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Catalog	name	Description	price
R-C-2208	2-D08 CAS:144707-18-6	2-D08 is a cell permeable,mechanistically unique inhibitor of protein sumoylation.It is also inhibits Axl,IRAK4,ROS1,MLK4,GSK3β,RET,KDR and PI3Kα with IC50 values of 0.49,3.9,5.3,9.8,11,11,17 and 35nM respectively in biochemical assays.	price>
R-R-3908	Bunazosin CAS No.80755-51-7	Bunazosin/CAS No.80755-51-7 is a potent and selective α1-adrenoceptor antagonist. Bunazosin can be used for antihypertensive and ocular hypotensive research.	price>
R-C-2209	CS-2660 (JNJ-38158471) CAS:951151-97-6	CS-2660(JNJ-38158471)is a well tolerated,orally available,highly selective VEGFR-2 inhibitor with IC50 of 40 nM.CS-2660(JNJ-38158471)also inhibits closely related tyrosine kinases such as RET(c-RET)and Kit(c-Kit)with IC50 of 180nM and 500nMwhile it has no significant activity(>1 microM) against VEGFR-1 and VEGFR-3.	price>
R-R-3909	Salbutamol-d3 CAS No.1219798-60-3	Salbutamol-d3/CAS No.1219798-60-3 is the deuterium labeled Salbutamol. Salbutamol is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and chronic obstructive pulmonary disease (COPD).	price>
R-C-2210	Ningetinib CAS:1394820-69-9	Ningetinib is a potent,orally bioavailable small molecule tyrosine kinase inhibitor(TKI)with IC50s of 6.7,1.9 and<1.0nM for c-Met,VEGFR2 and Axl,respectively.	price>
R-R-3910	Midaglizole CAS No.66529-17-7	Midaglizole ((±)-DG5128 free base, DG5128 free base)/CAS No.66529-17-7 is a potent α2-adrenoceptor antagonist. Midaglizole is a hypoglycemic agent. Midaglizole increases blood pressure and reduces blood glucose levels in vivo.	price>
R-C-2211	CZC-8004 CAS:916603-07-1	CZC-8004 is a pan-kinase inhibitor and binds a range of tyrosine kinases, including ABL kinase.	price>
R-R-3911	ICI 89406 CAS No.53671-71-9	ICI 89406/CAS No.53671-71-9 is a selective β1 adrenergic receptor antagonist amenable to labelling with positron emitters, for PET.	price>
R-C-2212	AG-13958 CAS:319460-94-1	AG-13958(AG-013958),a potent VEGFR tyrosine kinase inhibitor,is used for treatment of choroidal neovascularization associated with age-related macular degeneration(AMD).	price>
R-R-3912	Phenylephrine-2,4,6-d3 hydrochloride CAS No.1276197-50-2	Phenylephrine-2,4,6-d3 (hydrochloride)/CAS No.1276197-50-2 is the deuterium labeled Phenylephrine hydrochloride. (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.	price>
R-C-2213	Donafenib (Sorafenib D3) CAS:1130115-44-4	Sorafenib(D3)(Bay 43-9006 (D3))is the deuterium labeled Sorafenib.Sorafenib is a multikinase inhibitor IC50s of 6nM,20nM,and 22nM for Raf-1, B-Raf,and VEGFR-3, respectively.	price>
R-R-3913	Amosulalol CAS No.85320-68-9	Amosulalol (YM 09538)/CAS No.85320-68-9 is an orally active and dual inhibitor of α1/β1-Adrenergic Receptor. Amosulalol exhibits antihypertensive activity via α1-Adrenergic Receptor inhibition. Amosulalol decreases reflexogenic increases in heart rate and plasma renin activity (PRA) via β1-Adrenergic Receptor inhibition in spontaneously hypertensive rats (SHR).	price>
R-C-2214	SKLB 610 CAS:1125780-41-7	SKLB610 is a VEGFR inhibitor that potently suppresses human tumor angiogenesis. SKLB610 inhibited angiogenesis-related tyrosine kinase VEGFR2,fibroblast growth factor receptor 2(FGFR2)and platelet-derived growth factor receptor(PDGFR)at rate of 97%,65% and 55%,respectively,at concentration of 10μM in biochemical kinase assays.SKLB610 exhibited its antitumor activity as a multi-targeted inhibitor with more potent inhibition of VEGFR2 activity.	price>
R-R-3914	Yohimbine-13C,d3 CAS No.1261254-59-4	Yohimbine-13C,d3/CAS No.1261254-59-4 is the 13C- and deuterium labeled Yohimbine. Yohimbine is a potent and relatively nonselective alpha 2-adrenergic receptor (AR) antagonist, with IC50 of 0.6 μM.	price>
R-C-2215	MAZ51 CAS:163655-37-6	MAZ51 is a potent and selective inhibitor of vascular endothelial growth factor receptor(VEGFR)-3(Flt-4)tyrosine kinase.MAZ51 induces cell rounding and G2/M cell cycle arrest in glioma cells through phosphorylation of Akt/GSK3β and activation of RhoA.MAZ51 inhibits the proliferation and induces the apoptosis of a variety of non-VEGFR-3-expressing tumor cell lines.	price>
R-R-3915	Upidosin CAS No.152735-23-4	Upidosin (Rec 15/2739)/CAS No.152735-23-4 is an α-1 adrenoceptor (α-1 AR) antagonist. Upidosin shows moderate selectivity for the α-1A AR subtype. Upidosin shows uroselectivity in urethra and prostate with a Kb value of 2-3 nM higher than in ear artery and aorta with a Kb value of 20-100 nM. Upidosin inhibits [3H]prazosin binding to cloned human α-1A adrenergic receptor. Upidosin can be used for the research of urethral obstruction.	price>
R-C-2216	SU5204 CAS:186611-11-0	SU5204,a tyrosine kinase inhibitor,has IC50s of 4 and 51.5μM for FLK-1(VEGFR-2)and HER2,respectively.	price>
R-R-3916	4-Hydroxyatomoxetine-d3 CAS No.1217686-14-0	4-Hydroxyatomoxetine-d3/CAS No.1217686-14-0 is a deuterium labeled 4-Hydroxyatomoxetine. 4-Hydroxyatomoxetine is an active metabolite of Atomoxetine (Tomoxetine). 4-Hydroxyatomoxetine is metabolized by the enzyme cytochrome P450 2D6 (CYP2D6). Atomoxetine is a potent and selective noradrenal in re-uptake inhibitor.	price>
R-C-2217	AUNP-12 CAS:1353563-85-5	AUNP-12(NP-12)is a peptide antagonist of the PD-1 signaling pathway,displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions.	price>
R-R-3917	Bambuterol-d9 hydrochloride CAS No.1794810-59-5	Bambuterol-d9 (hydrochloride)/CAS No.1794810-59-5 is the deuterium labeled Bambuterol. Bambuterol ((±)-Bambuterol) hydrochloride is a long acting beta-adrenoceptor agonist (LABA) used in the treatment of asthma; it also is a prodrug of terbutaline.	price>

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