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Catalog	name	Description	price
R-C-2218	BMS-1166 CAS:1818314-88-3	BMS-1166 is a potent PD-1/PD-L1 immune checkpoint inhibitor.BMS-1166 induces dimerization of PD-L1 and blocks its interaction with PD-1,with an IC50 of 1.4 nM.BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation.	price>
R-R-3918	Abanoquil CAS No.90402-40-7	Abanoquil (U-K52046)/CAS No.90402-40-7, an potent and selective α-1 adrenoceptor antagonist, is an anti-arrhythmic agent. Abanoquil can be used for erectile dysfunction research.	price>
R-C-2219	BMS-1001 CAS: 2113650-03-4	BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction with EC50 of 253nM.BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes.	price>
R-R-3919	Ivabradine-d6 hydrochloride CAS No.2070009-63-9	Ivabradine-d6 (hydrochloride)/CAS No.2070009-63-9 is the deuterium labeled Ivabradine hydrochloride. Ivabradine hydrochloride is a new If inhibitor with IC50 of 2.9 μM, and used as a pure heart rate lowering agent.	price>
R-C-2220	Durvalumab (anti-PD-L1) CAS:1428935-60-7	Durvalumab(MEDI 4736)is an humanized anti-PD-L1 monoclonal antibody.Durvalumab (MEDI4736)completely blocks the binding of PD-L1 to both PD-1 and CD80, with IC50s of 0.1 and 0.04nM,respectively.	price>
R-R-3920	N-(Phenylacetyl-d5)glycine CAS No.1189920-31-7	N-(Phenylacetyl-d5)glycine/CAS No.1189920-31-7 is the deuterium labeled Phenylacetylglycine. Phenylacetylglycine is a gut microbial metabolite that can activate β2AR. Phenylacetylglycine protects against cardiac injury caused by ischemia/reperfusion.	price>
R-C-2221	TCPOBOP CAS:76150-91-9	TCPOBOP is an agonist of the constitutive androstane receptor(CAR)(EC50=20nM). TCPOBOP enhances the nuclear receptor CAR transactivation of cytochrome P450 (CYP),as dose-dependent direct agonist of CAR.	price>
R-R-3921	Tetrahydroalstonine CAS No.6474-90-4	Tetrahydroalstonine/CAS No.6474-90-4, a indole alkaloid isolated from the fruits of Rhazya stricta, is a selective alpha 2-adrenoceptor antagonist.	price>
R-C-2222	Marinopyrrole A (Maritoclax) CAS:1227962-62-0	Marinopyrrole A(Maritoclax)is a selective Mcl-1 antagonist.It binds to Mcl-1,but not Bcl-XL,and targets Mcl-1 for proteasomal degradation.Maritoclax disrupts the interaction between Bim and Mcl-1 with an IC50 of 10.1μM.	price>
R-R-3922	Tulobuterol-d9 hydrochloride CAS No.1325559-14-5	Tulobuterol-d9 (hydrochloride)/CAS No.1325559-14-5 is the deuterium labeled Tulobuterol. Tulobuterol (C-78 free base) is a long-acting β2-adrenoceptor agonist, which reduces the frequency of exacerbations of chronic obstructive pulmonary disease and bronchial asthma. Tulobuterol is also a sympathomimetic agent used as a transdermal patch, and increases normal diaphragm muscle strength.	price>
R-C-2223	Obatoclax Mesylate (GX15-070) CAS: 803712-79-0	Obatoclax Mesylate(GX15-070 Mesylate),a BH3 mimetic,is a pan-BCL-2 family proteins inhibitor with a Ki of 220nM for BCL-2.Obatoclax Mesylate induces autophagy-dependent cell death and targets cyclin D1 for proteasomal degradation.Obatoclax Mesylate has anti-cancer and broad-spectrum antiparasitic activity.	price>
R-R-3923	Mapenterol hydrochloride CAS No.54238-51-6	Mapenterol hydrochloride/CAS No.54238-51-6 is a type of β2-adrenoceptor agonist.	price>
R-C-2224	Ethyl gallate CAS:831-61-8	Ethyl gallat(Phyllemblin,gallic acid ethyl ester),which could be found naturally in a variety of plant sources,is a food additive with antimicrobial activity. Ethyl gallat activates the death receptor-dependent pathway of apoptosis by enhancing the expression of caspases-8,-9,and -3 and the Bcl-2 interacting domain(Bid).	price>
R-R-3924	Romifidine CAS No.65896-16-4	Romifidine/CAS No.65896-16-4 is an α2 adrenergic receptor agonist. Romifidine shows sedation effects in vivo.	price>
R-C-2225	Resveratrol (SRT501) CAS: 501-36-0	Resveratrol(SRT501,trans-Resveratrol)has a wide spectrum of targets including cyclooxygenases(COX,IC50=1.1μM),lipooxygenases（LOX,IC50=2.7μM),kinases, sirtuins and other proteins.It has anti-cancer,anti-inflammatory,blood-sugar-lowering and other beneficial cardiovascular effects.Resveratrol induces mitophagy/autophagy and autophagy-dependent apoptosis.	price>
R-R-3925	Prenalterol CAS No.57526-81-5	Prenalterol/CAS No.57526-81-5 is a selective β1-adrenergic receptor agonist. Prenalterol has no effect on gut smooth muscle contractile activity. Prenalterol can be used for researching cardiovascular disease.	price>
R-C-2226	Perifosine (KRX-0401)	Perifosine is an orally active alkyl-phosphocholine compound with potential antineoplastic activity.Targeting cellular membranes,perifosine modulates membrane permeability,membrane lipid composition,phospholipid metabolism,and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth.This agent also inhibits the anti-apoptotic mitogen-activated protein kinase(MAPK)pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase(SAPK/JNK)pathways,thereby inducing apoptosis.	price>
R-R-3926	Oxprenolol-d7 hydrochloride CAS No.1189649-47-5	Oxprenolol-d7 (hydrochloride)/CAS No.1189649-47-5 is the deuterium labeled Oxprenolol hydrochloride. Oxprenolol hydrochloride (Ba 39089) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a Ki of 7.10 nM in a radioligand binding assay using rat heart muscle.	price>
R-C-2227	Rigosertib (ON-01910) CAS:592542-59-1	Rigosertib(ON-01910)is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9nM in a cell-free assay.It shows 30-fold greater selectivity against Plk2 and no activity to Plk3.Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals.Rigosertib induces apoptosis in various cancer cells.	price>
R-R-3927	AGN 192836 CAS No.171102-29-7	AGN 192836/CAS No.171102-29-7 is a potent and selective α2 adrenergic agonist with EC50s of 8.7, 41 and 6.6 nM for α2A, α2B and α2C receptor, respectively.	price>

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