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Catalog	name	Description	price
R-R-4202	IPG7236 CAS No.2756350-91-9	IPG7236/CAS No.2756350-91-9 is a selective CCR8 antagonist. IPG7236 exhibits significant tumor suppression in a mouse xenograft model of human breast cancer. IPG7236 can be used in cancer research.	price>
R-R-4203	MLN3126 CAS No.628300-71-0	MLN3126/CAS No.628300-71-0 is an orally active and potent CCR9 antagonist. MLN3126 inhibits CCL25-induced calcium mobilization and chemotaxis of mouse primary thymocytes, wiht an IC50 value of 6.3 nM for calcium influx.	price>
R-C-2504	Ixazomib citrate (MLN9708) CAS：1239908-20-3	Ixazomib citrate(MLN9708)is a reversible inhibitor of the chymotrypsin-like proteolytic β5 site of the 20S proteasome with an IC50 of 3.4nM and a Ki of 0.93nM.	price>
R-R-4204	CKLF1-C19 CAS No.960358-79-6	CKLF1-C19/CAS No.960358-79-6 is the C-terminal peptide of human chemokine-like factor 1 (CKLF1). CKLF1-C19 interacts with CCR4, and inhibits chemotaxis induced by both CKLF1 and CCL17. CKLF1-C19 can suppress allergic lung inflammation via inhibiting chemotaxis mediated by CCR3 and CCR4.	price>
R-C-2505	PR171(Carfilzomib) CAS:868540-17-4	Carfilzomib(PR-171)is an irreversible proteasome inhibitor with an IC50 of 5 nM in ANBL-6 and RPMI 8226 cells.	price>
R-R-4205	C-021 dihydrochloride CAS No.1784252-84-1	C-021 dihydrochloride/CAS No.1784252-84-1 is a potent CC chemokine receptor-4 (CCR4) antagonist. C-021 dihydrochloride potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM, respectively. C-021 dihydrochloride effectively prevents human CCL22-derived [35S]GTPγS from binding to the receptor with an IC50 of 18 nM.	price>
R-C-2506	LY411575 CAS:209984-57-6	LY-411575 is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082nM (membrane/cell-based),and also inhibits Notch S3 cleavage with IC50 of 0.39nM.	price>
R-R-4206	Vercirnon sodium CAS No.886214-18-2	Vercirnon (GSK1605786A) sodium/CAS No.886214-18-2 is an orally bioavailable, selective, and potent antagonist of CCR9. Vercirnon sodium inhibits CCR9-mediated Ca2+ mobilization and chemotaxis on Molt-4 cells with IC50 values of 5.4 and 3.4 nM, respectively. Vercirnon sodium is selective for CCR9 over CCR1-12 and CX3CR1-7 (IC50s>10 µM for all). Vercirnon sodium is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9 (CCR9A and CCR9B) with IC50 values of 2.8 and 2.6 nM, respectively.	price>
R-R-4207	CCR4 antagonist 4 CAS No.668980-17-4	CCR4 antagonist 4 (compound 22)/CAS No.668980-17-4 is a selective and potent antagonist of the CC chemokine receptor-4 (CCR4), with an IC50 of 0.02 μM. CCR4 antagonist 4 also blocks MDC-mediated chemotaxis (IC50: 0.007 μM) and Ca2+ mobilization (IC50: 0.003 μM). CCR4 antagonist 4 can be used for allergic inflammation research.	price>
R-C-2508	PF-5274857 CAS:1373615-35-0	PF-5274857 is a potent,selective,orally active and brain-penetrant antagonist of Smo,with an IC50 of 5.8nM and Ki of 4.6nM. PF-5274857 has potential for research of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway.	price>
R-R-4208	Nifeviroc CAS No.934740-33-7	Nifeviroc/CAS No.934740-33-7 is an orally active CCR5 antagonist. Nifeviroc is used for the study of HIV type-1 infection.	price>
R-C-2509	Bikinin(Abrasin) CAS:188011-69-0	Bikinin is a non-steroidal,ATP-competitive inhibitor of plant GSK-3/Shaggy-like kinases and activates BR(brassinosteroids)signaling.	price>
R-R-4209	CCR2 antagonist 4 CAS No.226226-39-7	CCR2 antagonist 4 (Teijin compound 1)/CAS No.226226-39-7 is a potent and specific CCR2 antagonist, with IC50s of 180 nM for CCR2b. CCR2 antagonist 4 potently inhibits MCP-1-induced chemotaxis with an IC50 of 24 nM.	price>
R-C-2510	AKT inhibitor IV CAS:959841-49-7	AKT Inhibitor IV promotes hyperphosphorylation of Akt(Protein kinase B), decreases phosphorylation of Akt substrates,and inhibits FOXO1a nuclear export (IC50=625nM in PTEN-null cells).AKT Inhibitor IV inhibits the proliferation of several cells lines(IC50 values are <1.25μM,320-670nM and 340nM for 786-O, HeLa and Jurkat cells,respectively).This compound also displays broad antiviral activity against negative-stranded RNA viruses.	price>
R-R-4210	Aplaviroc hydrochloride CAS No.461023-63-2	Aplaviroc (AK 602) hydrochloride/CAS No.461023-63-2, a SDP derivative, is a CCR5 antagonist, with IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.	price>
R-C-2511	MDL28170 CAS:88191-84-8	MDL-28170(Calpain Inhibitor III)is a potent and selective calpain inhibitor of calpain that penetrates the blood-brain barrier and inhibits brain cysteine protease activity after systemic administration.MDL-28170 is also an inhibitor of γ-secretase.	price>
R-R-4211	AZD-1678 CAS No.942137-41-9	AZD-1678/CAS No.942137-41-9 is a potent CCR4 receptor antagonist, with a pIC50 of 8.6.	price>
R-C-2512	LCZ696(Sacubitril;Valsartan) CAS:936623-90-4	Sacubitril/Valsartan(LCZ696),comprised Valsartan and Sacubitril(AHU377)in 1:1 molar ratio,is a first-in-class,orally bioavailable,and dual-acting angiotensin receptor-neprilysin(ARN)inhibitor for hypertension and heart failure. Sacubitril/Valsartan ameliorates diabetic cardiomyopathy by inhibiting inflammation,oxidative stress and apoptosis.	price>
R-R-4212	CCR4 antagonist 3 CAS No.1957-01-3	CCR4 antagonist 3/CAS No.1957-01-3 is a potent chemokine receptor 4 (CCR4) antagonist with an IC50 value of 1.7 μM for [125I]TARC (thymus and activation regulated chemokine). CCR4 antagonist 3 inhibits binding of radiolabeled TARC and macrophage-derived chemokine (MDC) to CCR4 receptors on the surface of CEM cells. CCR4 antagonist 3 also inhibits the in vitro migration of CEM cells mediated by TARC (IC50 = 6.4 μM).	price>
R-R-4213	CCX354 CAS No.1010073-75-2	CCX354/CAS No.1010073-75-2 is an antagonist of CCR1, with anti-inflammatory activity.	price>

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