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Catalog	name	Description	price
R-R-3991	Valsartan CAS No.137862-53-4	Valsartan (CGP 48933)/CAS No.137862-53-4 is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research.	price>
R-C-2292	Mezigdomide (CC-92480) CAS:2259648-80-9	CC-92480,a cereblon E3 ubiquitin ligase modulating drug(CELMoD),acts as a molecular glue.CC-92480 shows high affinity to cereblon,resulting in potent antimyeloma activity.	price>
R-R-3992	Talfirastide CAS No.51833-78-4	Angiotensin 1-7 (Ang-(1-7))/CAS No.51833-78-4 is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity .	price>
R-C-2293	Thalidomide-O-COOH (Cereblon ligand 3) CAS:1061605-21-7	Thalidomide-O-COOH(Cereblon ligand 3,E3 ligase Ligand 3),a Thalidomide-based Cereblon(CRBN)ligand,is used in the recruitment of CRBN protein. Thalidomide-O-COOH(Cereblon ligand 3)can be connected to the ligand for protein by a linker to form PROTACs(Proteolysis Targeting Chimera).	price>
R-R-3993	Buloxibutid CAS No.477775-14-7	Buloxibutid (AT2 receptor agonist C21)/CAS No.477775-14-7 is a agentlike selective angiotensin II AT2 receptor agonist with Ki values of 0.4 nM and >10 μM for the AT2 receptor and AT1 receptor, respectively.	price>
R-C-2294	NAcM-OPT CAS:2089293-61-6	NAcM-OPT is an orally bioavailable cullin neddylation 1(DCN1)inhibitor,which potently inhibits the DCN1-UBE2M interaction.	price>
R-R-3994	Irbesartan CAS No.138402-11-6	Irbesartan (SR-47436)/CAS No.138402-11-6 is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease.	price>
R-C-2295	NSC697923 CAS:343351-67-7	NSC697923 is a potent UBE2N(ubiquitin-conjugating enzyme E2 N,Ubc13) inhibitor. NSC697923 induces neuroblastoma(NB)cell death via promoting nuclear importation of p53 in p53 wild-type NB cells.NSC697923 also induces cell death in p53 mutant NB cells by activation of JNK-mediated apoptotic pathway.NSC697923 inhibits DNA damage and NF-κB signaling.Antitumor activity.	price>
R-R-3995	Olmesartan CAS No.144689-24-7	Olmesartan (RNH-6270)/CAS No.144689-24-7 is an angiotensin II receptor (AT1R) antagonist used to treat high blood pressure.	price>
R-C-2296	Levetiracetam (UCB-L059) CAS:102767-28-2	Levetiracetam, an antiepileptic agent,binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis.Levetiracetam modulates HDAC levels ultimately silencing MGMT,thus increasing Temozolomide effectiveness.A chemosensitizer agent.	price>
R-R-3996	Olodanrigan CAS No.1316755-16-4	Olodanrigan (EMA401)/CAS No.1316755-16-4 is a highly selective, orally active, peripherally restricted angiotensin II type 2 receptor (AT2R) antagonist. It is under development as a neuropathic pain therapeutic agent. Olodanrigan (EMA401) analgesic action appears to involve inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons.	price>
R-C-2297	Cilnidipine (FRC-8653) CAS:132203-70-4	Cilnidipine(FRC-8653)is a calcium channel blocker.Cilnidipine is the novel calcium antagonist accompanied with L-type and N-type calcium channel blocking function.It was approved in 1995.Compared with other calcium antagonists,cilnidipine can act on the N-type calcium channel that existing sympathetic nerve end besides acting on L-type calcium channel that similar to most of the calcium antagonists.	price>
R-R-3997	PD 123319 ditrifluoroacetate CAS No.136676-91-0	PD 123319 (ditrifluoroacetate)/CAS No.136676-91-0 is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.	price>
R-C-2298	MCU-i4 CAS:371924-24-2	MCU-i4 is a negative modulator of the mitochondrial calcium uniporter (MCU)complex that directly binds a specific cleft in MICU1 and decreases mitochondrial Ca2+ influx.	price>
R-R-3998	Azilsartan medoxomil CAS No.863031-21-4	Azilsartan medoxomil (TAK 491)/CAS No.863031-21-4 is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension.	price>
R-C-2299	Amlodipine maleate CAS:88150-47-4	Amlodipine maleate is a dihydropyridine calcium channel blocker,acts as an orally active antianginal agent.Amlodipine maleate blocks the voltage-dependent L-type calcium channels,thereby inhibiting the initial influx of calcium. Amlodipine maleate can be used for the research of high blood pressure and cancer.	price>
R-R-3999	Angiotensin II 5-valine CAS No.58-49-1	Angiotensin II 5-valine/CAS No.58-49-1 is an agonist of angiotensin receptor.	price>
R-C-2300	Loureirin B CAS:119425-90-0	Loureirin B(LB,LrB),a flavonoid extracted from Dracaena cochinchinensis,is an inhibitor of PAI-1 with IC50 of 26.10μM.Loureirin B downregulates p-ERK and p-JNK in TGF-β1-stimulated fibroblasts.Loureirin B promotes insulin secretion mainly through increasing Pdx-1,MafA,intracellular ATP level,inhibiting the KATP current,influx of Ca2+ to the intracellular.	price>
R-R-4000	Olmesartan medoxomil CAS No.144689-63-4	Olmesartan medoxomil/CAS No.144689-63-4 is a potent and selective angiotensin AT1 receptor inhibitor with IC50 of 66.2 μM.	price>
R-C-2301	Ranolazine CAS:95635-55-5	Ranolazine(CVT 303)is an anti-angina drug that achieves its effects by inhibiting the late phase of inward sodium current(INa and IKr with IC50 values of 6μM and 12μM, respectively)without affecting heart rate or blood pressure(BP).Ranolazine is also a partial fatty acid oxidation(FAO)inhibitor.Antianginal agent.	price>

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