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Catalog	name	Description	price
R-R-3926	Oxprenolol-d7 hydrochloride CAS No.1189649-47-5	Oxprenolol-d7 (hydrochloride)/CAS No.1189649-47-5 is the deuterium labeled Oxprenolol hydrochloride. Oxprenolol hydrochloride (Ba 39089) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a Ki of 7.10 nM in a radioligand binding assay using rat heart muscle.	price>
R-C-2227	Rigosertib (ON-01910) CAS:592542-59-1	Rigosertib(ON-01910)is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9nM in a cell-free assay.It shows 30-fold greater selectivity against Plk2 and no activity to Plk3.Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals.Rigosertib induces apoptosis in various cancer cells.	price>
R-R-3927	AGN 192836 CAS No.171102-29-7	AGN 192836/CAS No.171102-29-7 is a potent and selective α2 adrenergic agonist with EC50s of 8.7, 41 and 6.6 nM for α2A, α2B and α2C receptor, respectively.	price>
R-C-2228	Lupenone CAS:1617-70-5	Lupenone,isolated from Rhizoma Musae,belongs to lupane type triterpenoids. Lupenone shows various pharmacological activities including anti-inflammatory, anti-virus,anti-diabetes,anti-cancer,improving Chagas disease without major toxicity.	price>
R-R-3928	Dopexamine hydrochloride CAS No.86484-91-5	Dopexamine hydrochloride/CAS No.86484-91-5 is a β2 adrenergic receptor agonist.	price>
R-C-2229	Solasodine CAS:126-17-0	Solasodine(Purapuridine,Solancarpidine,Solasodin,Salasodine,Salasdine)is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family.Solasodine reduces the mRNA level of matrix metalloproteinase-2(MMP-2), MMP-9 and extracellular inducer of matrix metalloproteinase(EMMPRIN),but increases the expression of reversion-inducing cysteine-rich protein with kazal motifs(RECK).Solasodine downregulates oncogenic microRNA-21(miR-21),which has been known to target RECK.Solasodine also reduces PI3K/Akt signaling pathways and downregulates expression of miR-21.	price>
R-R-3929	O-Desmethyl Mebeverine alcohol hydrochloride CAS No.856620-39-8	O-Desmethyl Mebeverine alcohol hydrochloride/CAS No.856620-39-8 is a metabolite of Mebeverine, which is a potent α1 repector inhibitor, causing relaxation of the gastrointestinal tract.	price>
R-C-2230	Hispidulin CAS:1447-88-7	Hispidulin(Dinatin),an active natrual ingredient in a number of traditional Chinese medicinal herbs,exhibits inhibitory activity against the oncogenic protein kinase Pim-1 with IC50 of 2.71μM.Hispidulin induces apoptosis through mitochondrial dysfunction and inhibition of P13k/Akt signalling pathway in HepG2 cancer cells.Hispidulin exerts anti-osteoporotic and bone resorption attenuating effects via activating the AMPK signaling pathway.	price>
R-R-3930	(Rac)-Timolol-d5 maleate CAS No.1217260-21-3	Rac Timolol-d5 (maleate)/CAS No.1217260-21-3 is a labelled racemic (S)-Timolol maleate. (S)-Timolol Maleate (L-714,465 Maleate) is a non-cardioselective hydrophilic β-adrenoceptor blocker. (S)-Timolol Maleate is widely used as standard medication for intraocular pressure (glaucoma) by preventing the production of aqueous humor. (S)-Timolol Maleate can be used for hypertension, angina pectoris and myocardial infarction.	price>
R-C-2231	Trigonelline CAS： 535-83-1	Trigonelline,an alkaloid with potential antidiabetic activity,is present in considerable amounts in coffee.Trigonelline is an efficient Nrf2 inhibitor capable of blocking Nrf2-dependent proteasome activity and thereby apoptosis protection in pancreatic cancer cells.	price>
R-R-3931	Fenoterol-d6 hydrobromide CAS No.1286129-04-1	Fenoterol-d6 (hydrobromide) (Th-1165a-d6)/CAS No.1286129-04-1 is the deuterium labeled Fenoterol hydrobromide. Fenoterol hydrobromide (Th-1165a), a sympathomimetic agent, is a selective and orally active β2-adrenoceptor agonist. Fenoterol hydrobromide is an effective bronchodilator and can be used for bronchospasm associated with asthma, bronchitis and other obstructive airway diseases research.	price>
R-C-2232	Loureirin A CAS：119425-89-7	Loureirin A is a flavonoid extracted from Dragon is Blood,can inhibit Akt phosphorylation,and has antiplatelet activity.	price>
R-R-3932	Bufuralol-d9 hydrochloride CAS No.1173023-51-2	Bufuralol-d9 (hydrochloride)/CAS No.1173023-51-2 is the deuterium labeled Bufuralol hydrochloride.	price>
R-C-2233	AT7867 CAS：857531-00-1	AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17nM/47nM and 85nM/20nM in cell-free assays,respectively;little activity outside the AGC kinase family.	price>
R-R-3933	Bisoprolol-d5 CAS No.1189881-87-5	Bisoprolol-d5/CAS No.1189881-87-5 is the deuterium labeled Bisoprolol. Bisoprolol is a potent, selective and orally active β1-adrenergic receptor blocker. Bisoprolol has little activity on β2-receptor and has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research.	price>
R-C-2234	Triciribine (NSC 154020) CAS:35943-35-2	Triciribine(VQD-002)is a potent AKT inhibitor and a cell-permeable tricyclic nucleoside molecule with potential antineoplastic activity.Triciribine inhibits the phosphorylation,activation, and signalling of Akt-1,-2,and-3,which may result in the inhibition of Akt-expressing tumor cell proliferation.Akts are anti-apoptotic serine/theronine-specific protein kinases that phosphorylate and inactivate components of the apoptotic machinery,including Bcl-xL/Bcl-2-associated death promoter(BAD)and caspase 9.	price>
R-R-3934	Atomoxetine-d3 hydrochloride CAS No.1217776-38-9	Atomoxetine-d3 hydrochloride/CAS No.1217776-38-9 is the deuterium labeled Atomoxetine hydrochloride. Atomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5, 77 and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively).	price>
R-C-2235	CCT128930 CAS： 885499-61-6	CCT128930 is a potent,ATP-competitive and selective inhibitor of Akt2 with IC50 of 6nM in a cell-free assay,28-fold greater selectivity for Akt2 than the closely related PKA kinase.CCT128930 induces cell cycle arrest,DNA damage,and autophagy independent of Akt inhibition.High dose of CCT128930 triggers cell apoptosis in HepG2 cells.	price>
R-R-3935	Doxazosin-d8 hydrochloride CAS No.1219803-95-8	Doxazosin-d8 (hydrochloride)/CAS No.1219803-95-8 is the deuterium labeled Doxazosin hydrochloride.	price>
R-C-2236	Miltefosine CAS：58066-85-6	Miltefosine(Hexadecylphosphocholine)inhibits PI3K/Akt activity with ED50 of 17.2μM and 8.1μM in carcinoma cell lines A431 and HeLa,first oral drug for Visceral leishmaniasis,effective against both promastigotes and amastigotes.	price>

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