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Catalog	name	Description	price
R-C-2492	Indisulam (E 7070) CAS:165668-41-7	Indisulam(E 7070)is a carbonic anhydrase inhibitor with anticancer activity. Indisulam(E 7070)is a sulfonamide agent that targets the G1 phase of the cell cycle.Indisulam(E 7070)causes a blockade in the G1/S transition through inhibition of the activation of both CDK2 and cyclin E.Indisulam(E 7070)targets splicing by inducing RBM39 degradation via recruitment to DCAF15.	price>
R-C-2493	HSP-990 CAS:934343-74-5	NVP-HSP990 is a potent and selective Hsp90 inhibitor,with IC50 values of 0.6,0.8,and 8.5nM for Hsp90α,Hsp90β,and Grp94,respectively.	price>
R-R-4193	YM022 CAS No.145084-28-2	YM022/CAS No.145084-28-2 is a highly potent, selective and orally active gastrin/cholecystokinin (CCK)-B receptor (CCK-BR) antagonist. YM022 shows the Ki values of 68 pM and 63 nM for CCK-B and CCK-A receptor, respectively. YM022 can inhibit gastrin-induced gastric acid secretion and histidine decarboxylase activation in vivo.	price>
R-C-2494	PTZ-343 CAS:101199-38-6	PTZ-343 is a potent enhancer of Luminol(HY-15922).PTZ-343 greatly increases the light output of the peroxidase-catalyzed luminol chemiluminescent oxidation reaction(>80%).	price>
R-R-4194	CCR8 antagonist 1 CAS No.723304-76-5	CCR8 antagonist 1 (compound 15)/CAS No.723304-76-5 is a potente human CCR8 antagonist with a Ki of 1.6 nM.	price>
R-C-2495	Golotimod CAS ：229305-39-9	Golotimod (SCV-07),an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy,stimulates thymic and splenic cell proliferation,and improves macrophage function.Golotimod(SCV-07)inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin.	price>
R-R-4195	Vicriviroc maleate CAS No.599179-03-0	Vicriviroc maleate (SCH-417690 maleate; SCH-D maleate)/CAS No.599179-03-0 is a potent, selective, oral bioavailable and CNS penetrated antagonist of CCR5, with a Ki of 2.5 nM, and also inhibits HIV-1 in PBMC cells, with IC90s of 3.3 nM (JrFL), 2.8 nM (ADA-M), 1.8 nM (301657), 4.9 nM (JV1083) and 10 nM (RU 570).	price>
R-C-2496	Uramustine CAS：66-75-1	Uramustine(INN）uracil mustard is a chemotherapy drug which belongs to the class of alkylating agents.It is used in lymphatic malignancies such as non-Hodgkin is lymphoma.It works by damaging DNA,primarily in cancer cells that preferentially take up the uracil due to their need to make nucleic acids during their rapid cycles of cell division.The DNA damage leads to apoptosis of the affected cells.Bone marrow suppression and nausea are the main side effects. Chemically it is a derivative of nitrogen mustard and uracil.	price>
R-R-4196	CCR1 antagonist 9 CAS No.1220026-26-5	CCR1 antagonist 9/CAS No.1220026-26-5 is a potent and selective CCR1 antagonist with an IC50 of 6.8 nM in calcium flux assay.	price>
R-C-2497	UNC-0638 CAS：1255580-76-7	UNC0638 selectively inhibits G9a and GLP histone methyltransferase activity with IC50s of less than 15nM and 19nM,respectively.UNC0638 has anti-FMDV(foot-and-mouth disease virus)and anti-VSV(vesicular stomatitis virus)activities.	price>
R-R-4197	AZD-4818 CAS No.1003566-93-5	AZD-4818/CAS No.1003566-93-5 is a potent antagonist of chemokine CCR1. AZD-4818 can be used for researching chronic obstructive pulmonary disease (COPD) .	price>
R-C-2498	Belnacasan (VX-765) CAS：273404-37-8	Belnacasan(VX-765)is an orally bioactive prodrug of VRT-043198,which is a potent and selective inhibitor of IL-converting enzyme(ICE)/caspase-1 with Kis of 0.8nM and less than 0.6nM for caspase-1 and caspase-4,respectively.Belnacasan (VX-765)inhibits the release of LPS-induced IL-1β and IL-18 by human PBMCs with an IC50 of ~0.7μM.	price>
R-R-4198	AZD2423 CAS No.1229603-37-5	AZD2423/CAS No.1229603-37-5 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator. AZD2423 has an IC50 of 1.2 nM for CCR2 Ca2+ flux .	price>
R-C-2499	Varlitinib (ARRY334543) CAS：845272-21-1	Varlitinib(ASLAN001)is a potent,reversible,small molecule pan-EGFR inhibitor with IC50s of 7,2,4nM for HER1,HER2 and HER4,respectively.	price>
R-R-4199	CCR4-351 CAS No.2174938-70-4	CCR4-351/CAS No.2174938-70-4 is an orally active, potent and selective CCR4 antagonist. CCR4-351, featuring a novel piperidinyl-azetidine motif, has IC50s of 22 nM and 50 nM in the calcium flux and CTX assay. CCR4-351 has antitumor activity.	price>
R-C-2500	AZD9056 hydrochloride CAS ：345303-91-5	AZD9056 hydrochloride is a selective orally active inhibitor of P2X7 which plays a significant role in inflammation and pain-causing diseases.	price>
R-R-4200	AZD-5672 CAS No.780750-65-4	AZD-5672/CAS No.780750-65-4 is an orally active, potent, and selective CCR5 antagonist (IC50=0.32 nM). AZD-5672 shows moderate activity against the hERG ion channel (binding IC50=7.3 μM). AZD5672 is a substrate of human P-gp, and inhibits P-gp-mediated digoxin transport (IC50=32 μM). AZD-5672 can be used for the research of rheumatoid arthritis.	price>
R-C-2501	SAR-020106 CAS：1184843-57-9	SAR-020106 is an ATP-competitive,potent,and selective CHK1 inhibitor with an IC50 of 13.3nM for human CHK1.SAR-020106 shows excellent selectivity over CHK2.SAR-020106 significantly enhances the cell killing of Gemcitabine and SN38 by 3-to 29-fold in several colon tumor lines and in a p53-dependent fashion.SAR-020106 can enhance antitumor activity with selected anticancer drugs.	price>
R-R-4201	CCR8 antagonist 2 CAS No.2756350-98-6	CCR8 antagonist 2/CAS No.2756350-98-6 is a potent antagonist of CCR8. CCR8 (C-C Motif Chemokine Receptor 8) is predominantly expressed on Treg cells and Th2 cells, but not on Th1 cells. CCR8 antagonist 2 inhibits CCR8 activity, which may be used in the research of diseases mediated by CCR8, such as cancer, and/or neuropathic pain (extracted from patent WO2022000443A1, compound 220).	price>
R-C-2502	BMS 986158 CAS：1800340-40-2	BMS-986158 is a potent BET inhibitor with IC50s of 6.6 and 5nM in NCI-H211 small cell lung cancer(SCLC)cells and MDA-MB231 triple negative breast cancer(TNBC)cells,respectively.	price>

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