activity.	price>
R-C-2515	Gimeracil CAS:103766-25-2	Gimeracil is a pyridine derivative with antitumor activity.Gimeracil enhances the antitumor activity of fluoropyrimidines by competitively and reversibly inhibiting the enzyme dihydropyrimidine dehydrogenase causing decreased degradation of the fluoropyrimidines.	price>
R-R-4215	INCB3344 R-isomer	INCB3344 R-isomer is the R-isomer of INCB3344. INCB3344 is a potent, selective and orally bioavailable CCR2 antagonist with IC50 values of 5.1 nM (hCCR2) and 9.5 nM (mCCR2) in binding antagonism and 3.8 nM (hCCR2) and 7.8 nM (mCCR2) in antagonism of chemotaxis activity.	price>
R-C-2516	Tadalafil CAS:171596-29-5	Tadalafil（IC351）is PDE5 inhibitor marketed in pill form for treating erectile dysfunction(ED)under the name Cialis,and under the name Adcirca for the treatment of pulmonary arterial hypertension.	price>
R-R-4216	BMS-817399 CAS No.1202400-18-7	BMS-817399/CAS No.1202400-18-7 is a potent, selective, and orally bioavailable CCR1 antagonist. BMS-817399 exhibits CCR1 binding affinity and chemotaxis inhibition potencies of 1 and 6 nM (IC50), respectively. BMS-817399 can be used for the research of rheumatoid arthritis.	price>
R-C-2517	NSC14613(PluriSln1) CAS:91396-88-2	PluriSln-1(NSC 14613)is pluripotent cell-specific inhibitor(PluriSIn).PluriSIn #1 induces ER stress,protein synthesis attenuation,and apoptosis in hPSCs. PluriSIn #1 was also cytotoxic to mouse blastocysts,indicating that the dependence on oleate is inherent to the pluripotent state.The use of human pluripotent stem cells(hPSCs)in cell therapy is hindered by the tumorigenic risk from residual undifferentiated cells.	price>
R-R-4217	CCR3 antagonist 1 CAS No.879399-82-3	CCR3 antagonist 1/CAS No.879399-82-3 is a potent antagonist of CCR3, used for the research of immunologic and inflammatory diseases.	price>
R-C-2518	AGI-6780 CAS:1432660-47-3	AGI-6780 is a potent and selective IDH2 inhibitor.AGI-6780 inhibits the tumor-associated mutant IDH2/R140Q.Treatment with AGI-6780 induced differentiation of TF-1 erythroleukemia and primary human acute myelogenous leukemia cells in vitro.	price>
R-R-4218	Maraviroc-d6 CAS No.1033699-22-7	Maraviroc-d6 (UK-427857-d6)/CAS No.1033699-22-7 is the deuterium labeled Maraviroc. Maraviroc (UK-427857) is a selective CCR5 antagonist with activity against human HIV.	price>
R-C-2519	Dimethyloxaloylglycine;DMOG CAS:89464-63-1	DMOG(Dimethyloxallyl Glycine)is a cell permeable and competitive inhibitor of HIF-PH,which results in HIF-1α stabilisation and accmulation in vitro and in vivo.DMOG is an α-ketoglutarate analogue and inhibits α-KG-dependent hydroxylases.DMOG acts as a pro-angiogenic agent and plays a protective role in experimental model of colitis and diarrhoea via HIF-1 related signal.DMOG induces cell autophagy.	price>
R-R-4219	CKLF1-C27 CAS No.891861-48-6	CKLF1-C27/CAS No.891861-48-6, a C-terminal peptide of CKLF1, binds to CCR4 receptor and activates ERK1/2 pathway. CKLF1-C27 can abrogate the effect of CKLF1 on cells by competing for CCR4 receptor. CKLF1-C27 shows great effect on promoting proliferation on HUVECs. CKLF1-C27 has the potential for psoriasis research.	price>
R-C-2520	Moclobemide CAS:71320-77-9	Moclobemide(Ro111163)is a brain-penetrant and reversible monoamine oxidase(MAO-A)inhibitor with an IC50 of 6.061μM for hMAO-A.Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice.	price>
R-R-4220	α-NETA CAS No.115066-04-1	α-NETA/CAS No.115066-04-1 is a potent and noncompetitive choline acetyltransferase (ChA) inhibitor with an IC50 of 9 μM. α-NETA is a potent ALDH1A1 (IC50=0.04 µM) and chemokine-like receptor-1 (CMKLR1) antagonist. α-NETA weakly inhibits cholinesterase (ChE; IC50=84 µM) and acetylcholinesterase (AChE; IC50=300 µM). α-NETA has anti-cancer activity.	price>
R-C-2521	Rosiglitazone CAS:155141-29-0	Rosiglitazone maleate(BRL 49653),a member of the thiazolidinedione class of antihyperglycaemic agents,is a high-affinity selective agonist of the peroxisome proliferator-activated receptor-γ(PPAR-γ)with IC50 of 42nM.	price>
R-R-4221	Devazepide CAS No.103420-77-5	Devazepide (L-364,718)/CAS No.103420-77-5 is a potent, competitive, selective and orally active nonpeptide antagonist of cholecystokinin (CCK) receptor, with IC50s of 81 pM, 45 pM and 245 nM for rat pancreatic, bovine gallbladder and guinea pig brain CCK receptors, respectively. Devazepide (L-364,718) is effective for gastrointestinal disorders.	price>
R-C-2522	PF3845 CAS:1196109-52-0	PF-3845 is a fatty acid amide hydrolase(FAAH)inhibitor,and acts in the nervous system to reverse LPS-induced tactile allodynia in mice.PF-3845 promotes neuronal survival,attenuates inflammation and improves functional recovery in mice with traumatic brain injury.	price>
R-R-4222	Sograzepide CAS No.155488-25-8	Sograzepide (Netazepide; YF 476; YM-220)/CAS No.155488-25-8 is an extremely potent , highly selective and orally active Gastrin/CCK-B antagonist with an IC50 value of 0.1 nM, has inhibitory effect on Gastrin/CCK-A activity with an IC50 of 502 nM. Sograzepide (Netazepide; YF 476; YM-220) replaces the specific binding of [125I]CCK-8 to the rat brain, cloned canine and cloned human Gastrin/CCK-B receptors, with Ki values of 0.068, 0.62 and 0.19 nM, respectively.	price>
R-C-2523	Tezacaftor (VX-661) CAS:1152311-62-0	Tezacaftor（VX-661）is CFTR modulator.VX-661 is potentially useful for treatment of cystic fibrosis disease.Cystic fibrosis(CF)is a genetic disease caused by defects in the CF transmembrane regulator(CFTR)gene,which encodes an epithelial chloride channel.	price>
R-R-4223	L-365260 CAS No.118101-09-0	L-365260/CAS No.118101-09-0 is an orally active and selective antagonist of non-peptide gastrin and brain cholecystokinin receptor (CCK-B), with Kis of 1.9 nM and 2.0 nM, respectively. L-365260 interacts in a stereoselective and competitive manner with guinea pig stomach gastrin and brain CCK receptors. L-365260 can enhance Morphine analgesia and prevents Morphine tolerance.	price>

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